A life-course approach to the nutrition-lifespan-reproduction nexus. This project aims to address the “cost of reproduction”, where lifespan and fecundity are negatively correlated. Bringing together nutritional geometry and evolutionary theory, to the project will produce an over-arching theory of why animals have finite lifespans and limited reproductive capacity. Benefits include developing research strategies for managing the nexus between diet, reproduction and lifespan in animals and human ....A life-course approach to the nutrition-lifespan-reproduction nexus. This project aims to address the “cost of reproduction”, where lifespan and fecundity are negatively correlated. Bringing together nutritional geometry and evolutionary theory, to the project will produce an over-arching theory of why animals have finite lifespans and limited reproductive capacity. Benefits include developing research strategies for managing the nexus between diet, reproduction and lifespan in animals and humans, placing Australia at the forefront of a paradigm shift in understanding the relationship between diet, reproduction and lifespan.Read moreRead less
Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evol ....Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evolutionary and mechanistic spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Read moreRead less
Unlocking telomere effects on life, death and fitness in a warming world. Few things in biology provoke such a strong desire for understanding as when adult death and fatal disease can be predicted early in life. A common factor linking early life stress, disease, ageing and time of death are telomeres, the protective regions at the end of each chromosome. This project aims to explicitly link telomere dynamics in free-living ectotherm populations with experimental approaches to advance our under ....Unlocking telomere effects on life, death and fitness in a warming world. Few things in biology provoke such a strong desire for understanding as when adult death and fatal disease can be predicted early in life. A common factor linking early life stress, disease, ageing and time of death are telomeres, the protective regions at the end of each chromosome. This project aims to explicitly link telomere dynamics in free-living ectotherm populations with experimental approaches to advance our understanding of parental and environmental effects on offspring telomeres and their effects later in life. This project will take advantage of one of the world’s longest datasets on ectotherm responses to climate to provide new knowledge of how telomeres affect fitness and the role that the environment plays.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100134
Funder
Australian Research Council
Funding Amount
$160,240.00
Summary
Sydney basin multi-purpose spectral analysis facility for evolutionary and ecological studies. This near infrared spectroscopy facility at The University of New South Wales will serve the Sydney area biological research community. Near infrared spectroscopy provides quick and robust estimates of key properties of animal and plant tissues, such as age, species and chemical composition.
Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new ....Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new knowledge about the unique biology of Australia's marsupial fauna.This project will provide significant benefits, including enhanced capacity for reproduction research in Australia, new international collaborations between Melbourne and Yale, and a new explanation for the puzzling role of inflammation in pregnancy.Read moreRead less
Genes in conflict in the social insects. Queen bees mate with 20 males, so it is in each male's interests to father female offspring that are more likely to become queens or reproductive workers. In contrast, queens want all workers to be sterile. This project will determine if some males pass on genes to offspring that have been modified so that their daughters are likely to become reproductive.
Structural reorganization of the hymenopteran mitochondrial genome. This study will be the first detailed investigation of the evolution of mt genome reorganization, and as such it will identify the processes that shape the evolution of a molecule widely used to interpret phylogeny. A description of the processes that lead to mt genome reorganization will have a substantial impact on our understanding in two areas of mt biology; (1) the discovery of new molecular phenomena that impact on the or ....Structural reorganization of the hymenopteran mitochondrial genome. This study will be the first detailed investigation of the evolution of mt genome reorganization, and as such it will identify the processes that shape the evolution of a molecule widely used to interpret phylogeny. A description of the processes that lead to mt genome reorganization will have a substantial impact on our understanding in two areas of mt biology; (1) the discovery of new molecular phenomena that impact on the organization and evolution of this genome, and (2) the interpretation of its phylogenetic content. It will establish our research group as a leader in the field of evolutionary genetics. Training of high quality students, with exposure to international researchers, will be a significant component of this program.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100214
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Re-evaluating evolution by examining developmental plasticity in response to the social environment. Our understanding of trait evolution is derived from our assumption that traits are a signal of male quality as they are costly to produce. The project will integrate this concept with a new theory stating that males shift their development to exploit the weaknesses of rivals; thereby leading to a more holistic understanding of evolution.
Adaptive plasticity and evolution: linking the genotype and the environment to understand phenotypic evolution and expression. Different environmental signals alter when and where specific genes are expressed, thereby altering the phenotype. This project will examine the differences in the timing and use of genes in response to cues of competition that result in differences between the sexes. This will increase our understanding of the role of genes in sexual evolution.
Discovery Early Career Researcher Award - Grant ID: DE120100836
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Oxidative stress as a physiological constraint on the pace of life histories. The project will draw on several areas of biology to answer a fundamental question: which mechanisms underlie the link between vital processes, like growth and reproduction, and rates of biological ageing? This research is needed to understand the basis of trade-offs that cause some individuals or species to age faster than others.