Clarifying The Pathogenic Role Of Arousal-hyperventilation In Obstructive And Central Sleep Apnoea: Testing Fundamental Pathophysiological Mechanisms And A Strategic New Treatment
Funder
National Health and Medical Research Council
Funding Amount
$414,717.00
Summary
This project is designed to understand the mechanisms underpinning much more stable breathing during deep sleep in obstructive sleep apnoea (OSA). A newly developed analytical technique will be used to examine breathing effort changes across sleep, and interactions with respiratory-induced awakenings in OSA patients. In addition, a new treatment designed to stabilise breathing will be tested and refined towards a new treatment option for OSA and for central sleep apnoea.
The Role Of Arousal And Respiratory Control Factors In The Pathogenesis Of Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$567,924.00
Summary
Sleep apnoea (OSA) is a very common breathing disorder in sleep characterized by repetitive closure of the collapsible portion of the throat with serious effects on sleep quality and health. Basic causes of OSA are still largely unknown. We will investigate waking responses to breathing load and related respiratory control factors that we believe may be fundamental causes of OSA, and potentially explain many features of OSA including worsening in light sleep and with increasing age.
The Role Of Arousal And Diaphragm Displacement In The Pathogenesis Of Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$410,875.00
Summary
Obstructive sleep apnea (OSA) affects 4% of men and causes excessive daytime sleepiness leading to increased accidents, high blood pressure and premature cardiovascular disease e.g. heart attacks and strokes. OSA is characterized by repetitive obstructions of the floppy portion of the throat during sleep with adverse effects on oxygen levels and sleep quality. OSA is strongly associated with obesity and is 2-3 times more common in men than women. How obesity and male gender predispose to OSA is ....Obstructive sleep apnea (OSA) affects 4% of men and causes excessive daytime sleepiness leading to increased accidents, high blood pressure and premature cardiovascular disease e.g. heart attacks and strokes. OSA is characterized by repetitive obstructions of the floppy portion of the throat during sleep with adverse effects on oxygen levels and sleep quality. OSA is strongly associated with obesity and is 2-3 times more common in men than women. How obesity and male gender predispose to OSA is not known. We will investigate two factors that we believe are most likely involved in causing and explaining this gender difference in OSA. We will examine if breathing responses with brief awakening are sufficient to promote OSA patterns of breathing in snorers and if they are greater in male than female OSA patients. We have already shown that healthy men have greater breathing response to arousal compared to women. These brief arousals occur hundreds of times a night in OSA patients, and over-breathing on arousal may increase the probability of upper airway obstruction on falling back to sleep. We will also investigate why even healthy men show greater breathing responses compared to women. Men tend to accumulate fat centrally, particularly in the abdomen, whereas in women fat tends to be distributed more to the hips and thighs. This could be very important in OSA because downward pull exerted on the upper airway by the diaphragm is likely to be reduced in people with more abdominal obesity. This mechanisms has not yet been studied in humans. We will therefore investigate if increased forces placed on the diaphragm during sleep make the upper airway more prone to collapse. We will also investigate these effects during sleep onset, when there may well be important changes in diaphragm position as muscles relax.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100328
Funder
Australian Research Council
Funding Amount
$374,000.00
Summary
Minimising transaction costs in Murray-Darling Basin water reform. Transaction costs provide social, economic, environmental and political barriers to the effectiveness of water reallocation policy in Australia. These costs are often difficult to quantify, but potentially are subject to measurement. This project aims to develop a comprehensive transaction cost framework for the Murray-Darling Basin that can be used to capture and measure transaction costs related to water policy. Further, the sc ....Minimising transaction costs in Murray-Darling Basin water reform. Transaction costs provide social, economic, environmental and political barriers to the effectiveness of water reallocation policy in Australia. These costs are often difficult to quantify, but potentially are subject to measurement. This project aims to develop a comprehensive transaction cost framework for the Murray-Darling Basin that can be used to capture and measure transaction costs related to water policy. Further, the scope of the cost measurement will involve a variety of data collection approaches. Outcomes include better water policy and management from arrangements that will span the divide between the Basin Plan and its implementation.Read moreRead less
Investigating the Indirect Effects of Child-Targeted Food Promotion on Children's Diets. Obesity is forecast to cost the Australian community more than $58 billion in 2008. The prevention and reduction of obesity thus has the potential to create significant savings in terms of obesity-related treatment costs and impairments. Children have been identified as a population requiring particular attention in efforts to combat obesity. The proposed study will provide an enhanced understanding of the r ....Investigating the Indirect Effects of Child-Targeted Food Promotion on Children's Diets. Obesity is forecast to cost the Australian community more than $58 billion in 2008. The prevention and reduction of obesity thus has the potential to create significant savings in terms of obesity-related treatment costs and impairments. Children have been identified as a population requiring particular attention in efforts to combat obesity. The proposed study will provide an enhanced understanding of the role that food promotion plays in sub-optimal food choices made by children and their parents. The results of the study will be translated into specific public policy recommendations to assist governments and health agencies in determining appropriate courses of action to promote healthy diets among children and their families.Read moreRead less
Behind the scenes: diversity management paradigm shifts and sticking points. Many Australian organisations miss out on the potential benefits of workforce diversity because they do not manage diversity effectively. This project will investigate how organisations can initiate and direct change processes to manage diversity more effectively, and as a result, experience higher productivity and employee engagement.
The impact of institutional pressure on the management of organisational gender diversity. Women’s low representation in senior management and boards led to the Australian Securities Exchange (ASX) requiring listed companies to report on gender diversity. This project examines if women’s representation is changing in response to the ASX requirements and identifies organisational strategies for achieving sustainable gender diversity.
Breaking free: How organisations become front runners in gender diversity. This project aims to understand why a few exceptional organisations make substantive progress toward gender equality when so many of their competitors fail. Gender equality has social and economic value but despite decades of equal opportunity legislation and investment in gender initiatives, gender inequality persists in organisations all around the world. The project’s case study methodology examines how gender diversi ....Breaking free: How organisations become front runners in gender diversity. This project aims to understand why a few exceptional organisations make substantive progress toward gender equality when so many of their competitors fail. Gender equality has social and economic value but despite decades of equal opportunity legislation and investment in gender initiatives, gender inequality persists in organisations all around the world. The project’s case study methodology examines how gender diversity front runners align their diversity policies and practices with their internal identity and external reputation to produce substantive change. Understanding these dynamic processes will identify strategies that laggard organisations can adopt to make greater progress toward gender equality.Read moreRead less
Can attentional re-training reduce food cravings and consumption? This project aims to determine the impact of a procedure involving the re-training of attention to food cues on food cravings and food intake. Results will advance our understanding of food cravings and contribute to interventions aimed at curbing unwanted cravings and (over) consumption.
Critical windows: understanding changes in eating and physical activity over the transition from secondary school to young adulthood. This project will explain changes in eating, physical activity and sedentary behaviour during the critical period of transition from secondary school to young adulthood. It will provide important information on how we can assist adolescents to maintain a healthy lifestyle over a time characterised by several major life changes.