Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less
Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Towards Generalisable and Unbiased Dynamic Recommender Systems. This project aims to develop the foundations, including models, methodology, and algorithms for building generalisable and unbiased dynamic recommender systems to facilitate intelligent decision-making, prompt contextualised and personalised strategic plans, and support context-aware action recourse. To ensure that fundamental principles, such as fairness and transparency, are respected, a set of algorithms and techniques are propos ....Towards Generalisable and Unbiased Dynamic Recommender Systems. This project aims to develop the foundations, including models, methodology, and algorithms for building generalisable and unbiased dynamic recommender systems to facilitate intelligent decision-making, prompt contextualised and personalised strategic plans, and support context-aware action recourse. To ensure that fundamental principles, such as fairness and transparency, are respected, a set of algorithms and techniques are proposed to develop recommender systems in a more responsible manner. The result of this project will not only maintain Australia's leadership in this frontier research area, but also serve as an excellent vehicle for the education and training of Australia's next generation of scholars and engineers.Read moreRead less