Towards the prime power conjecture. This project attacks a famous and long standing conjecture in pure mathematics that has important ramifications in many applied areas. The project aims to determine when it is possible to produce more efficient codes for electronic communication and statistically balanced designs for experiments in areas as diverse as agriculture and psychology.
A new approach to compressed sensing. Compressed sensing is an exciting new paradigm promising vastly improved signal sampling and reconstruction in a wide variety of applications including digital cameras, mobile phones and MRI machines. This project will explore a newly discovered approach to compressed sensing which uses mathematical arrays known as hash families.
Matchings in Combinatorial Structures. The theory of matching in graphs concerns the problem of pairing up objects, subject to constraints on which objects may be paired. It is a well-developed theory that is not only of tremendous mathematical importance, but is also widely applied to efficiently deal with allocation and scheduling problems. Much less is known, however, about the equally important but harder problem of dividing objects into collections of three or more. This project aims to add ....Matchings in Combinatorial Structures. The theory of matching in graphs concerns the problem of pairing up objects, subject to constraints on which objects may be paired. It is a well-developed theory that is not only of tremendous mathematical importance, but is also widely applied to efficiently deal with allocation and scheduling problems. Much less is known, however, about the equally important but harder problem of dividing objects into collections of three or more. This project aims to address this deficiency by developing the theory of matching in important combinatorial objects. The problems it expects to solve are of great significance in their own right, and when considered together may help to lay a foundation for a more general theory of matching.Read moreRead less
Fractional decomposition of graphs and the Nash-Williams conjecture. Nash-Williams' conjecture is a famous unsolved problem about decomposing graphs (abstract networks). Breakthrough results achieved in recent years have shown that the conjecture, along with other major graph decomposition problems, could be solved if only more were known about fractional decomposition. This project aims to clear this bottleneck to progress by dramatically expanding the state of knowledge on fractional decomposi ....Fractional decomposition of graphs and the Nash-Williams conjecture. Nash-Williams' conjecture is a famous unsolved problem about decomposing graphs (abstract networks). Breakthrough results achieved in recent years have shown that the conjecture, along with other major graph decomposition problems, could be solved if only more were known about fractional decomposition. This project aims to clear this bottleneck to progress by dramatically expanding the state of knowledge on fractional decomposition. Expected outcomes include major progress on Nash-Williams' conjecture and related graph decomposition problems. This should enhance Australia's research reputation in pure mathematics and provide benefits in downstream applications areas including statistics, data transmission, and fibre-optic networks.Read moreRead less
Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identi ....Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identifying RNA molecules that contribute to quantitative phenotypes including susceptibility to disease. As such, it will directly benefit fundamental science via the discovery and classification of new molecules. Indirectly, it will lead to breakthroughs in biology, and consequently to major medical and pharmaceutical advances in the diagnosis and treatment of genetic disease.Read moreRead less
Synchromodal container logistics for Australia. Synchromodal container logistics for Australia. This project aims to develop advanced mathematical optimization models and algorithms to create multi-modal logistics approaches for container movements in and out of Australia’s busy ports. The increasingly congested capital cities of Sydney, Brisbane and Melbourne need to find new ways of moving an increasing volume of containerized freight. Moving from trucks to rail is expected to reduce pollution ....Synchromodal container logistics for Australia. Synchromodal container logistics for Australia. This project aims to develop advanced mathematical optimization models and algorithms to create multi-modal logistics approaches for container movements in and out of Australia’s busy ports. The increasingly congested capital cities of Sydney, Brisbane and Melbourne need to find new ways of moving an increasing volume of containerized freight. Moving from trucks to rail is expected to reduce pollution and road congestion, but is only possible if highly efficient modes of operation can be developed. Research into system design and operational scheduling is expected to achieve the required efficiency for multi-modal logistics that will reduce air pollution and road congestion.Read moreRead less
Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international effo ....Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international efforts in this area, via the development of statistical methods for segmenting genomes, classification of those segments, and study of the resulting classes. In the long term, enhanced understanding of eukaryotic cells will lead to breakthroughs in biology, and to medical, pharmaceutical, agricultural and scientific advances.Read moreRead less
Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowle ....Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowledge of normal and abnormal developmental processes, especially in embryonic growth. Understanding these processes should lead to prediction and treatment of congenital disorders and contribute to a healthy start to life.Read moreRead less
Unpacking the immune system with applied mathematics. This project aims to model immune interactions across cells and structures spanning scales of nanometres to millimetres. It expects to develop innovative mathematical insights, improve our understanding of immunology, and consolidate collaborations with top American and European laboratories and groups. Expected outcomes include cutting-edge techniques for multiscale biological modelling and improved prediction and analysis of immune dynami ....Unpacking the immune system with applied mathematics. This project aims to model immune interactions across cells and structures spanning scales of nanometres to millimetres. It expects to develop innovative mathematical insights, improve our understanding of immunology, and consolidate collaborations with top American and European laboratories and groups. Expected outcomes include cutting-edge techniques for multiscale biological modelling and improved prediction and analysis of immune dynamics. The project should provide benefits to industries where highly organised behaviours are important, for example those interested in robot swarming, optimal transportation, and epidemic management. It should also benefit Australian students and researchers with novel overseas training opportunities.Read moreRead less