New Developments for Bayesian statistical models and computational methods. Bayesian methods of statistical analysis provide a flexible theory for addressing inference in the presence of uncertainty. Consequently Bayesian methods have enabled scientific discovery in areas characterised as complex systems where new developments in modelling and computational methods have been crucial. Significant barriers to further success involve challenges in formulating and validating models, dealing with l ....New Developments for Bayesian statistical models and computational methods. Bayesian methods of statistical analysis provide a flexible theory for addressing inference in the presence of uncertainty. Consequently Bayesian methods have enabled scientific discovery in areas characterised as complex systems where new developments in modelling and computational methods have been crucial. Significant barriers to further success involve challenges in formulating and validating models, dealing with large data sets, and developing efficient computational methods. The principal aim of this project is to develop new Bayesian modelling and computational methodology which address these challenges with broad application.Read moreRead less
Techniques to use stereo vision for improving person identification systems based on face recognition. The broad aim of this project is to use three-dimensional information available by processing images from stereo cameras in order to bridge the gap between constrained face recognition systems and viable systems that work well under varying illumination, changes in pose and variations in spectacles, facial hair and attire. Such a system will be useful in passenger verification at airports and a ....Techniques to use stereo vision for improving person identification systems based on face recognition. The broad aim of this project is to use three-dimensional information available by processing images from stereo cameras in order to bridge the gap between constrained face recognition systems and viable systems that work well under varying illumination, changes in pose and variations in spectacles, facial hair and attire. Such a system will be useful in passenger verification at airports and as a component of personal identification systems to counter terrorism. The key to successful face location and recognition is an effective combination of all data - range, luminance and colour - and techniques for this will be the discovered outcomes.Read moreRead less
Kernel methods for the analysis of whole bacterial genomes. This project addresses the fundamental scientific problem of the identification of regulatory regions and specific promoters within bacterial genomes, with a focus upon two organisms of great social, economic and bioterrism significance. From the machine learning perspective, the project will be the first to produce a kernel-based approach directly tailored to the problem of the detection of regulatory regions. The methods developed wil ....Kernel methods for the analysis of whole bacterial genomes. This project addresses the fundamental scientific problem of the identification of regulatory regions and specific promoters within bacterial genomes, with a focus upon two organisms of great social, economic and bioterrism significance. From the machine learning perspective, the project will be the first to produce a kernel-based approach directly tailored to the problem of the detection of regulatory regions. The methods developed will be made available through a straightforward web-based interface, allowing biologists throughout the world to utilize the approach as a tool to be applied to a progressively widening class of bacterial genomes, and even to eukaryotes. Read moreRead less
Ontologically-based Evaluation, Comparison and Engineering of Integrated Process Modelling Techniques. Integrated process modelling techniques such as UML and ARIS form the conceptual platform for many management and IT projects. Though most IS development tools contain these techniques, anecdotal evidence indicates many shortcomings. This project uses a well-established theory developed in philosophy and applied in information systems domains for the evaluation of these techniques. The expec ....Ontologically-based Evaluation, Comparison and Engineering of Integrated Process Modelling Techniques. Integrated process modelling techniques such as UML and ARIS form the conceptual platform for many management and IT projects. Though most IS development tools contain these techniques, anecdotal evidence indicates many shortcomings. This project uses a well-established theory developed in philosophy and applied in information systems domains for the evaluation of these techniques. The expected outcomes are evaluations of ARIS and UML. Thus, this project contributes to the development of two of the most popular modelling techniques. Based on the theory used and the results of an international empirical study, suggestions for the further development of these techniques will be derived.Read moreRead less
Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinic ....Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinical trials for possible effective treatments of neurological diseases such as motor neurone disease to be conducted with an objective measurement of disease progression. Read moreRead less
Integrating Database Technologies and Visual Analysis in Bioinformatics for Genome Data. Solving modern biological problems, especially those involving genome data, requires advanced computational and analytical methods. The huge quantities of data and escalating demands of modern biological research increasingly require the sophistication and power of object-relational database tools. Key techniques include relational data management, pattern recognition, data mining and visualization of biolog ....Integrating Database Technologies and Visual Analysis in Bioinformatics for Genome Data. Solving modern biological problems, especially those involving genome data, requires advanced computational and analytical methods. The huge quantities of data and escalating demands of modern biological research increasingly require the sophistication and power of object-relational database tools. Key techniques include relational data management, pattern recognition, data mining and visualization of biological data. In this project we will develop efficient methodologies and data structures for gathering high-quality approximations of full genomic information, and will use these innovations as the foundation to develop novel, practical tools for clustering and visualization in genomic data mining and database management.
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Spotting Near-duplicate Sequences from Online Databases, Streams and Communities. This project studies a very important problem which has significant research and economy value. Advances in this project will reshape the landscape of media, commercial and legal service industries. Success of this project will not only establish us as an internationally leading research group but also bring significant economic and social benefits. Australia organizations with media assets will be benefited by sav ....Spotting Near-duplicate Sequences from Online Databases, Streams and Communities. This project studies a very important problem which has significant research and economy value. Advances in this project will reshape the landscape of media, commercial and legal service industries. Success of this project will not only establish us as an internationally leading research group but also bring significant economic and social benefits. Australia organizations with media assets will be benefited by saving enormous cost, improving service quality, protecting their intelligence properties, etc. It will also advance Australia's intellectual leadership in copyright compliance and benefit commercialization of research results.Read moreRead less
The Development of High Strength Aluminium and Magnesium Alloys Using "Edge-to-edge" Matching Model. The theoretical, crystallographic "edge-to-edge" matching model for diffusion-controlled phase transformations will be applied to the practical development of improved industrial aluminium and magnesium alloys with assistance of computer simulations. The model will be used to enhance the precipitation hardening response and to identify more effective grain refiners in these light alloys. The aim ....The Development of High Strength Aluminium and Magnesium Alloys Using "Edge-to-edge" Matching Model. The theoretical, crystallographic "edge-to-edge" matching model for diffusion-controlled phase transformations will be applied to the practical development of improved industrial aluminium and magnesium alloys with assistance of computer simulations. The model will be used to enhance the precipitation hardening response and to identify more effective grain refiners in these light alloys. The aims will be the development of one high strength aluminium alloy with good ductility and one high strength magnesium alloy with good creep resistance at elevated temperatures. A computer program that will help to identify the most effective grain refiners for specific light alloys will also be produced.Read moreRead less
High Resolution EPR Spectroscopy - A Tool for Determining Electronic and Geometric Structure of Metalloenzymes. High resolution orientation selective pulsed EPR and END(T)OR in conjunction with computer simulation (XSophe) and computational chemistry will allow the determination of the electronic and geometric structure (distance and orientation of nuclei surrounding the metal ion(s)) of multiple redox centres in DMSOR, DorC and DMSDH to be determined. In addition pulsed ELDOR in conjunction wi ....High Resolution EPR Spectroscopy - A Tool for Determining Electronic and Geometric Structure of Metalloenzymes. High resolution orientation selective pulsed EPR and END(T)OR in conjunction with computer simulation (XSophe) and computational chemistry will allow the determination of the electronic and geometric structure (distance and orientation of nuclei surrounding the metal ion(s)) of multiple redox centres in DMSOR, DorC and DMSDH to be determined. In addition pulsed ELDOR in conjunction with molecular modelling will enable the mapping (distance and orientation) of redox centres in complex multicentered metalloproteins (DMSDH and DorC) and in protein-protein complexes (DMSOR-DorC) providing information on the pathway of electron transfer and hence the role of the pyranopterins.Read moreRead less
Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most ....Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most industries in Australia. More specifically, it is to be applied here to the diagnosis and prognosis of ovarian cancer. This cross-disciplinary project will strengthen Australian researchers' capacity and capability of participating in cutting-edge DNA microarray research.
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