Vascular And Neurogenic Determinants Of Hypertension In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$508,142.00
Summary
You are as old as your arteries, and people with kidney disease have arteries that age fast. They also have overactive sympathetic nerves, and it is not clear if the blood vessels or nerves are responsible for the high blood pressure that puts strain on the heart and other organs of these patients. We will use an animal model to determine if therapy for hypertension reduces the stiffness of blood vessels or elevated nerve activity. Our results will enable better treatments for kidney failure.
Discovery Early Career Researcher Award - Grant ID: DE120102645
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The cause of the poleward shift of Earth's storm tracks and jet streams. Why do global climate models shift the atmospheric storm tracks and jet streams poleward in simulations of future climate? This project will determine the underlying causes of the most important circulation change that is projected to occur with increasing greenhouse gases, and will allow much more accurate regional climate projections.
Local climate changes caused by large bushfire burnt areas. This project aims to quantify the impact on local climate produced by large burnt areas after extreme bushfires. This project expects to generate new knowledge on these previously unexplored fire-scar induced changes to local climate. It will extend an innovative approach that combines satellite based earth observation with very high resolution regional climate modelling to quantify the impacts on land-atmosphere feedbacks and local cli ....Local climate changes caused by large bushfire burnt areas. This project aims to quantify the impact on local climate produced by large burnt areas after extreme bushfires. This project expects to generate new knowledge on these previously unexplored fire-scar induced changes to local climate. It will extend an innovative approach that combines satellite based earth observation with very high resolution regional climate modelling to quantify the impacts on land-atmosphere feedbacks and local climate. Expected outcomes of this project include enhanced methods to quantify local climate changes after extreme fires and their effect on vegetation recovery. This should provide significant benefits to the planning for, and management of, vegetation recovery after extreme fires.Read moreRead less
Identification Of Heterogeneity In Vasodilator Function In Human And Rat Resistance Vessels: Potential Drug Targets?
Funder
National Health and Medical Research Council
Funding Amount
$595,330.00
Summary
The balance between the ways that blood vessels decrease in size (constrict) and increase in size (dilate) determine how blood vessels normally function. There are many differences in the ways that blood vessels control this balance in different parts of the body. Such differences are altered in vascular diseases, such as hypertension and diabetes, which are prevalent in obesity, such that constriction generally outweighs dilation. However, what these differences are and how they occur are not w ....The balance between the ways that blood vessels decrease in size (constrict) and increase in size (dilate) determine how blood vessels normally function. There are many differences in the ways that blood vessels control this balance in different parts of the body. Such differences are altered in vascular diseases, such as hypertension and diabetes, which are prevalent in obesity, such that constriction generally outweighs dilation. However, what these differences are and how they occur are not well understood. While current drugs for treating vascular disease either reduce vessel constriction or increase dilation, they are not specific for individual arteries; a situation that would allow us to control vascular diseases in a very specific manner. Recently, we have described differences between the ways that individual vessels are controlled. These changes relate to differences in the way that different vessels dilate. AIMS - To further understand normal blood vessel function and the changes that occur in blood vessels in cardiovascular disease, with a focus on the ways that blood vessels dilate in normal states and in obesity-related diseases, such as in hypertension and diabetes. - The eventual aim is to identify the specific ways that arteries function, so that artery-specific drug targets can be identified to treat disease-related changes in cardiovascular disease in a very specific manner. EXPECTED OUTCOMES This project will contribute to understanding blood vessel function in health and disease. The expected eventual outcome is the identification of the mechanisms that underlie the function of different arteries in different parts of the body, so that specific individual vessel function can be targeted to treat vascular disease. Additionally, this work will also verify the relevance of the diet-induced obesity animal model, in terms of the characteristics and causes of human obesity and related cardiovascular disease.Read moreRead less
Role of modulating water wave groups in enhancing air-water fluxes. This project aims to investigate the importance of the group structure and breaking of wind-generated waves of various scales in the air-water exchange of mass, momentum and energy. This project expects to generate new understanding in the area of air-water exchanges using an innovative approach based on direct numerical simulation of wind over unsteady water wave groups for a wide range of wind speed and wave steepness conditi ....Role of modulating water wave groups in enhancing air-water fluxes. This project aims to investigate the importance of the group structure and breaking of wind-generated waves of various scales in the air-water exchange of mass, momentum and energy. This project expects to generate new understanding in the area of air-water exchanges using an innovative approach based on direct numerical simulation of wind over unsteady water wave groups for a wide range of wind speed and wave steepness conditions.
Expected outcomes of this project include generating fundamental knowledge of the unresolved physics and new parameterisations for air-water exchange rates. This will deliver more accurate and more comprehensive forecast models for weather, inland and ocean waterways, and numerous industrial processes.Read moreRead less
The dynamics of turbulent entrainment in sheared convective boundary layers. This project aims to develop general laws to enable the accurate prediction of boundary layer entrainment processes. This will be significant in a wide range of environmental and engineering applications. In particular, the current lack of understanding of this area is a major source of uncertainty in the latest generation of global climate models.
Understanding extreme wind gusts and associated risks in NSW. Wind gusts are rare bursts of high wind, often associated with thunderstorm outflows. They can do significant structural damage, and their rarity and small scale make prediction and risk assessment difficult. This proposal seeks to better understand and predict wind gusts and their impacts to aid in planning. The project aims to use past observations, modelling, and basic theory to show what conditions lead to wind gusts and how like ....Understanding extreme wind gusts and associated risks in NSW. Wind gusts are rare bursts of high wind, often associated with thunderstorm outflows. They can do significant structural damage, and their rarity and small scale make prediction and risk assessment difficult. This proposal seeks to better understand and predict wind gusts and their impacts to aid in planning. The project aims to use past observations, modelling, and basic theory to show what conditions lead to wind gusts and how likely they are to exceed key thresholds. It targets important scientific and practical issues such as the joint occurrence of gusts and high rainfall, role of gusts in contributing to dust and other airborne pollutants, impacts of gusts on subsequent storm activity, and gusts in a warming climate.Read moreRead less
Novel techniques for interpreting atmospheric variability and its drivers. This project aims to improve the understanding of the causes of variability in atmospheric greenhouse gases, leading to better knowledge of how such processes will evolve in a changing climate. The project expects to use new measurement techniques to gain information about the spatial and temporal variability of atmospheric greenhouse gases. With the use of regional and global scale models, the measurements will be used t ....Novel techniques for interpreting atmospheric variability and its drivers. This project aims to improve the understanding of the causes of variability in atmospheric greenhouse gases, leading to better knowledge of how such processes will evolve in a changing climate. The project expects to use new measurement techniques to gain information about the spatial and temporal variability of atmospheric greenhouse gases. With the use of regional and global scale models, the measurements will be used to understand greenhouse gas fluxes and provide independent verification of current estimates. Expected outcomes include improved methods for verifying greenhouse gas emissions, which will contribute to improved emissions inventories and accounting promised under international agreements.Read moreRead less
Atmospheric Photothermal Oxidation as a New Reaction in the Atmosphere. Atmospheric models provide crucial advice on the current and future impacts of human activity on the atmosphere. This project hypothesizes the presence of a new class of chemical reactions that are unknown in atmospheric science and therefore missing from the best existing models. The reactions require both sunlight and air, and they behave differently to all other types of atmospheric reactions. This project aims to charact ....Atmospheric Photothermal Oxidation as a New Reaction in the Atmosphere. Atmospheric models provide crucial advice on the current and future impacts of human activity on the atmosphere. This project hypothesizes the presence of a new class of chemical reactions that are unknown in atmospheric science and therefore missing from the best existing models. The reactions require both sunlight and air, and they behave differently to all other types of atmospheric reactions. This project aims to characterise these reactions in the lab, understand them with theory, and quantify their global impact through modelling. Expected benefits include new understanding of atmospheric chemistry, more accurate model predictions, and—as a result—better strategies for managing the impacts of human activity on the environment.Read moreRead less
ARC Centre of Excellence for Climate Extremes. This Centre aims to transform understanding of past and present climate extremes and revolutionise Australia’s capability to predict them into the future. Climate extremes cost Australia up to $4 billion a year and will intensify over coming decades. This Centre’s blue-sky research will discover processes that explain the behaviour of present and future climate extremes. It will use its researchers, data, modelling, collaboration, graduate programme ....ARC Centre of Excellence for Climate Extremes. This Centre aims to transform understanding of past and present climate extremes and revolutionise Australia’s capability to predict them into the future. Climate extremes cost Australia up to $4 billion a year and will intensify over coming decades. This Centre’s blue-sky research will discover processes that explain the behaviour of present and future climate extremes. It will use its researchers, data, modelling, collaboration, graduate programme and early career researcher mentoring to transform Australia’s capacity to predict climate extremes. This research is expected to make Australia more resilient to climate extremes and minimise risks from climate extremes to the Australian environment, society and economy.Read moreRead less