Developing and testing a novel biological reduction cell to remediate heavy metal and acid-containing industrial and mine leachates. Echo Remediation Ltd. has a new reduction cell that uses sulfur and bacteria to remove heavy metals and acidity from mine leachates, but development is now required to make it viable. The project aims to optimise the process using molecular approaches to study the effects of operating conditions on the bacterial communities. As part of the investigation, active iro ....Developing and testing a novel biological reduction cell to remediate heavy metal and acid-containing industrial and mine leachates. Echo Remediation Ltd. has a new reduction cell that uses sulfur and bacteria to remove heavy metals and acidity from mine leachates, but development is now required to make it viable. The project aims to optimise the process using molecular approaches to study the effects of operating conditions on the bacterial communities. As part of the investigation, active iron reducers will be selected and introduced to the cell (in conjunction with chemical amendments) and their colonization monitored. The new technology once developed has the potential to be used at mine sites in Australia and overseas and its employment offers a sustainable, biological "green" approach to mine waste remediation.Read moreRead less
Integrating electrophysiology and molecular biology to understand the role of cell membranes in bacterial responses to chill and osmotic stress. Modern food manufacture is driven by competing demands: consumers prefer foods that are 'natural', i.e. having received minimal processing and containing less preservatives, and last, but are safe. Thus, a challenge is to find minimal sets of treatments and preservatives that limit microbial growth.
Current methods to for determining limits to microbi ....Integrating electrophysiology and molecular biology to understand the role of cell membranes in bacterial responses to chill and osmotic stress. Modern food manufacture is driven by competing demands: consumers prefer foods that are 'natural', i.e. having received minimal processing and containing less preservatives, and last, but are safe. Thus, a challenge is to find minimal sets of treatments and preservatives that limit microbial growth.
Current methods to for determining limits to microbial growth are time and consuming and empirical. We will assess the potential of a new method (MIFE) to rapidly measure limits of bacterial growth under combinations of treatments. At the same time we will study how cells, and in particular how the cell membrane, responds to these stresses to provide insights for the development of new, minimal - yet safe - food preservation technologies.
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Geochemical, physical and microbiological controls on zinc mobility and implications for bioremediation strategies in Western Tasmanian acid mine drainage. We propose to study heavy metal pollution (e.g., zinc, arsenic, iron, tin) and biogeochemical processes operating in acid mine drainage at the abandoned Mt Bischoff tin mine in Western Tasmania. The drainage waters at this site have pH values as low as 2, but contain an extensive and thriving natural biological community. We will evaluate w ....Geochemical, physical and microbiological controls on zinc mobility and implications for bioremediation strategies in Western Tasmanian acid mine drainage. We propose to study heavy metal pollution (e.g., zinc, arsenic, iron, tin) and biogeochemical processes operating in acid mine drainage at the abandoned Mt Bischoff tin mine in Western Tasmania. The drainage waters at this site have pH values as low as 2, but contain an extensive and thriving natural biological community. We will evaluate whether the natural biogeochemical processes operating at Mt Bischoff have the potential to remediate mine waters under the full gamut of climatic conditions, so as to evaluate whether the biota could be exported to other mine sites to help in ameliorating acid drainage problems.Read moreRead less
Community-level selection: Empirical tests in a microbial system. Given the profile of the question of community-level selection as a long-running controversy, the main benefit of the proposed work, which will critically test the idea in an empirical system, will be to increase recognition of Australia's position as a research nation in evolutionary biology. In exploring mechanisms of floc formation, a key component of wastewater treatment, the work will establish important foundations for impro ....Community-level selection: Empirical tests in a microbial system. Given the profile of the question of community-level selection as a long-running controversy, the main benefit of the proposed work, which will critically test the idea in an empirical system, will be to increase recognition of Australia's position as a research nation in evolutionary biology. In exploring mechanisms of floc formation, a key component of wastewater treatment, the work will establish important foundations for improving the efficiency of wastewater treatment. Improvement in performance of only a few percent will bring important economic savings. This is evidenced by recent commitment of >$US 230 billion to improving the efficiency of wastewater treatment in Germany, Italy and Spain over 5 years.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to ....Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to a broad suite of environmental perturbations (temperature, nutrients, contaminants), will generate stress-response data that can be incorporated alongside eukaryotic data in environmental assessments, greatly improving the ecological relevance and reliability of risk and vulnerability assessments.Read moreRead less
Efficacy Of Education And Advice Delivered By Text Message To Aid Smoking Cessation
Funder
National Health and Medical Research Council
Funding Amount
$538,395.00
Summary
A high proportion of smokers indicate a desire to stop smoking and report having made attempts to quit. However, most attempts are not successful and new methods are needed to support motivated smokers and improve success rates. This project evaluates the use of text messages to deliver advice and support to smokers motivated to stop smoking. We aim to understand if and how this promosing new intervention helps smokers to quit.
Improved management of coastal plankton systems by ancient DNA technology. This project aims to assemble comprehensive long term Australian plankton records spanning 50 to 1000 years, by applying ancient DNA technology to dated sediment depth cores. Long-term data for Australian coastal and estuarine waters are sparse, so cannot be used for management of fisheries, tourism or urban development. Long-term records are essential to understand how disruptive algal and jellyfish blooms, introduced sp ....Improved management of coastal plankton systems by ancient DNA technology. This project aims to assemble comprehensive long term Australian plankton records spanning 50 to 1000 years, by applying ancient DNA technology to dated sediment depth cores. Long-term data for Australian coastal and estuarine waters are sparse, so cannot be used for management of fisheries, tourism or urban development. Long-term records are essential to understand how disruptive algal and jellyfish blooms, introduced species and increased human use of coastal resources affect dynamic plankton ecosystems. This project’s findings are expected to explore cyclical patterns, define range expansions and understand and manage how dynamic coastal ecosystems respond to multistressor anthropogenic change. Findings will improve understanding of how dynamic marine environments retain their biodiversity values and critical ecological functions.Read moreRead less
Understanding algal bloom microbiome function to improve seafood safety. Current phytoplankton ecological theory is derived primarily from lab cultures, but in nature phytoplankton have unique microbiomes that support their growth and ongoing ocean primary production. This project aims to establish the structure and function of these natural microbiomes, and how they contribute to seafood poisoning caused by bacteria and algal biotoxins. Using advanced flow cytometry with single-cell microbial ....Understanding algal bloom microbiome function to improve seafood safety. Current phytoplankton ecological theory is derived primarily from lab cultures, but in nature phytoplankton have unique microbiomes that support their growth and ongoing ocean primary production. This project aims to establish the structure and function of these natural microbiomes, and how they contribute to seafood poisoning caused by bacteria and algal biotoxins. Using advanced flow cytometry with single-cell microbial profiling, we will sample nano-scale plankton microbiomes and synthetic microbiome phylogenomics to the link between microbiomes and seafood poisoning outbreaks. The outcomes will underpin enhanced predictive modelling of seafood risk to ensure the safety and export security of Australia's $2 billion seafood industry.Read moreRead less