A mathematical model of calcium signalling in single cells and in multicellular systems. Calcium released from stores inside cells plays a vital signalling role in living organisms. It initiates cell division after fertilization, mediates communication and learning in the nervous system, causes contraction in the muscular walls of arteries and plays an important but as yet poorly understood role in the information processing that occurs in systems of coupled glial cells. We will construct a uni ....A mathematical model of calcium signalling in single cells and in multicellular systems. Calcium released from stores inside cells plays a vital signalling role in living organisms. It initiates cell division after fertilization, mediates communication and learning in the nervous system, causes contraction in the muscular walls of arteries and plays an important but as yet poorly understood role in the information processing that occurs in systems of coupled glial cells. We will construct a unified mathematical model of calcium signalling in multicellular systems, starting from the known processes in single cells, and use it to gain insight into the functioning and possible dysfunctioning of calcium-mediated intercellular communication.Read moreRead less
Computational Reconstruction of Cardiac Pacemaker Activation and Atrial Propagation. This study seeks to develop accurate computer models of electrical activity in pacemaker and atrial cells of the heart, in order to understand how the heartbeat originates and propagates across the atria during normal and abnormal rhythms. In Australia, atrial fibrillation represents the most common form of chronic cardiac arrhythmia encountered in clinical practice, as well as being a major risk factor in strok ....Computational Reconstruction of Cardiac Pacemaker Activation and Atrial Propagation. This study seeks to develop accurate computer models of electrical activity in pacemaker and atrial cells of the heart, in order to understand how the heartbeat originates and propagates across the atria during normal and abnormal rhythms. In Australia, atrial fibrillation represents the most common form of chronic cardiac arrhythmia encountered in clinical practice, as well as being a major risk factor in stroke. Accurate computer modelling of normal and abnormal heart rhythms will provide greater insights into the development of antiarrythmic drugs as well as advancing knowledge of key electrical phenomena in the heart.Read moreRead less
Modelling, Identification and Control of Complex Networks. Australia has been well known for its leading research in systems and control and many real-world applications in, for instance, telecommunications, defence, power grids and life sciences. This project will further promote Australia's leading position in the emerging new research field - complex networks by theoretical breakthrough in modelling, identification and control of complex networks, and cutting-edge platform technology that can ....Modelling, Identification and Control of Complex Networks. Australia has been well known for its leading research in systems and control and many real-world applications in, for instance, telecommunications, defence, power grids and life sciences. This project will further promote Australia's leading position in the emerging new research field - complex networks by theoretical breakthrough in modelling, identification and control of complex networks, and cutting-edge platform technology that can help Australian energy industry to reduce greenhouse emissions. It will also result in education of the next generation research leaders in this emerging field.Read moreRead less
Dynamic Analysis and Control for Hybrid Systems and Networks. Hybrid systems are now accepted as the best way to model many high-tech situations in transport, energy management, networking, household and industrial automation. This project will develop the theoretical tools needed to ensure such systems operate stably and efficiently despite imperfections and outside disturbances.
Generalised quantum models of complexity with application to cognitive systems. Non-separable systems surround us. Our transportation, taxation, schooling, environmental and social policies are all interrelated, and it is increasingly recognised that we cannot consider them in isolation. Such systems are generally deemed complex, and it is often impossible to separate them from one another. Despite this, many of our most advanced modelling techniques are grounded in principles of separability a ....Generalised quantum models of complexity with application to cognitive systems. Non-separable systems surround us. Our transportation, taxation, schooling, environmental and social policies are all interrelated, and it is increasingly recognised that we cannot consider them in isolation. Such systems are generally deemed complex, and it is often impossible to separate them from one another. Despite this, many of our most advanced modelling techniques are grounded in principles of separability and non-contextuality. This project will develop a new set of models of non-separable systems and complexity that will in turn lead to new frontier technologies and theories.Read moreRead less
Occupational Measures Approach to Long Run Average and Singularly Perturbed Optimal Control Problems. Problems of optimal control of long-run average and singularly perturbed systems arise in many applications. The project will lead to the development of new linear programming based techniques for analyzing these problems (including problems intractable so far) and finding their numerical solutions. The new techniques will have a potential to be further developed into software that can benefit A ....Occupational Measures Approach to Long Run Average and Singularly Perturbed Optimal Control Problems. Problems of optimal control of long-run average and singularly perturbed systems arise in many applications. The project will lead to the development of new linear programming based techniques for analyzing these problems (including problems intractable so far) and finding their numerical solutions. The new techniques will have a potential to be further developed into software that can benefit Australian industries and technologies. The proposed topic is in the focus of interest of many eminent researchers around the world and the dissemination of our results will further improve Australia's standing in the international research community. Read moreRead less
Service-oriented negotiation and coordination in multi-agent systems. Australia has a strong competitive advantage in the area of agent software. The outcomes of this project will provide an improved platform for services in application areas such as finance, e-commerce, tourism, and multi-platform media. More broadly, the work proposed here will enable the IT industry in Australia, and Melbourne specifically, to adopt and utilise agent-technology in developing the complex software that is inc ....Service-oriented negotiation and coordination in multi-agent systems. Australia has a strong competitive advantage in the area of agent software. The outcomes of this project will provide an improved platform for services in application areas such as finance, e-commerce, tourism, and multi-platform media. More broadly, the work proposed here will enable the IT industry in Australia, and Melbourne specifically, to adopt and utilise agent-technology in developing the complex software that is increasingly required to meet the needs of the software-driven knowledge economy of the 21st century.Read moreRead less
Retracing the Early Evolution of Metazoa using Novel Methods and Strategies. Metazoa is one of the best-characterised groups of species in terms of its morphology, fossil record, development, and genetic make-up, but the phylogeny remains obscure because the fossil record is incomplete and because molecular phylogenetic methods have not yet been developed with the complexity of genomic data in mind. We will develop methods and strategies for the analysis of whole genomes, and use them in studies ....Retracing the Early Evolution of Metazoa using Novel Methods and Strategies. Metazoa is one of the best-characterised groups of species in terms of its morphology, fossil record, development, and genetic make-up, but the phylogeny remains obscure because the fossil record is incomplete and because molecular phylogenetic methods have not yet been developed with the complexity of genomic data in mind. We will develop methods and strategies for the analysis of whole genomes, and use them in studies of the mitochondrial genome. We will infer the animal phylogeny, and use it to chart the evolution of animal morphology and development, and the evolution of mitochondrial genetic codes, gene order, and nucleotide content.Read moreRead less
Constructive control of interconnected systems. Sustainability and competitiveness of the Australian industry critically depends on the progress in the technological area of distributed information processing and control. This project will contribute to the existing Australian research effort in this area by advancing the control systems theory which underpins many cutting edge technologies in areas of immediate national interest.
A mathematical model relating neural activity to cerebral blood flow. An ageing population is increasingly prone to neurodegenerative disease and the associated mental impairment can severely disrupt the lives of both the sufferers and the carers. Non-invasive brain imaging techniques are used to both diagnose and supervise treatment of such disease, but at present a lack of understanding of the underlying physiology leaves these methods open to criticism. The construction of a detailed quanti ....A mathematical model relating neural activity to cerebral blood flow. An ageing population is increasingly prone to neurodegenerative disease and the associated mental impairment can severely disrupt the lives of both the sufferers and the carers. Non-invasive brain imaging techniques are used to both diagnose and supervise treatment of such disease, but at present a lack of understanding of the underlying physiology leaves these methods open to criticism. The construction of a detailed quantitative model of the basic processes underlying this imaging will enable precise interpretation of such brain scans and increase their usefulness both as a research and as a therapeutic tool.Read moreRead less