Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a vi ....Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a visually cluttered world, from insects to humans or autonomous vehicles.Read moreRead less
Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to matu ....Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to mature cow oocytes in vitro by altering the chemical composition of maturation medium, thus improving the efficiency of laboratory embryo production and related technologies.Read moreRead less
Unravelling the principles of bilateral brain wiring. This project seeks to investigate the molecular principles of brain wiring in mammals and how small changes can generate complex outcomes. Neurons in the mammalian brain must be precisely wired together for the brain to function correctly. The project aims to identify the molecular and cellular rules governing commissural wiring in the mammalian cortex to determine how the largest fibre tract in the human brain, the corpus callosum, evolved. ....Unravelling the principles of bilateral brain wiring. This project seeks to investigate the molecular principles of brain wiring in mammals and how small changes can generate complex outcomes. Neurons in the mammalian brain must be precisely wired together for the brain to function correctly. The project aims to identify the molecular and cellular rules governing commissural wiring in the mammalian cortex to determine how the largest fibre tract in the human brain, the corpus callosum, evolved. This may have involved modifications in mechanisms affecting axon guidance that differ between placentals and marsupials. The project investigates the regulatory gene networks determining commissural neuron fate, the regulation of axon guidance components, and the influence of surrounding brain tissue on the development of commissural connections.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101394
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Early developmental influences on neocortical organisation. This project seeks to identify the influence of preceding developmental stages on the correct formation of the brain. Development is a sequence of transformations where every stage depends on the outcome of previous stages. The project intends to examine how the early sensory periphery, early-born brain circuits, and intrinsic neuronal interactions affect the subsequent organisation of the cerebral cortex – a mammal-specific brain regio ....Early developmental influences on neocortical organisation. This project seeks to identify the influence of preceding developmental stages on the correct formation of the brain. Development is a sequence of transformations where every stage depends on the outcome of previous stages. The project intends to examine how the early sensory periphery, early-born brain circuits, and intrinsic neuronal interactions affect the subsequent organisation of the cerebral cortex – a mammal-specific brain region responsible for perception, motor planning and cognition. It expects to provide novel mechanistic and conceptual insights into the process of normal brain development and more general biological phenomena, such as development and evolution. It may also provide insights into several genetic and non-genetic causes of brain malformations.Read moreRead less
A randomised controlled trial assessing the effects of a school-based sleep intervention in Year 6 and 7 students. Inadequate sleep is associated with a wide range of health problems in children, including obesity and poor performance at school. Children are sleeping less than ever before, and there is an increasing pattern of “yo yo sleeping” (sleep deprivation on school days followed by catch up sleeps on weekends). This study will trial a school-based program designed to improve the sleeping ....A randomised controlled trial assessing the effects of a school-based sleep intervention in Year 6 and 7 students. Inadequate sleep is associated with a wide range of health problems in children, including obesity and poor performance at school. Children are sleeping less than ever before, and there is an increasing pattern of “yo yo sleeping” (sleep deprivation on school days followed by catch up sleeps on weekends). This study will trial a school-based program designed to improve the sleeping habits of children. Better sleep is expected to result in improved alertness, better life satisfaction, and improved weight status.Read moreRead less
Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the ....Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the techniques of cognitive neuroscience, the project aims to provide a better understanding of the cognitive and neural mechanisms that govern attention in an applied setting. It expects to identify the factors that exacerbate lapses in attention and collisions. The effect of everyday impediments such as mobile phones, alcohol and fatigue will be investigated together with means of minimising these attentional lapses and improving safety.Read moreRead less
Understanding, measuring and managing the benefits of urban waterways. This project aims to improve understanding of the contribution of urban waterways to enhanced liveability in cities. Australia needs better water resource management and the rapid growth of Australia’s cities places increased importance on managing natural assets in metropolitan areas. The project focuses on clarifying the link between the benefits of waterways and the measurement techniques used by economists, which in turn ....Understanding, measuring and managing the benefits of urban waterways. This project aims to improve understanding of the contribution of urban waterways to enhanced liveability in cities. Australia needs better water resource management and the rapid growth of Australia’s cities places increased importance on managing natural assets in metropolitan areas. The project focuses on clarifying the link between the benefits of waterways and the measurement techniques used by economists, which in turn inform management choices. The project aims to fill an important gap between the psychology and economics disciplines and outputs should significantly improve the way waterways are valued and managed. This is intended to offer benefits for urban residents and to improve the methodologies used for environmental valuation.Read moreRead less
Development and implementation of biodiversity information for sustainable management of South Australian groundwater. Clean potable water is one of the most important resources for human health and a successful economy. Increasingly, subterranean aquifers are used for storage and recovery of water. These aquifers contain dynamic ecosystems, but little is known about species composition or about the importance of the presence of various species for water quality. We will use the latest laborator ....Development and implementation of biodiversity information for sustainable management of South Australian groundwater. Clean potable water is one of the most important resources for human health and a successful economy. Increasingly, subterranean aquifers are used for storage and recovery of water. These aquifers contain dynamic ecosystems, but little is known about species composition or about the importance of the presence of various species for water quality. We will use the latest laboratory techniques and DNA identification methods to provide a template for determining ground water diversity and food web dynamics throughout Australia. This project will lead to a better understanding of how to manage ground water in a sustainable manner.Read moreRead less
Strengthening community partnerships to promote adolescent school engagement and prevent problems such as alcohol misuse and violence. The project will reduce community rates of adolescent school non-attendance, adolescent alcohol misuse and antisocial behaviour. Adolescent school exclusion, alcohol use and antisocial behaviour are highly prevalent in Australia, and can be reduced using a variety of strategies that are coordinated at the school and community level. The project will decrease adol ....Strengthening community partnerships to promote adolescent school engagement and prevent problems such as alcohol misuse and violence. The project will reduce community rates of adolescent school non-attendance, adolescent alcohol misuse and antisocial behaviour. Adolescent school exclusion, alcohol use and antisocial behaviour are highly prevalent in Australia, and can be reduced using a variety of strategies that are coordinated at the school and community level. The project will decrease adolescent problems through community improvements in child and adolescent protective influences and reductions in risk influences. Furthermore, the project will equip communities with the capacity to learn how to identify and implement strategies to address the major influences that have the potential to reduce adolescent behaviour problems.Read moreRead less
Sleeping with one ear open: the impact on sleep and waking function. The aim of the project is to assess the impact 'on-call' work has on sleep, stress, and next day performance. Two million Australians are on-call providing essential 24-hour services including emergency response. While sleep during on-call periods is disrupted when a call occurs, some research suggests that sleeping with one ear open waiting for a call may disrupt sleep even if no call occurs. If on-call sleep is less restorati ....Sleeping with one ear open: the impact on sleep and waking function. The aim of the project is to assess the impact 'on-call' work has on sleep, stress, and next day performance. Two million Australians are on-call providing essential 24-hour services including emergency response. While sleep during on-call periods is disrupted when a call occurs, some research suggests that sleeping with one ear open waiting for a call may disrupt sleep even if no call occurs. If on-call sleep is less restorative, then individuals are at risk of performance impairment and adverse health outcomes. This project aims to answer questions about the magnitude of sleep disruption when on-call, the mechanisms for any disruption, and impact on waking function.Read moreRead less