Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346903
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
LC-MS system for Faculty of Sciences, U.N.E. LC-MS is a technique for investigating the composition of complex mixtures and identifying its components. This instrumentation will be utilised at UNE in a diverse range of analytical investigations to further the research aims of scientists in chemistry, biological sciences, archaeology, physics, environmental sciences, marine science as well as biological researchers in specialised units based at UNE. The extraordinarily versatile capacity of this ....LC-MS system for Faculty of Sciences, U.N.E. LC-MS is a technique for investigating the composition of complex mixtures and identifying its components. This instrumentation will be utilised at UNE in a diverse range of analytical investigations to further the research aims of scientists in chemistry, biological sciences, archaeology, physics, environmental sciences, marine science as well as biological researchers in specialised units based at UNE. The extraordinarily versatile capacity of this technique for analysis and identification of organic substances, from small molecules through to large proteins and complex plant and animal metabolites, will provide impetus for existing research and stimulus for new research directions.Read moreRead less
Differential Isotope Proteome Mapping of Transforming Growth Factor Beta Cell Signalling. Our research will capitalise on Australia's expertise and prior infrastructure investments in frontier, proteomic technologies to elucidate novel intracellular signalling pathways that contribute to the development of cancer. New approaches will be developed using isotopes to provide sensitive and accurate measurements of changes in protein expression levels. This technology will allow us to define complex ....Differential Isotope Proteome Mapping of Transforming Growth Factor Beta Cell Signalling. Our research will capitalise on Australia's expertise and prior infrastructure investments in frontier, proteomic technologies to elucidate novel intracellular signalling pathways that contribute to the development of cancer. New approaches will be developed using isotopes to provide sensitive and accurate measurements of changes in protein expression levels. This technology will allow us to define complex intracellular signalling networks. This is an important step towards identifying new drug targets that are responsible for tumour growth. Australian science will benefit from the training of new scientists in modern, post-genome technologies where there is currently a world shortage of experienced personnel.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
Why is ColorbondR steel greener on the other side of the fence? Designing additives to retard weathering of surface coatings. COLORBONDR steel, the flagship pre-painted steel product of BlueScope Steel Limited, has become an iconic part of both suburban and outback landscapes whether installed as roofing, walling or water conservation accessories (tanks, down-pipes etc). This proposal aims to provide a detailed understanding of molecular level changes in COLORBONDR steel surface coatings brought ....Why is ColorbondR steel greener on the other side of the fence? Designing additives to retard weathering of surface coatings. COLORBONDR steel, the flagship pre-painted steel product of BlueScope Steel Limited, has become an iconic part of both suburban and outback landscapes whether installed as roofing, walling or water conservation accessories (tanks, down-pipes etc). This proposal aims to provide a detailed understanding of molecular level changes in COLORBONDR steel surface coatings brought about by levels of heat and radiation encountered in-service. These insights will lead to further improvements in both lifetime and aesthetic durability of COLORBONDR steel, ensuring continuing economic success of BlueScope in the domestic building market with consequent benefits to manufacturing communities throughout the supply-chain nationwide.Read moreRead less
Development of stable, patterned Self-Assembled Monolayers on carbon for sensors and other nanotechnology applications. Nanotechnology - science at the scale of a billionth of a metre - rests on our ability to manipulate molecules and to build structures that will be part of useful devices. We shall develop new methods to put that chemistry on carbon surfaces - leading to very stable and cheap devices that will have 'real world' applications in environmental monitoring. A 'bottom up' method of f ....Development of stable, patterned Self-Assembled Monolayers on carbon for sensors and other nanotechnology applications. Nanotechnology - science at the scale of a billionth of a metre - rests on our ability to manipulate molecules and to build structures that will be part of useful devices. We shall develop new methods to put that chemistry on carbon surfaces - leading to very stable and cheap devices that will have 'real world' applications in environmental monitoring. A 'bottom up' method of fabrication exploits the ability of similar molecules to line up on a suitable surface, so-called 'self Assembly'. The project is based on sound fundamental science for an applied research outcome and therefore will enhance Australian's standing as a strong scientific country that applies its knowledge at the forefront of technological advancement.Read moreRead less
Pulsed oscillating mass analyser. Mass spectrometers are ubiquitous components in chemical analysis, but are often large and expensive. We have developed a new method for mass analysis, which is smaller and cheaper than existing technology. However, the analyser needs further research to determine whether it has the performance specifications to match the other technologies. The objective of this research is to characterise, explore and extend the prototype and to develop the appropriate math ....Pulsed oscillating mass analyser. Mass spectrometers are ubiquitous components in chemical analysis, but are often large and expensive. We have developed a new method for mass analysis, which is smaller and cheaper than existing technology. However, the analyser needs further research to determine whether it has the performance specifications to match the other technologies. The objective of this research is to characterise, explore and extend the prototype and to develop the appropriate mathematical algorithm for mass analysis. Success in this project may lead to a new mass analyser that can be incorporated into analytical instruments, many of which are manufactured in Australia.Read moreRead less
Synthesis and Analysis of Canine Anabolic Steroid Metabolites. The Australian racing industry is a major driver of economic activity. In NSW, racing is estimated to contribute $1,000 million to GDP, $151 million to Government revenue and provide 50,000 jobs. The future security and prosperity of the racing industry depends on maintaining the highest standards of integrity in the public eye, and this in turn depends on the enforcement of regulations relating to illicit substances. The outcome of ....Synthesis and Analysis of Canine Anabolic Steroid Metabolites. The Australian racing industry is a major driver of economic activity. In NSW, racing is estimated to contribute $1,000 million to GDP, $151 million to Government revenue and provide 50,000 jobs. The future security and prosperity of the racing industry depends on maintaining the highest standards of integrity in the public eye, and this in turn depends on the enforcement of regulations relating to illicit substances. The outcome of this project will be the introduction of robust methods of analysis for potential drug abuse in greyhound racing that will position Australia as a world leader in the field.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989491
Funder
Australian Research Council
Funding Amount
$172,025.00
Summary
Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemi ....Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemistry and hydrometallurgy, aquaculture, forensic analysis, Antarctic studies, and environmental monitoring. This will directly support our work falling under National Research Priorities 1 An Environmentally Sustainable Australia, 2 Promoting and Maintaining Good Health, 3 Frontier Technologies for Building and Transforming Australian Industries, and 4 Safeguarding Australia.Read moreRead less
The fate of dietary selenium in vivo; a direct approach to linking chemical form with biological activity. Dietary selenium supplementation has great potential as a preventative treatment for a range of human health conditions, including cancer, that widely affect the Australian population. However, the adverse effects of such treatments are not fully recognised. This project will increase our knowledge of how selenium compounds are stored and utilised in the body and relate the information to c ....The fate of dietary selenium in vivo; a direct approach to linking chemical form with biological activity. Dietary selenium supplementation has great potential as a preventative treatment for a range of human health conditions, including cancer, that widely affect the Australian population. However, the adverse effects of such treatments are not fully recognised. This project will increase our knowledge of how selenium compounds are stored and utilised in the body and relate the information to clinical observations regarding dietary intake of selenium and other compounds. The new understanding generated will delineate the conditions for safe intake, so that the beneficial effects associated with selenium supplementation may be harnessed more effectively.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0236167
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
The Sydney Combinatorial Research Facility. The proposal is to establish a multidisciplinary inter-institutional research facility for solution-phase combinatorial chemistry synthesis and analysis, and medium to high throughput biological evaluation of lead compounds through fluorescence detection methods. This will be the first and only multi-user facility of its type in Sydney. It will provide through its synthetic node at NSW and Macquarie Universities and biological screening node at Univers ....The Sydney Combinatorial Research Facility. The proposal is to establish a multidisciplinary inter-institutional research facility for solution-phase combinatorial chemistry synthesis and analysis, and medium to high throughput biological evaluation of lead compounds through fluorescence detection methods. This will be the first and only multi-user facility of its type in Sydney. It will provide through its synthetic node at NSW and Macquarie Universities and biological screening node at University of Sydney an essential resource that will enable modern combinatorial techniques to be applied to chemical and drug-lead development studies in the region.Read moreRead less