Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the struct ....Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the structural basis for their activity. We will do this by chemically synthesising peptides with selected residues mutated to determine their effects on activity.Read moreRead less
How triadin and junctin communicate with ryanodine receptors deep within a calcium store to determine skeletal muscle contraction. The project results will provide a platform for muscle relaxants and other drugs that will specifically target either the heart or skeletal muscle and will have applications in the livestock, veterinary and pharmaceutical Industries. The project falls within the National Research Priorities of Promoting and Maintaining Good Health and Frontier Technologies for Buil ....How triadin and junctin communicate with ryanodine receptors deep within a calcium store to determine skeletal muscle contraction. The project results will provide a platform for muscle relaxants and other drugs that will specifically target either the heart or skeletal muscle and will have applications in the livestock, veterinary and pharmaceutical Industries. The project falls within the National Research Priorities of Promoting and Maintaining Good Health and Frontier Technologies for Building and Transforming Australian Industries, as well as the national priority goal of Ageing well, Ageing Productively. The project will be of national benefit in training undergraduate students, PhD students and a postdoctoral fellow in state-of-the-art techniques in an internationally competitive research field.Read moreRead less
Synthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels. The aim of the project is develop synthetic compounds that specifically and reversibly activate or inhibit ryanodine receptor calcium release channels, and will thus increase or reduce the force developed by skeletal muscle and the heart. The compounds will be useful in biomedical and veterinary sciences and in the livestock industry. Some of the compounds that are not effective on mammalian ryan ....Synthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels. The aim of the project is develop synthetic compounds that specifically and reversibly activate or inhibit ryanodine receptor calcium release channels, and will thus increase or reduce the force developed by skeletal muscle and the heart. The compounds will be useful in biomedical and veterinary sciences and in the livestock industry. Some of the compounds that are not effective on mammalian ryandine receptor isoforms might interact with insect channels and provide a template for a new class of insecticides. The compounds will be based on naturally occurring peptides which specifically and reversibly modulate mammalian calcium channels.Read moreRead less
Sustaining Australia's sheep industry under climate change: modelling Australia's sheep flock response to climatic and economic constraints. This project aims to provide a quantitative assessment of the impact of climate change and economic conditions on the Australian sheep industry. This will be achieved by constructing a robust dynamic model of the Australian sheep flock capable of integrating biophysical and economic constraints across regional and national scales. Using historical and proje ....Sustaining Australia's sheep industry under climate change: modelling Australia's sheep flock response to climatic and economic constraints. This project aims to provide a quantitative assessment of the impact of climate change and economic conditions on the Australian sheep industry. This will be achieved by constructing a robust dynamic model of the Australian sheep flock capable of integrating biophysical and economic constraints across regional and national scales. Using historical and projected biophysical and economic inputs it will enhance the capacity of the Australian sheep industry for strategic planning in the face of projected climate change. This capacity is being actively sought by the peak sheep industry bodies in conjunction with our industry partner the Bureau of Rural Sciences.Read moreRead less
Self-Powered Wireless Sensor Networks, Enabling an Intelligent Agricultural Environment. Most animal production enterprises could be considerably more productive if the physiological status of each animal were to be continuously monitored, and the appropriate adjustments were made in real time. The proposed project will develop technologies that will enable continuous, real-time monitoring resulting in more efficient use of Australia's resources. Furthermore, research on wireless sensor network ....Self-Powered Wireless Sensor Networks, Enabling an Intelligent Agricultural Environment. Most animal production enterprises could be considerably more productive if the physiological status of each animal were to be continuously monitored, and the appropriate adjustments were made in real time. The proposed project will develop technologies that will enable continuous, real-time monitoring resulting in more efficient use of Australia's resources. Furthermore, research on wireless sensor networks, or ambient intelligence as it is sometimes called, is at the forefront of wireless communications and indeed ICT technology. This project will benefit Australia's ICT community both by training new professional and research leaders in this area, and by developing technologies that will further enable this rapidly growing field.Read moreRead less