Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration ....Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration into complex neural networks as well as, (iv) the organisation of neurons into larger 3-dimensional brain structures, namely folding of the human cortex. Further, biomaterials developed here have commercialisation potential, targeted at standardizing the culturing of human stem cells to defined neural populations.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100150
Funder
Australian Research Council
Funding Amount
$595,280.00
Summary
Advanced multifunctional photoelectron spectroscopy platform. This project aims to establish a new integrated facility that will allow researchers to characterise the surface structure and electronic properties of materials, which is essential for a complete understanding of their functionality. The development of the next generation of electronic, optical, and biomedical devices requires new materials with properties optimised for the particular application. This facility, to be housed in state ....Advanced multifunctional photoelectron spectroscopy platform. This project aims to establish a new integrated facility that will allow researchers to characterise the surface structure and electronic properties of materials, which is essential for a complete understanding of their functionality. The development of the next generation of electronic, optical, and biomedical devices requires new materials with properties optimised for the particular application. This facility, to be housed in state-of-the-art laboratories and managed as an open access resource, will meet the needs of a large number of innovative projects and enable advances in many fields including electronics, nanotechnology, solar energy, biotechnology and advanced materials.Read moreRead less
Enabling semiconductor nanowire technologies via 3D atomic-scale insight. Semiconductor nanowires (NWs) are nanotechnology building blocks that have the potential to transform solar cells, light emitting diodes, lasers and transistors, creating new industries in communications, energy and healthcare. The industrial development of NWs has been blocked by uncertainties in the relationships between their growth conditions, properties and atomic-scale structure. This project will address this chall ....Enabling semiconductor nanowire technologies via 3D atomic-scale insight. Semiconductor nanowires (NWs) are nanotechnology building blocks that have the potential to transform solar cells, light emitting diodes, lasers and transistors, creating new industries in communications, energy and healthcare. The industrial development of NWs has been blocked by uncertainties in the relationships between their growth conditions, properties and atomic-scale structure. This project will address this challenge by establishing a rigorous framework for these relationships. The project aims to achieve this by harnessing the unique power of atom probe microscopy to reveal the NW structure in three dimensions, and at atomic-resolution. The project aims to place Australian research at the frontier of development of these future industries.Read moreRead less
Making every electron count in atomic resolution microscopy. The development of aberration-corrected electron microscopy, which allows individual atom imaging with unprecedented precision, was recognised by the 2011 Wolf Prize in Physics. However, only a very limited amount of the wealth of information obtainable from such microscopes is currently exploited. By collecting a maximal data set of electrons scattered in manifold different ways and using the fundamental theory of electron-specimen in ....Making every electron count in atomic resolution microscopy. The development of aberration-corrected electron microscopy, which allows individual atom imaging with unprecedented precision, was recognised by the 2011 Wolf Prize in Physics. However, only a very limited amount of the wealth of information obtainable from such microscopes is currently exploited. By collecting a maximal data set of electrons scattered in manifold different ways and using the fundamental theory of electron-specimen interaction, this project will realise the huge potential of this untapped data. This will improve the utility of scanning transmission electron microscopy far beyond its current level. Applying these new techniques will expand our understanding of the structure and function of advanced materials.Read moreRead less
Interatomic bonding in aluminium alloys. This project proposes a new theory about the formation of strengthening precipitates in alloys. It will be tested using new techniques for measuring bonds between atoms and Australia's most advanced electron microscopes. It will remove the guesswork from the processing and design of commercial alloys.
Electro-mechanics of natural load-bearing materials: understanding mechanisms of toughening, remodelling, and self-healing. Nature provides some of the most advanced functional structural materials, with the capability to remodel and strengthen under changing loads. The origins of the functional properties which allow them to do this will be explored, providing the possibility of developing materials which mimic this behaviour.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
Imaging light elements, dopants and vacancies. This project will pioneer techniques for seeing light atoms, such as oxygen in superconductors and lithium in lithium battery materials. Coming to understand the function of light elements in advanced materials is vital as such materials play a pivotal role in meeting the pressing challenges that beset us in energy management.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100036
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for hi ....A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for high-performance applications. The customised features of the proposed instrument are the first of its kind in Australia. The new knowledge developed through this project will significantly impact on scientific insights and practical applications of new materials related to physics, chemistry, biology, geology and engineering.Read moreRead less
'Designer defects' - A new approach to functional oxide interfaces. The conventional approach to metal oxide interfaces is 'perfection at all costs' with growth tuned to minimise defects and unwanted chemical intermixing. This project aims to turn this approach on its head by creating interfaces with 'designer defects' that become the critical portion of a functional device. This project proposes that one can promote functionality by making use of new physical properties that arise from the deli ....'Designer defects' - A new approach to functional oxide interfaces. The conventional approach to metal oxide interfaces is 'perfection at all costs' with growth tuned to minimise defects and unwanted chemical intermixing. This project aims to turn this approach on its head by creating interfaces with 'designer defects' that become the critical portion of a functional device. This project proposes that one can promote functionality by making use of new physical properties that arise from the deliberate introduction of structural and electronic mismatches at an interface. Such purposely induced 'designer defects' in epitaxial oxide thin films will allow new properties to be achieved in nanoscale layers. This is expected to lead to a new class of functional materials to be used in sensors and nanoelectronics.Read moreRead less