Innovative mathematical modelling to determine incorporation of gene therapy in different cell lineages; Human Immunodeficiency Virus (HIV) as a model setting. Gene therapy is a promising therapeutic that is being developed to address genetic diseases and viral infections such as Human Immunodeficiency Virus (HIV). This project will produce mathematical models of how gene therapy delivered to one type of cell can differentiate into the desired end target and impact disease.
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
Bodies in space. By investigating how a change in shape of the human body can produce a change in spatial orientation, the project will bring a fundamental advance of knowledge in the intersection of applied mathematics, sports science and mechanical engineering. These knowledge advances will lead to a novel theory regarding the control of the aerial dynamics of athletes, specifically springboard and platform divers. When applied in collaboration with world class Australian athletes, this theory ....Bodies in space. By investigating how a change in shape of the human body can produce a change in spatial orientation, the project will bring a fundamental advance of knowledge in the intersection of applied mathematics, sports science and mechanical engineering. These knowledge advances will lead to a novel theory regarding the control of the aerial dynamics of athletes, specifically springboard and platform divers. When applied in collaboration with world class Australian athletes, this theory will result in innovative platform and springboard diving techniques and improved performance. The reach of new insights generated by this work extends to many other fields, including robotics, spacecraft dynamics and nano technology.Read moreRead less
Optimising experimental design for robust product development: a case study for high-efficiency energy generation. This project tackles key mathematical challenges to provide a powerful new methodology and tool for optimal product design, making smarter use of limited information, minimising costly trials, shortening the product cycle, and boosting the competitiveness of both the Australian manufacturing and alternative energy production industries.
A Just Climate Transition. Australia's climate transition will have to drastically cut our national emissions. Yet our transition also needs to be fair. This project will develop a social justice framework for the implementation of a zero net emissions climate transition for rural Victoria. This will be the first comprehensive incorporation of social justice framework with detailed mitigation strategies for rural Australia. The research will combine insights from leading Australian and internat ....A Just Climate Transition. Australia's climate transition will have to drastically cut our national emissions. Yet our transition also needs to be fair. This project will develop a social justice framework for the implementation of a zero net emissions climate transition for rural Victoria. This will be the first comprehensive incorporation of social justice framework with detailed mitigation strategies for rural Australia. The research will combine insights from leading Australian and international energy groups and current research to produce valuable inputs into a national just transitions strategy and provide benefits to Industry partners and the sector. The project will significantly contribute to our understanding of a just climate transition.Read moreRead less
Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It w ....Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It will bring the armoury of policy analysis instruments available to these countries up to the standard now enjoyed by the developed world. Indonesia, on the brink of major pension reform, will be used as a test bed. Data sets will be developed to allow the model structure to be applied to other emerging economies in Asia. Read moreRead less
Providing the Mathematical Foundation for an Innovative Australia within Reform Based Learning Environments. The focus of this project is the pedagogical change that The Review of Teaching and Teacher Education indicates must take place in order to lay the quantitative foundations for advancing innovation, science, technology, and mathematics, while satisfying the requirements of a reform-based learning environment. Professional learning directed at teachers' pedagogical content knowledge and be ....Providing the Mathematical Foundation for an Innovative Australia within Reform Based Learning Environments. The focus of this project is the pedagogical change that The Review of Teaching and Teacher Education indicates must take place in order to lay the quantitative foundations for advancing innovation, science, technology, and mathematics, while satisfying the requirements of a reform-based learning environment. Professional learning directed at teachers' pedagogical content knowledge and belief structures with respect to mathematics within an environment of curricular change, will be evaluated in evidence-based terms related to teacher change and student outcomes. Significance includes the context, the middle school years in rural district schools, and the influence of technology on pedagogy.Read moreRead less
Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement i ....Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement income and public pension receipt. The project will develop a new tax records-based dataset to facilitate future research on tax and welfare systems.Read moreRead less
Insecure Work and the Mental Health of Workers and their Families. This project aims to explore the relationship between insecure work and mental health by applying advanced econometric methods to large survey and administrative datasets, and newly collected survey data. This project expects to provide causal policy-relevant estimates of how insecure work is affecting the wellbeing of workers and their families, and for whom the effects are most harmful. It also expects to inform on how poor men ....Insecure Work and the Mental Health of Workers and their Families. This project aims to explore the relationship between insecure work and mental health by applying advanced econometric methods to large survey and administrative datasets, and newly collected survey data. This project expects to provide causal policy-relevant estimates of how insecure work is affecting the wellbeing of workers and their families, and for whom the effects are most harmful. It also expects to inform on how poor mental health influences the types of jobs that people enter into. This should provide significant benefits, including evidence needed to improve existing workplace and employment programs, and evidence ensuring that assistance is efficiently targeted to those workers and industries with the greatest need.Read moreRead less