Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0236167
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
The Sydney Combinatorial Research Facility. The proposal is to establish a multidisciplinary inter-institutional research facility for solution-phase combinatorial chemistry synthesis and analysis, and medium to high throughput biological evaluation of lead compounds through fluorescence detection methods. This will be the first and only multi-user facility of its type in Sydney. It will provide through its synthetic node at NSW and Macquarie Universities and biological screening node at Univers ....The Sydney Combinatorial Research Facility. The proposal is to establish a multidisciplinary inter-institutional research facility for solution-phase combinatorial chemistry synthesis and analysis, and medium to high throughput biological evaluation of lead compounds through fluorescence detection methods. This will be the first and only multi-user facility of its type in Sydney. It will provide through its synthetic node at NSW and Macquarie Universities and biological screening node at University of Sydney an essential resource that will enable modern combinatorial techniques to be applied to chemical and drug-lead development studies in the region.Read moreRead less
A New Synthesis of Steroid Conjugates for Illicit Drug Detection. The prevention of drug abuse in horse racing is vital to preserve the large contribution to employment, Government revenue and to economic activity provided by the Racing Industry. This collaboration aims to develop new highly sensitive analytical procedures for the detection of performance enhancing drugs in horses. The project will develop novel chemistry for the production of standard compounds that are essential for this testi ....A New Synthesis of Steroid Conjugates for Illicit Drug Detection. The prevention of drug abuse in horse racing is vital to preserve the large contribution to employment, Government revenue and to economic activity provided by the Racing Industry. This collaboration aims to develop new highly sensitive analytical procedures for the detection of performance enhancing drugs in horses. The project will develop novel chemistry for the production of standard compounds that are essential for this testing program and are currently unavailable by other means. The methods developed will have wider application to the testing of drugs in athletes and the detection of recreational drugs.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100677
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Deconstructing molecular self-assembly by advanced mass spectrometry. This project aims to develop ion-mobility mass spectrometry methods to observe the molecular evolution of model self-assembly reactions with high temporal and structural resolution, and interrogate the intrinsic gas phase functionality of the assemblies themselves, including aggregation, inclusion and disassembly behaviours. Lack of knowledge of reaction intermediates, mechanisms and kinetics hampers the industrial potential o ....Deconstructing molecular self-assembly by advanced mass spectrometry. This project aims to develop ion-mobility mass spectrometry methods to observe the molecular evolution of model self-assembly reactions with high temporal and structural resolution, and interrogate the intrinsic gas phase functionality of the assemblies themselves, including aggregation, inclusion and disassembly behaviours. Lack of knowledge of reaction intermediates, mechanisms and kinetics hampers the industrial potential of self-assembly to fabricate highly functional materials. This project expects to determine the critical link between the assemblies’ structure and function, and provide the rational framework to optimise and direct synthetic outcomes. This could enable Australian manufacturers to create low-energy production processes of high value commodities.Read moreRead less
Charting intercellular space. The space between the cells in our bodies is poorly understood. Chemical imbalances in this region are associated with many diseases, such as prostate cancer, Alzheimer's disease, sleep disorders and depression. This project combines synthetic chemistry and semiconductor technology to understand such imbalances, and their role in disease.
Strategies for the detection of designer steroids in greyhounds. Strategies for the detection of designer steroids in greyhounds. This project aims to develop strategies to detect designer steroids in racing greyhounds to safeguard industry integrity and animal welfare. These strategies include in vivo and comparative in vitro studies of steroid metabolism, mass-spectrometric elucidation of metabolite structures, and synthesis of putative steroid metabolites with different stereochemistries and ....Strategies for the detection of designer steroids in greyhounds. Strategies for the detection of designer steroids in greyhounds. This project aims to develop strategies to detect designer steroids in racing greyhounds to safeguard industry integrity and animal welfare. These strategies include in vivo and comparative in vitro studies of steroid metabolism, mass-spectrometric elucidation of metabolite structures, and synthesis of putative steroid metabolites with different stereochemistries and oxidation patterns as reference materials. This project will use major metabolites identified by these studies to develop analytical procedures to test for drug abuse at greyhound race meetings. The project will target twelve readily available designer steroid supplements that have significant risk of abuse.Read moreRead less
Synthesis and Analysis of Canine Anabolic Steroid Metabolites. The Australian racing industry is a major driver of economic activity. In NSW, racing is estimated to contribute $1,000 million to GDP, $151 million to Government revenue and provide 50,000 jobs. The future security and prosperity of the racing industry depends on maintaining the highest standards of integrity in the public eye, and this in turn depends on the enforcement of regulations relating to illicit substances. The outcome of ....Synthesis and Analysis of Canine Anabolic Steroid Metabolites. The Australian racing industry is a major driver of economic activity. In NSW, racing is estimated to contribute $1,000 million to GDP, $151 million to Government revenue and provide 50,000 jobs. The future security and prosperity of the racing industry depends on maintaining the highest standards of integrity in the public eye, and this in turn depends on the enforcement of regulations relating to illicit substances. The outcome of this project will be the introduction of robust methods of analysis for potential drug abuse in greyhound racing that will position Australia as a world leader in the field.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101863
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Strained alkenes as chemical probes for cysteine sulfenic acid. This project aims to introduce strained alkenes as probes for cysteine sulfenic acid, a poorly understood biomarker for oxidative stress. This probe will enable rapid detection of cysteine sulfenic acid and meet an urgent need for tools to map cysteine redox signalling. Moreover, since many enzymes feature a cysteine sulfenic acid at their active site, the strained alkene probes will also serve as useful inhibitor probes of these en ....Strained alkenes as chemical probes for cysteine sulfenic acid. This project aims to introduce strained alkenes as probes for cysteine sulfenic acid, a poorly understood biomarker for oxidative stress. This probe will enable rapid detection of cysteine sulfenic acid and meet an urgent need for tools to map cysteine redox signalling. Moreover, since many enzymes feature a cysteine sulfenic acid at their active site, the strained alkene probes will also serve as useful inhibitor probes of these enzymes. Such inhibitor probes will provide critical information for potential therapeutic applications in human conditions associated with oxidative stress such as ageing, cancer, and heart disease.Read moreRead less
Connecting soil nitrogen and plant uptake for greener agriculture. This project will use synthetic organic chemistry, biochemistry, root and rhizosphere biology and rhizosphere modelling to establish detailed mechanistic knowledge of the nitrogen (N) transport and uptake processes at the soil-root interface to develop new, efficient urease and nitrification inhibitors for reliable provision of N to the plant/root system. The reduction of excessive N fertilisation has significant environmental be ....Connecting soil nitrogen and plant uptake for greener agriculture. This project will use synthetic organic chemistry, biochemistry, root and rhizosphere biology and rhizosphere modelling to establish detailed mechanistic knowledge of the nitrogen (N) transport and uptake processes at the soil-root interface to develop new, efficient urease and nitrification inhibitors for reliable provision of N to the plant/root system. The reduction of excessive N fertilisation has significant environmental benefits by reducing greenhouse gas emissions and water pollution. This project will lead to a breakthrough for the triple challenge of food security, environmental degradation and climate change, while improving plant productivity and increasing the profitability of agriculture through lower fertiliser costs.Read moreRead less
New photoinitiators and polymers for tack-free LED cured surface coatings. This project aims to develop surface coatings curable by energy from Light Emitting Diodes (LEDS) by overcoming existing hurdles, while improving workplace health and safety.
The project expects to achieve this by developing a new class of photoinitiator molecules, with enhanced reactivity, via a unique understanding of synthesis, photochemistry and commercial coatings formulation.
Outcomes will be new surface coatings ....New photoinitiators and polymers for tack-free LED cured surface coatings. This project aims to develop surface coatings curable by energy from Light Emitting Diodes (LEDS) by overcoming existing hurdles, while improving workplace health and safety.
The project expects to achieve this by developing a new class of photoinitiator molecules, with enhanced reactivity, via a unique understanding of synthesis, photochemistry and commercial coatings formulation.
Outcomes will be new surface coatings for a wide range of end uses, publication in high ranking journals and commercialisation of the technology.
Benefits of this project will include elimination of mercury and reduction in exposure to solvents in the Australian workplace, and a lower energy requirement to produce high-quality surface coated products.Read moreRead less