The vision we rely on every day to read and recognise faces depends upon the health of the central portion of our retina, the macula. Age-related Macular Degeneration (AMD) is the leading cause of blindness in Australia and the western world. Researchers at the Australian National University are collaborating to bring a new test for AMD severity to the market within 3 years. The objective is to provide doctors with a rapid, cost-effective tool to help them manage treatment.
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
The Relationship Between Maternal And Infant Dietary Intake Of Fermentable Fibre, Gut Microbiota, Short Chain Fatty Acids And Allergic Disease And Asthma: A Population-derived Birth Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$871,700.00
Summary
The proposed study will involve the Barwon Infant Study (BIS) cohort of 1074 infants to provide the first systematic investigation of the hypotheses that the epidemic of allergic disease and asthma in many parts of the world relates to the paucity of fermentable fibre in the modern diet, and that the protective effect of fermentable fibre is mediated by changes in the organisms that colonise the gut and the metabolites that they produce.
Microbial community stability dynamics to environmental triggers. This project aims to advance our knowledge of the structural/functional dynamics of complex microbial communities by defining stability in response to environmental influences such as nutrient stress, pathogen invasion and antibiotics/chemicals. Using innovative microbial consortia modelling, to identify communities at risk of homeostatic disruption, we will develop and test pre-emptive microbial manipulation strategies for restor ....Microbial community stability dynamics to environmental triggers. This project aims to advance our knowledge of the structural/functional dynamics of complex microbial communities by defining stability in response to environmental influences such as nutrient stress, pathogen invasion and antibiotics/chemicals. Using innovative microbial consortia modelling, to identify communities at risk of homeostatic disruption, we will develop and test pre-emptive microbial manipulation strategies for restoring community stability. This project will yield significant global impact and economic/health benefit for humans and animals.Read moreRead less
Flipping the mattress: infinite polyurethane recycling by synthetic biology. Australia is covered in billions of tonnes of plastic and yet <10% is recycled today. Polyurethane (PU) is ubiquitous in our everyday lives, from lacquer coatings to elastane clothing to durable foam padding in car seats, cushions and mattresses. Currently, there are few avenues for PU recycling and much ends up in landfill e.g., a single mattress produces 15-20kg of PU foam waste. Luckily, biodegradation of PU can occu ....Flipping the mattress: infinite polyurethane recycling by synthetic biology. Australia is covered in billions of tonnes of plastic and yet <10% is recycled today. Polyurethane (PU) is ubiquitous in our everyday lives, from lacquer coatings to elastane clothing to durable foam padding in car seats, cushions and mattresses. Currently, there are few avenues for PU recycling and much ends up in landfill e.g., a single mattress produces 15-20kg of PU foam waste. Luckily, biodegradation of PU can occur naturally via various microbial means and from insects, like Galleria mellonella larvae. The overall aim of this research project is to understand plastic biodegradation and translate nature’s solutions into flexible and efficient synthetic enzyme technologies that can sustainably recycle commonly used PU foams. Read moreRead less
A systems approach to dissect the pathogenicity and host specificity of the Fusarium wilt pathogen, Fusarium oxysporum. The pathogenic fungus Fusarium oxysporum causes wilt disease in many plant species, including many that are important for Australian agriculture. Developing environmentally friendly disease protection strategies against this pathogen requires a clear understanding of infection strategies used by the fungus to invade its host. This project, along with a parallel project in host ....A systems approach to dissect the pathogenicity and host specificity of the Fusarium wilt pathogen, Fusarium oxysporum. The pathogenic fungus Fusarium oxysporum causes wilt disease in many plant species, including many that are important for Australian agriculture. Developing environmentally friendly disease protection strategies against this pathogen requires a clear understanding of infection strategies used by the fungus to invade its host. This project, along with a parallel project in host resistance mechanisms, will provide the basis for development of a world leading platform in mechanisms of fungal pathogenicity and virulence and plant disease resistance/susceptibility. Application of the knowledge gained in this project to other host-pathogen interactions will thereby provide opportunities for improved crop protection and biosecurity.Read moreRead less
Biogeochemistry of ferruginous duricrusts. The project is focussed on the examination and application of microbial iron cycling in the formation of geologically stable, iron duricrusts in tropical regimes. The aim of the project is to develop a site-scale bioremediation strategy for iron ore mines by re-establishing canga, which are ‘ancient’ distinct ecosystems possessing unique plant species rarely found on Earth. This university-industry collaboration aims to produce economic benefits for the ....Biogeochemistry of ferruginous duricrusts. The project is focussed on the examination and application of microbial iron cycling in the formation of geologically stable, iron duricrusts in tropical regimes. The aim of the project is to develop a site-scale bioremediation strategy for iron ore mines by re-establishing canga, which are ‘ancient’ distinct ecosystems possessing unique plant species rarely found on Earth. This university-industry collaboration aims to produce economic benefits for the world’s iron mining industry through advanced training in mining-related research, and through the completion of the mining life cycle by site remediation, enhancing Australia’s position as a global leader in providing innovative solutions to today’s mining challenges.Read moreRead less
Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnol ....Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnology, bioremediation, and synthetic biology where evolution can be inhibited or exploited, respectively.Read moreRead less
Molecular fossils, environmental genomics and the natural history of an Australian salt lake. Increasing salinity of lakes is a critical problem for sustainable water supply in Australia. To comprehend the consequences of human-induced salinization, it is crucial to understand salt lakes at their most fundamental level. This project develops pioneering technologies to elucidate the microbial ecology and geochemistry of salt lakes in unprecedented detail. It will open new pathways to unravel how ....Molecular fossils, environmental genomics and the natural history of an Australian salt lake. Increasing salinity of lakes is a critical problem for sustainable water supply in Australia. To comprehend the consequences of human-induced salinization, it is crucial to understand salt lakes at their most fundamental level. This project develops pioneering technologies to elucidate the microbial ecology and geochemistry of salt lakes in unprecedented detail. It will open new pathways to unravel how microbial ecosystems adapt to increasing salinization, and how they reacted to climate fluctuations in the past. Students will gain multidisciplinary skills in environmental genomics, proteomics and geochemistry, a unique combination that will become decisive for understanding and preserving ecosystems on our continent.Read moreRead less