Understanding How the Hungry Brain Regulates Metabolism. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This process is orchestrated by neurons in the hypothalamus of the brain. This project aims to determine the role of the extracellular matrix that surrounds hypothalamic neurons and how this regulates energy homeostasis, an area of science that is completely unexplored. This project expects to identify the composition the extracellular m ....Understanding How the Hungry Brain Regulates Metabolism. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This process is orchestrated by neurons in the hypothalamus of the brain. This project aims to determine the role of the extracellular matrix that surrounds hypothalamic neurons and how this regulates energy homeostasis, an area of science that is completely unexplored. This project expects to identify the composition the extracellular matrix within the hypothalamus and discover how it regulates energy homeostasis. The outcomes of this project are to provide new knowledge in understanding how the brain regulates metabolism, to promote population health & wellbeing, develop new technologies and training the next generation of researchers.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101503
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Design of a biologically inspired running and climbing robotic lizard. Watch any movie and it will tell you that robots are the future. The trouble is that recent attempts to build running and climbing robots have had limited success. This project explores locomotion of lizards to improve upon shortfalls in current robotic design, to build biologically inspired robots capable of running and climbing up and down walls.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100206
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged i ....Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged imaging of significant physiological or biophysical events. Expected outcomes include high impact discoveries and publications in fundamental research, rapid solutions for industry-focussed projects and opportunities for collaboration, research and development. The imaging is expected to reveal key scientific insights and showcase biology to the public.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a vi ....Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a visually cluttered world, from insects to humans or autonomous vehicles.Read moreRead less
The control of chromosome division during female meiosis. Mammalian eggs are stored life-long and finally mature in the hours before ovulation. This project examines how the chromosomes in the egg are separated properly so as to produce a mature egg capable of being fertilized by a sperm. Often in eggs chromosome division is imprecisely executed, and this project will help us understand why this occurs.
Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowle ....Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowledge of previously intractable developmental processes, training of future scientists and development of international collaborations. This should provide enhanced imaging capacity, a higher quality scientific workforce and position Australia at the forefront of developmental biology.
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Australian Laureate Fellowships - Grant ID: FL140100197
Funder
Australian Research Council
Funding Amount
$2,970,898.00
Summary
Revealing the invisible: new principles of vision in Australian animals. Revealing the invisible: new principles of vision in Australian animals. This project aims to reveal how the visual systems of marine creatures from the Great Barrier Reef receive and interpret colour and polarisation information, much of which is invisible to the human eye. It aims to utilise this data to tackle fundamental questions in neuroscience and inform bio-inspired camera design and machine-vision solutions. The re ....Revealing the invisible: new principles of vision in Australian animals. Revealing the invisible: new principles of vision in Australian animals. This project aims to reveal how the visual systems of marine creatures from the Great Barrier Reef receive and interpret colour and polarisation information, much of which is invisible to the human eye. It aims to utilise this data to tackle fundamental questions in neuroscience and inform bio-inspired camera design and machine-vision solutions. The resulting new generation of polarisation cameras will be used to characterise the environments, animals and brains that inspired them in the first place. This will help the understanding of how nervous systems convey information and may improve our ability to detect dysfunction in neurons and other cells.Read moreRead less
Stomatopods v Cephalopods: discovery from an information coding arms-race. This proposal aims to unlock the power of a 400 million year old evolutionary arms race between two of earth's most successful predators, cephalopods (e.g. octopus) and mantis shrimp (stomatopods). New knowledge in vision (sensor design), neural coding (circuits and information flow) and behavioural (decisions and actions) innovations from these two groups will have fundamental and applied outcomes. The interdisciplinary ....Stomatopods v Cephalopods: discovery from an information coding arms-race. This proposal aims to unlock the power of a 400 million year old evolutionary arms race between two of earth's most successful predators, cephalopods (e.g. octopus) and mantis shrimp (stomatopods). New knowledge in vision (sensor design), neural coding (circuits and information flow) and behavioural (decisions and actions) innovations from these two groups will have fundamental and applied outcomes. The interdisciplinary and comparative nature of the project aims to amplify outcomes in questions of efficient neural coding, optical design and bio-inspired solutions. Benefits from the study include GPS-free navigation in marine engineering and rapid exposure of research results to millions of people through existing communication programs. Read moreRead less
New dimensions in colour and polarisation vision on The Great Barrier Reef. Many animals possess colour vision that outperforms humans and some also have a type of vision we lack altogether, polarisation vision. By comparing design and discovering strategies from the sensory systems of animals on The Great Barrier Reef, the project will enhance our knowledge of their sensory world, their ecosystem and broader visual neuroscience.