Enhancing Treatment Effectiveness In Acute Stress Disorder
Funder
National Health and Medical Research Council
Funding Amount
$235,330.00
Summary
Posttraumatic stress disorder (PTSD) is the most common psychiatric condition to develop after trauma. Early intervention of PTSD following a trauma is indicated because chronic PTSD can be resistant to treatment. Early intervention is possible because acute stress disorder immediately after a trauma identifies those people who will develop chronic PTSD. Although cognitive behaviour therapy of acute stress disorder can effectively prevent PTSD in many cases, many people do not benefit from this ....Posttraumatic stress disorder (PTSD) is the most common psychiatric condition to develop after trauma. Early intervention of PTSD following a trauma is indicated because chronic PTSD can be resistant to treatment. Early intervention is possible because acute stress disorder immediately after a trauma identifies those people who will develop chronic PTSD. Although cognitive behaviour therapy of acute stress disorder can effectively prevent PTSD in many cases, many people do not benefit from this treatment because this treatment involves exposure to distressing memories and emotions, and this contributes to many people dropping out of treatment. This project aims to extend the utility of early intervention following trauma by assessing approaches that can be used by most trauma survivors. The project compares early intervention with either exposure, cognitive therapy, combined exposure and cognitive therapy, or supportive counseling. All therapy will be conducted in the initial four weeks and will comprise 6 sessions. Assessments will be conducted posttreatment, six-months follow-up, and one-year follow-up. The outcomes of this project will have significant public health benefits because they will lead to increased treatment effectiveness for acutely traumatized people, and will markedly reduce the incidence of PTSD in the community.Read moreRead less
Panic Disorder: Neurobiology And Mechanisms Of Cardiac Risks
Funder
National Health and Medical Research Council
Funding Amount
$414,375.00
Summary
Some people are subject to episodes of recurring, often inexplicable anxiety which are very unpleasant and accompanied by physical symptoms such as sweating, palpitations, tremor and a sensation of suffocation. Recurring attacks over a period of months, or years, forms the basis for the diagnosis of panic disorder. It has until recently been felt that although panic disorder was distressing and disabling, it did not constitute a risk to life. Sufferers often fear that they have heart disease, be ....Some people are subject to episodes of recurring, often inexplicable anxiety which are very unpleasant and accompanied by physical symptoms such as sweating, palpitations, tremor and a sensation of suffocation. Recurring attacks over a period of months, or years, forms the basis for the diagnosis of panic disorder. It has until recently been felt that although panic disorder was distressing and disabling, it did not constitute a risk to life. Sufferers often fear that they have heart disease, because of the nature of their symptoms, but have been reassured that this is not the case. Recent epidemiological studies, however, indicate that there is an increased risk of heart risk in patients with panic disorder. Our hypotheses in this research are as follows: That panic disorder is characterised by increased release of the brain chemical messenger, serotonin, which is reversed by drug treatment with the most widely used class of drugs for this disorder, selective serotonin reuptake blockers That changes in an automatic stimulatory part of the nervous system, has primary importance in the disorder, in both genetically predisposing to panic disorder, and in mediating heart risk. That weight gain during therapy, a very common problem, is due to inhibition of brain serotonin release. We will test all these propositions using state of the art clinical scientific methods. Panic disorder has an important cardiological dimension which needs to be better understood for cardiac protection to be achieved in panic disorder patients. Our study of the mechanisms of cardiac risk should provide this. We will also provide very direct, valid measurements of chemical messenger release in the brain of panic disorder sufferers, using our unique methods. These should give a new understanding of the brain chemistry abnormalities of panic disorder, and the mechanism of action of the selective serotonin reuptake inhibitors.Read moreRead less
Depression, Anxiety And Somatic Distress: Syndromal Structure And Relationship To Onset Of Clinical Disorder
Funder
National Health and Medical Research Council
Funding Amount
$224,085.00
Summary
The project aims to identify the principal dimensions or syndromes underlying symptoms of psychological distress (negative emotional states such as depression, anxiety, stress and fatigue). We plan to use an intensive longitudinal design to examine how these syndromes develop into episodes of clinical disorder. We expect that episodes of disorder will be predicted not only by closely related syndromes, but also by other causally related syndromes - for example, a period of increased anxiety and ....The project aims to identify the principal dimensions or syndromes underlying symptoms of psychological distress (negative emotional states such as depression, anxiety, stress and fatigue). We plan to use an intensive longitudinal design to examine how these syndromes develop into episodes of clinical disorder. We expect that episodes of disorder will be predicted not only by closely related syndromes, but also by other causally related syndromes - for example, a period of increased anxiety and stress may precipitate a depressive disorder. This information is important for understanding the aetiology of clinical disorders, for refining diagnostic criteria, and for the prediction and prevention of disorder. We also plan to collect information about the degree of disability that people suffer and the type of health services they access at various levels of severity of each syndrome. We expect that subclinical levels of some syndromes will be associated with substantial impairment and service usage, but that for other syndromes impairment will be minimal until clinical levels of severity are reached. This information will give a more complete picture of the community-wide burden of emotional distress, and will be directly relevant to health planning and policy.Read moreRead less
A Prospective Study Of Traumatic Stress In Children Involved In Motor Vehicle Accidents
Funder
National Health and Medical Research Council
Funding Amount
$185,889.00
Summary
Motor vehicle accidents (MVAs) are relatively frequent major life trauma that represent significant life threatening experiences. Not surprisingly evidence suggests that MVAs represent a frequent trigger for the development of post traumatic stress disorder (PTSD), although studies have typically focussed upon adult survivors. Local statistics indicate a significant proportion of children will experience a MVA of sufficient severity to warrant attendance at hospital. This project is of significa ....Motor vehicle accidents (MVAs) are relatively frequent major life trauma that represent significant life threatening experiences. Not surprisingly evidence suggests that MVAs represent a frequent trigger for the development of post traumatic stress disorder (PTSD), although studies have typically focussed upon adult survivors. Local statistics indicate a significant proportion of children will experience a MVA of sufficient severity to warrant attendance at hospital. This project is of significance because it will provide badly needed information about the prevalence and course of emotional and behavioural problems in children following exposure to a serious MVA. More broadly the study should provide valuable information on post-traumatic stress responses in children. Furthermore, it will enable us to identify the factors that place children at particular risk of developing psychological problems following a MVA. This will provide information to help design of interventions to prevent the development of PTSD and other forms of psychopathology following MVAs. Such data will also permit identification of those children who are at particular risk of psychological morbidity after MVA trauma and for whom preventive interventions are most likely to be beneficial.Read moreRead less
The Prevention Of Anxiety And Related Disorders: Long Term Follow-up Of Temperamentally At-risk Preschoolers.
Funder
National Health and Medical Research Council
Funding Amount
$391,476.00
Summary
Anxiety and related disorders such as depression provide a tremendous cost to the individual sufferer and to Australian society. While previous research has focussed on treatment of these conditions, little work has addressed the possibility of preventing these disorders before they interfere with an individual's life. There is growing evidence that children who are shy, withdrawn and inhibited at a very young age are more likely than other children to develop anxiety disorders in later childhoo ....Anxiety and related disorders such as depression provide a tremendous cost to the individual sufferer and to Australian society. While previous research has focussed on treatment of these conditions, little work has addressed the possibility of preventing these disorders before they interfere with an individual's life. There is growing evidence that children who are shy, withdrawn and inhibited at a very young age are more likely than other children to develop anxiety disorders in later childhood and a variety of related disorders in adulthood. In a previous NHMRC-funded grant, we have developed a brief parent education program to modify this personality style in young children. Early results are very promising and it appears that we have been able to help these withdrawn children to become more outgoing. This next proposal aims to follow these children over the coming years to see whether they are also less likely to develop mental health problems than children whose parents have not received the educational program are. We will be observing the children in a laboratory setting and at school at three, yearly intervals. At each point, we will compare withdrawn children whose parents have gone through the education program with those who haven't.Read moreRead less
The Effectiveness Of An Early Intervention And Prevention Strategy For Anxiety And Depressive Disorders.
Funder
National Health and Medical Research Council
Funding Amount
$119,924.00
Summary
Adult anxiety and depressive disorders are common, cause significant distress to sufferers and cost to the community, and generally begin in childhood. Prior research has shown that children who exhibit higher than average levels of anxiety in their late childhood are at risk for developing anxiety and depressive disorders as they grow older. However if at risk children can learn skills to better manage their anxiety, the chance that they will continue to experience significant anxiety problems ....Adult anxiety and depressive disorders are common, cause significant distress to sufferers and cost to the community, and generally begin in childhood. Prior research has shown that children who exhibit higher than average levels of anxiety in their late childhood are at risk for developing anxiety and depressive disorders as they grow older. However if at risk children can learn skills to better manage their anxiety, the chance that they will continue to experience significant anxiety problems is greatly reduced. For example, school-based skills-building programs run by specialist mental health professionals have been shown to reduce the rate of existing anxiety disorder and prevent the onset of new anxiety disorders across middle to late childhood and early adolescence. The proposed study will aim to show that a school-based program, run by school counsellors, can prevent the development of anxiety and depressive disorders in late adolescence. In other words, the aim is to demonstrate whether the benefit of the program can be achieved across the wider school-aged population when conducted wholly within the education sector. This outcome is significant, not only in its potential to reduce distress to a large number of adolescents and their families, but in reducing costs to the community in terms of reduced disability and reduced need for health care and specialist mental health treatment.Read moreRead less
I am a mental health researcher who designs and tests the effectiveness of methods to encourage help seeking, to intervene early and prevent the development of psychiatric disorders, and who develops technological tools to assist consumers to manage their
Prof Jorm is a psychiatric epidemiologist working on prevention of and early intervention with common mental disorders, including addiction and depression and who is involved in translating research results into population health practice.