Investigation Of Small Molecule Interactions With The Human Leukocyte Antigen And Their Role In Non-infectious Disease
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The Human Leukocyte Antigens (HLA) play a key role in the immune system helping the body differentiate healthy from diseased cells. Numerous autoimmune diseases and adverse drug reactions are associated with specific HLA variants. This study seeks to unlock the mechanisms behind these diseases, investigating how small molecules including drugs interact with the HLA to make healthy body cells seem foreign. This research has the potential to inform strategies for disease avoidance and management.
Investigation Of The Roles Of Foxn1, Wnts And Autophagy In The Development And Function Of Thymic Epithelial Cells.
Funder
National Health and Medical Research Council
Funding Amount
$220,222.00
Summary
The immune system usually protects the body from infections. Occasionally, the immune system mistakenly recognises components of the body as foreign and attacks them, resulting in autoimmune diseases such as diabetes, multiple sclerosis and arthritis. An organ called the thymus is responsible for educating the immune system, and preventing autoimmune diseases. The proposed project will explore how the thymus develops, and how it teaches the immune system to ignore normal components of the body.
Tracking Endogenous Presentation Of MHC Class-II-Restricted Viral Epitopes
Funder
National Health and Medical Research Council
Funding Amount
$165,436.00
Summary
CD4+ T cells play an important role in controlling viral infections. Proteins from viruses are processed into small pieces by immune stimulating cells and these are then displayed on special molecules of the immune stimulating cells for the CD4+ T cells to recognise and respond to. This project aims to establish the various pathways by which the immune stimulating cells process the proteins and present them to the CD4+ T cells.
Harnessing Systems Biology By Integrating Proteomics And Immunopeptidomics To Understand Prostate Cancer Carcinogenesis, Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
This ECF proposal aims to systematic profile to proteomic compositions of prostate normal, and cancer cells, and utilise such data to develop innovative systems biology models that will enable accurate prediction of tumour associate antigen (TAA) presentation for both aggressive and nonaggressive prostate cancer. The outcomes of this project will generate urgently needed knowledge for understanding TAA presentation and contribute to identification of tractable targets for vaccine development.