Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new know ....Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new knowledge that will challenge current concepts of mammalian growth control. The outcomes will enhance Australia's international reputation in the fields of physiology, immunology and developmental biology. Read moreRead less
Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will ena ....Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will enable science-based guidelines, advancing disease control, local eradication, and regulatory approval for wombats. Our research framework is adaptable to other mange-impacted species, and advance methods and theory for control of treatable disease in wildlife.Read moreRead less
The role of neurohormones in the regulation of appetite and successful sea water transfer in farmed Atlantic salmon. Cultured Atlantic salmon spend the first part of their life in freshwater and then following a physiological adaption phase called smoltification, the fish (now termed smolts) are transferred to sea cages for growout. A proportion of smolts fail to thrive after transfer, show slow or no growth and usually die some months later. This project will investigate the role that the neuro ....The role of neurohormones in the regulation of appetite and successful sea water transfer in farmed Atlantic salmon. Cultured Atlantic salmon spend the first part of their life in freshwater and then following a physiological adaption phase called smoltification, the fish (now termed smolts) are transferred to sea cages for growout. A proportion of smolts fail to thrive after transfer, show slow or no growth and usually die some months later. This project will investigate the role that the neurohomones that control both appetite and physiological stress in fish have in stimulating the resumption of feeding after sea water transfer.The basic knowledge generated will be used directly in development of strategies for minimising smolt failure in Atlantic salmon aquaculture.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100016
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Predictive Breeding for Agricultural Futures. This Centre aims to develop the advanced capacity needed to secure Australia’s food and fibre production and export value into the future. Leveraging immense industry support, the Centre expects to develop and integrate cutting-edge plant and animal breeding technologies and deliver world-class training that addresses critical demand for highly skilled industry leaders. Expected outcomes include a future-ready predictive breedi ....ARC Training Centre in Predictive Breeding for Agricultural Futures. This Centre aims to develop the advanced capacity needed to secure Australia’s food and fibre production and export value into the future. Leveraging immense industry support, the Centre expects to develop and integrate cutting-edge plant and animal breeding technologies and deliver world-class training that addresses critical demand for highly skilled industry leaders. Expected outcomes include a future-ready predictive breeding industry able to transform data into optimised decisions, and the human capacity to drive it. This should provide significant benefits to enhance the sustainability and profitability of all major Australian agriculture sectors, including livestock, grains, horticulture, cotton, wine, dairy, forestry and fisheries.Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100014
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Sustainable Onshore Lobster Aquaculture. The project aims to build knowledge to establish the world’s first sustainable onshore lobster aquaculture industry focused on commercial, sustainable and socially responsible lobster production from hatchery to market. The project will investigate novel systems engineering, specialised feed manufacture, determination and modification of seedstock quality, new frontiers in seedstock transport, all within an informed environmental and ....ARC Research Hub for Sustainable Onshore Lobster Aquaculture. The project aims to build knowledge to establish the world’s first sustainable onshore lobster aquaculture industry focused on commercial, sustainable and socially responsible lobster production from hatchery to market. The project will investigate novel systems engineering, specialised feed manufacture, determination and modification of seedstock quality, new frontiers in seedstock transport, all within an informed environmental and marketing framework. The project will provide alternate solutions for lobster culture in bio-secure and cost effective onshore systems. The outcomes are targeted at positioning Australia at the forefront of onshore lobster aquaculture, with opportunity for technology transfer to other aquaculture sectors.Read moreRead less
Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidi ....Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidity by developing a multi-country study; and estimate the burden of diseases attributed to bushfire air pollution. This project will provide essential scientific evidence to policy-makers and stakeholders in the development, prioritization and implementation of health protection strategies and policies.
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Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-suppo ....Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-support and communication tool to inform the co-design of local climate change mitigation, adaptation and resilience plans. The project aims to give agency to Aboriginal communities in leading a systems change process to reduce environmental risks and strengthen health and wellbeing.Read moreRead less
Development of an immunology toolbox to combat emerging marsupial diseases. Disease is increasingly a driver of wildlife population declines in Australia. However, basic immunology tools for >99% of vertebrate species are scarce, limiting our ability to prevent and respond to emerging and endemic diseases, such as devil facial tumour disease and wobbly possum disease. The overarching goal of this project is to improve wildlife health and fill the marsupial immunology gap by developing a long-ove ....Development of an immunology toolbox to combat emerging marsupial diseases. Disease is increasingly a driver of wildlife population declines in Australia. However, basic immunology tools for >99% of vertebrate species are scarce, limiting our ability to prevent and respond to emerging and endemic diseases, such as devil facial tumour disease and wobbly possum disease. The overarching goal of this project is to improve wildlife health and fill the marsupial immunology gap by developing a long-overdue multispecies marsupial immunology toolbox. The toolbox is needed to accelerate devil facial tumour disease vaccine progress and conservation immunology research. It will expand our knowledge of wobbly possum disease virus that is increasingly reported in Tasmania and the risk posed by the virus to other possum species.Read moreRead less
Navigating an uncertain antimicrobial future: a sociological study. This project aims to develop a unique understanding of what governs antibiotic use in the health sector and how it can be governed more effectively. The project will critically assess the implementation of governance, and how regulatory and legislative environments may resonate or contrast with the demands of practice. This will support the development of strategies to improve antibiotic use and reduce resistance.