Developing next-generation mass spectrometry imaging with isomer resolution. Mass spectrometry imaging (MSI) is a rapidly emerging technology for mapping molecular distributions within biological samples. This project will bring together market-leading MSI instrumentation from the industry partner Waters Corporation with unique technologies developed at QUT and UOW to develop an integrated MSI-platform capable of achieving high mass- and spatial-resolution, as well as discrimination of lipid iso ....Developing next-generation mass spectrometry imaging with isomer resolution. Mass spectrometry imaging (MSI) is a rapidly emerging technology for mapping molecular distributions within biological samples. This project will bring together market-leading MSI instrumentation from the industry partner Waters Corporation with unique technologies developed at QUT and UOW to develop an integrated MSI-platform capable of achieving high mass- and spatial-resolution, as well as discrimination of lipid isomers. Resolution of lipid isomers using this instrumentation will afford researchers a first glimpse of isomer-resolved images that will be used to visualise tissue-specific changes resulting from underlying chemical, physical or metabolic processes; changes that are currently invisible to contemporary imaging technologies.Read moreRead less
Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is signi ....Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is significant because the unique combination of skills including synthetic chemistry, mass spectrometry, lipidomics, biochemistry, biophysics which aim to result in a major shift in the understanding of this layer.Read moreRead less
Darwin Harbour corals as environmental data archives and bio-monitors. The forecast rapid population growth and industrial development of the Darwin Harbour catchment necessitates research into novel environmental monitoring techniques to aid the sustainable management of the Harbours resources. This project will develop a powerful and cost-effective bio-monitoring system by using chemical data stored in yearly growth bands of coral skeletons stretching back at least two centuries. Such data wil ....Darwin Harbour corals as environmental data archives and bio-monitors. The forecast rapid population growth and industrial development of the Darwin Harbour catchment necessitates research into novel environmental monitoring techniques to aid the sustainable management of the Harbours resources. This project will develop a powerful and cost-effective bio-monitoring system by using chemical data stored in yearly growth bands of coral skeletons stretching back at least two centuries. Such data will form a comparative baseline against which present and future coral data on pollutants released by urban, industrial and other developments can be assessed.Read moreRead less
In-field assessment and lifetime prediction of composite insulators in high voltage electricity transmission networks. New types of composite insulators are now used in extra-high voltage overhead lines in Australia's national electricity grid. Flashover of such insulators due to early ageing may lead to unavailability of vital lines causing power transmission disruptions costing the National Electricity Market tens of millions of dollars.
In this project research will be conducted into agei ....In-field assessment and lifetime prediction of composite insulators in high voltage electricity transmission networks. New types of composite insulators are now used in extra-high voltage overhead lines in Australia's national electricity grid. Flashover of such insulators due to early ageing may lead to unavailability of vital lines causing power transmission disruptions costing the National Electricity Market tens of millions of dollars.
In this project research will be conducted into ageing of elastomers to provide early warning of insulator end-of-life and into new techniques for extracting elastomer samples from live high voltage insulators. Transgrid will cooperate in the application of the technology to give improved understanding of insulator ageing in transmission networks.
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Using multiple data sources to understand the opioid crisis in Australia . This project aims to improve the quality and integration of population-level data for monitoring the consumption of opioids, licit and illicit, in Queensland communities. The analysis of opioids in wastewater, integrated with opioid use information such as prescription and seizure statistics will vastly increase knowledge of consumption patterns of opioids. By analysing wastewater samples from 2011 and triangulating with ....Using multiple data sources to understand the opioid crisis in Australia . This project aims to improve the quality and integration of population-level data for monitoring the consumption of opioids, licit and illicit, in Queensland communities. The analysis of opioids in wastewater, integrated with opioid use information such as prescription and seizure statistics will vastly increase knowledge of consumption patterns of opioids. By analysing wastewater samples from 2011 and triangulating with other datasets, the expected outcomes include building capacity to estimate consumption of all opioids; detecting the misuse of licit and illicit opioids over time. Anticipated benefit is to provide objective evidence of opioid use patterns for decision makers and a framework for a national opioids monitoring program.Read moreRead less
Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Bet ....Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Better elemental and isotope ratio data from these high-throughput instruments will open up new real-world applications in many areas of Australian interest, such as biosecurity, forensics, groundwater management, and drug design. The research will also inform design of the next generation instruments by the industry partner.Read moreRead less
Development of a Novel Photoelectrochemical Method for Ultra-sensitive and Selective Determination of Organic Pollutants. Rapidly deteriorating environmental conditions have caused worldwide fresh water shortage problems. For Australia, this is an urgent issue due to our limited fresh water resources. Globally, all levels of governments and legislative authorities have attempted to adopt stricter environmental legislation and better water resource management practice to address these urgent prob ....Development of a Novel Photoelectrochemical Method for Ultra-sensitive and Selective Determination of Organic Pollutants. Rapidly deteriorating environmental conditions have caused worldwide fresh water shortage problems. For Australia, this is an urgent issue due to our limited fresh water resources. Globally, all levels of governments and legislative authorities have attempted to adopt stricter environmental legislation and better water resource management practice to address these urgent problems. However, these priorities cannot be achieved until large scale and accurate environmental data are available. The success of the project would result in a new environmental monitoring system capable of online, real-time monitoring of environmental water quality, which will directly benefit water resource management practice in Australia. Read moreRead less
Nutritional properties of mango fruits: linking plant genomics to cellular bioactivities. Mango fruits are prized for their sensorial properties, but little information is available on potential nutritional benefits. By using a broad-based bioactivity screen, followed up with specific bio-activity assays, molecular components within mango fruits that have the potential to deliver nutritional health benefits will be identified. This information will be used both to provide information on the prop ....Nutritional properties of mango fruits: linking plant genomics to cellular bioactivities. Mango fruits are prized for their sensorial properties, but little information is available on potential nutritional benefits. By using a broad-based bioactivity screen, followed up with specific bio-activity assays, molecular components within mango fruits that have the potential to deliver nutritional health benefits will be identified. This information will be used both to provide information on the properties of current mango varieties and to develop breeding tools for enhancing nutritional properties in future varieties.Read moreRead less
Novel antimicrobial target discovery by an integrated approach. The project aims to uncover the molecular targets of BDM-I, a novel antimicrobial candidate discovered by the start-up Australian company BioDiem Ltd. BDM-I is active against many drug resistant bacterial and fungal microorganisms and it is currently in pre-clinical development. However, the lack of resistant phenotypes makes it difficult to identify BDM-I’s mechanism of action. The project plans to use an integrated approach that c ....Novel antimicrobial target discovery by an integrated approach. The project aims to uncover the molecular targets of BDM-I, a novel antimicrobial candidate discovered by the start-up Australian company BioDiem Ltd. BDM-I is active against many drug resistant bacterial and fungal microorganisms and it is currently in pre-clinical development. However, the lack of resistant phenotypes makes it difficult to identify BDM-I’s mechanism of action. The project plans to use an integrated approach that combines a novel technique of in silico screening with experimental validation. Project outcomes are anticipated to include the first computational method to integrate target and ligand similarity for proteome-scale target and off-target discovery, which will advance the global fight against drug-resistant microorganisms.Read moreRead less
Identification of novel biomarkers in tears for prostate cancer diagnosis and prognosis. The purpose of this study is to identify novel biomarkers in the tears of patients with CaP. The use of the several techniques will increase the chance of success and enable us to find more diagnostic markers. If successful, the identified proteins may be used to diagnose and determine the stage of cancer. This will help guide clinicians in choosing the best treatment methods for an individual patient. The m ....Identification of novel biomarkers in tears for prostate cancer diagnosis and prognosis. The purpose of this study is to identify novel biomarkers in the tears of patients with CaP. The use of the several techniques will increase the chance of success and enable us to find more diagnostic markers. If successful, the identified proteins may be used to diagnose and determine the stage of cancer. This will help guide clinicians in choosing the best treatment methods for an individual patient. The markers may also be used to monitor the disease progress and the effects of treatment. The results from this study may improve the prognosis of CaP patients.Read moreRead less