Selective Isolation And In Vivo Properties Of Dopamine Neurons Generated From Embryonic Stem Cells.
Funder
National Health and Medical Research Council
Funding Amount
$505,389.00
Summary
This research aims to develop a procedure that allows for the safe and effective use of stem cells as a therapy for Parkinson’s disease. It is based on the concept that new dopamine neurons, generated from stem cells, can be implanted into the brain of the patients in order to replace those lost to the disease, thereby improving motor function.
National Centre Of Research Excellence To Improve Management Of Peripheral Arterial Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,618,637.00
Summary
Approximately 15% of adults have blockages or weakness of major arteries in the periphery, associated with impaired quality of life and a high mortality. Significant management deficiencies for these problems include limited diagnostic, prognostic and treatment options, as well as poor adoption of evidence based practice. The proposed national centre will bring together a group of experts in the field to instigate a number of initiatives to improve patient management.
Innovative Technology for At-Scene Forensic Analysis using Microfluidics and Chemiluminescence. The major outcome of this project will be innovative reagents and strategies optimised for the detection of priority analytes such as drugs, explosives and chemical warfare agents. These will utilise a new technology platform based upon laboratory on a chip/microfluidics to enable the development of analytical methodologies suitable for use at crime scenes.This programme of research falls within a Nat ....Innovative Technology for At-Scene Forensic Analysis using Microfluidics and Chemiluminescence. The major outcome of this project will be innovative reagents and strategies optimised for the detection of priority analytes such as drugs, explosives and chemical warfare agents. These will utilise a new technology platform based upon laboratory on a chip/microfluidics to enable the development of analytical methodologies suitable for use at crime scenes.This programme of research falls within a National Research Priority namely 'Protecting Australia from terrorism and crime'. Through our current forensic science research collaboration the outcomes will build significantly on Australia's existing strengths in rapid detection using new analytical technologies.Read moreRead less
The dynamics of subtropical anticyclones and the connection to drought, heatwaves and bushfires in southern Australia. The aim of the project is to understand the dynamics of anticyclones (high pressure systems) in the region of southern Australia. The study of anticyclones in the region is important because of their very strong connection to rainfall in the winter, and heatwaves and bushfires in the summer, and because so little work has been done on understanding what is the defining feature o ....The dynamics of subtropical anticyclones and the connection to drought, heatwaves and bushfires in southern Australia. The aim of the project is to understand the dynamics of anticyclones (high pressure systems) in the region of southern Australia. The study of anticyclones in the region is important because of their very strong connection to rainfall in the winter, and heatwaves and bushfires in the summer, and because so little work has been done on understanding what is the defining feature of the climate of southern Australia. Understanding what controls the location and strength of these features will go a long way to explaining how the climate of southern Australia will change in a warmer world.Read moreRead less
Suppression Of NADPH Oxidase-derived Oxidative Stress By Anti-sense Probes And HDL In Human Vascular Endothelium
Funder
National Health and Medical Research Council
Funding Amount
$455,250.00
Summary
In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) develo ....In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) developed in our laboratory, which block a particular gene causing oxidative stress, we will determine whether this gene is responsible for the formation of oxyradicals in human and mouse cells grown in culture. In addition, we will explore whether this gene is turned on by factors known to be involved in CHD. Finally, we will also investigate whether the good cholesterol known as HDL can act to prevent oxidative stress in human cells, as we discovered it appears to do in living arteries in vivo. If we find it has the same protective effect in endothelium, we will determine how it does this, and which component proteins of the HDL particle are important. This might suggest new treatments to prevent acute events leading to heart attack and stroke, and possibly new applications where damage appears to result from acute oxidative stress, such as in the brain soon after a stroke has occurred. We also have a plan to develop antisense drugs that will target the important gene specifically in the affected endothelium. In addition, we have other specific new drugs that will block this system in arteries. Simultaneously we will be testing the role of this gene in mouse and rabbit models of artery disease, for both our types of drugs might provide valuable new therapeutic agents to target the underlying cause of CHD and not just its symptoms as current drugs do.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100866
Funder
Australian Research Council
Funding Amount
$325,000.00
Summary
Intense thunderstorms in the tropics and subtropics under global warming. This project aims to determine how the frequency of intense tropical and subtropical thunderstorms will change as a result of future global warming. Climate models project that the energy available to such storms will increase in the future, but the reasons for this increase in available energy, and the implications for thunderstorm activity, remain uncertain. Using observations and high-resolution models, the project expe ....Intense thunderstorms in the tropics and subtropics under global warming. This project aims to determine how the frequency of intense tropical and subtropical thunderstorms will change as a result of future global warming. Climate models project that the energy available to such storms will increase in the future, but the reasons for this increase in available energy, and the implications for thunderstorm activity, remain uncertain. Using observations and high-resolution models, the project expects to generate new knowledge of the mechanisms driving changes in intense thunderstorm activity under climate change, and to provide more accurate projections of the frequency of intense thunderstorms in a warmer climate. This project should deliver benefits to sectors of the economy such as agriculture and transportation, which are significantly exposed to such hazards.Read moreRead less
Links between bushfires in Victoria and floods in Queensland. This project will investigate connections between bushfires in Victoria and floods in Queensland under the framework that atmospheric blocking can be thought of as a common link. High resolution runs using the Intergovernmental Panel on Climate Change future projections of the energetics of high impact weather will improve climate forecasts in sensitive coastal areas of the country.
The Southern Ocean boundary layer: winds, turbulence, sea spray and clouds. Both satellite products and climate models have large biases in the energy and water budgets over the Southern Ocean (SO). This is a direct consequence of a poor understanding of the structure and dynamics of the SO atmospheric boundary layer, which has arisen from an inability to make the necessary observations in this harsh environment. Due to the availability of new Australian research infrastructure, large steps forw ....The Southern Ocean boundary layer: winds, turbulence, sea spray and clouds. Both satellite products and climate models have large biases in the energy and water budgets over the Southern Ocean (SO). This is a direct consequence of a poor understanding of the structure and dynamics of the SO atmospheric boundary layer, which has arisen from an inability to make the necessary observations in this harsh environment. Due to the availability of new Australian research infrastructure, large steps forward are now possible with modest investment. This project will conduct and combine observations from the recently acquired marine vessel, RV Investigator, and the collocated airborne and surface observations to understand the structure and evolution of the unique, pristine SO boundary layer and to evaluate satellites and climate models.Read moreRead less
Mitochondrial Damage Following Fetal Hypoxia Or Birth Asphyxia: Using Creatine To Preserve Mitochondrial Function
Funder
National Health and Medical Research Council
Funding Amount
$838,726.00
Summary
There is a need for a therapy that can be given before a mother gives birth to protect the baby should ‘oxygen starvation’ threaten the baby’s brain and other organs such as the heart, kidney, lungs, and the ability to breathe properly. We are suggesting that an increased intake of creatine is a very effective treatment against this threat, and its proven safety and ease of use recommends it for wide application, particularly in countries where the access to medical resources is poor.
GBR as a significant source of climatically relevant aerosol particles. Every cloud drop is formed from a microscopic aerosol particle, known as a cloud condensation nuclei (CCN). In unpolluted environments the CCN particles originate from biogenic sources. Determining the magnitude and driving factors of biogenic aerosol production in different ecosystems is crucial to the development and improvement of climate models. This project aims to determine the mechanisms of new particle production fro ....GBR as a significant source of climatically relevant aerosol particles. Every cloud drop is formed from a microscopic aerosol particle, known as a cloud condensation nuclei (CCN). In unpolluted environments the CCN particles originate from biogenic sources. Determining the magnitude and driving factors of biogenic aerosol production in different ecosystems is crucial to the development and improvement of climate models. This project aims to determine the mechanisms of new particle production from one of the biggest ecosystems in Australia, the Great Barrier Reef. It is expected that the project will establish whether marine aerosol along the Queensland coast is coral-derived and show that this aerosol can affect the CCN concentration and therefore cloud formation and the hydrological cycle.Read moreRead less