Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
Strabismus is the pathological misalignment of the eyes associated with loss of binocular vision and is one of the most common human ophthalmological disorders. Patients with comitant strabismus have full eye movements, whereas patients with incomitant strabismus have limited eye movements, which causes the angle of strabismus to vary with gaze direction. This project aims to define genetic contributors to comitant congenital strabismus.
Translating Genetic Determinants Of Glaucoma Into Better Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$9,466,000.00
Summary
Glaucoma is the leading cause of irreversible blindness worldwide. By 2020, it will affect 80 million people, and in Australia over the next decade, the overall cost of glaucoma will reach $4.3 billion per annum. This Program will use genetic advances to personalise treatment. Blindness will be prevented in individuals at highest risk, new ways to treat patients will be developed, and better outcomes for patients will result from less treatment and monitoring of low risk cases.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Young Adult Myopia: Genetic And Environmental Associations
Funder
National Health and Medical Research Council
Funding Amount
$809,271.00
Summary
Myopia affects 80% of school leavers in the cities of East Asia, 45% of Asian Australian school leavers and is probably on the rise in European Australian adolescents. Increased levels of education and lack of time outdoors are known to increase the risk of myopia. We will examine 2,000 young adults to find the genes that interact with these risk factors. In addition to confirming when these risk factors are most important, identifying molecular pathways opens the avenue of new treatments.
Effective Fuzzy Systems for Complex Structured Data Using Fuzzy Signatures. We are developing systematic, heuristic and mathematical techniques to produce effective fuzzy systems for complex structured data. Many or most real world problems have data which has interdependent sub-components depending on the context (eg only female patients need be tested for pregnancy), and often has missing components. Our techniques use fuzzy signatures to extend simple fuzzy systems to deal with data with such ....Effective Fuzzy Systems for Complex Structured Data Using Fuzzy Signatures. We are developing systematic, heuristic and mathematical techniques to produce effective fuzzy systems for complex structured data. Many or most real world problems have data which has interdependent sub-components depending on the context (eg only female patients need be tested for pregnancy), and often has missing components. Our techniques use fuzzy signatures to extend simple fuzzy systems to deal with data with such complex (sub-)structure. This produces effective fuzzy systems with wide applicability to real problems, in telecommunications, and petroleum reservoir data.Read moreRead less
Visual methods for advanced automation of underwater manipulation. This project will increase the autonomy of underwater robotic systems engaged in intervention and inspection tasks. Such activities are essential for the operation of subsea robotic systems used in offshore industries, scientific exploration and defence. Our approach will improve perception and situational awareness through the principled fusion of multiple navigation and camera sensors. We will use this improved scene understand ....Visual methods for advanced automation of underwater manipulation. This project will increase the autonomy of underwater robotic systems engaged in intervention and inspection tasks. Such activities are essential for the operation of subsea robotic systems used in offshore industries, scientific exploration and defence. Our approach will improve perception and situational awareness through the principled fusion of multiple navigation and camera sensors. We will use this improved scene understanding to effectively plan the motion of vehicles and manipulators through larger and more complex workspaces, enabling semi-supervised and autonomous task execution. Our project will demonstrate these capabilities in real-world deployments relevant to industry and marine science.Read moreRead less
3D Diffusion Models for Generating and Understanding 3D Scenes. Diffusion models, such as DALL-E2 and Imagen, have achieved remarkable success in generating photorealistic images and hold promise to solve long-standing computer vision problems. However, 3D scene generation remains unexplored. This research project aims to bridge the gap by developing 3D diffusion models capable of generating complete 3D scenes. This will advance our theoretical understanding of diffusion in complex 3D environmen ....3D Diffusion Models for Generating and Understanding 3D Scenes. Diffusion models, such as DALL-E2 and Imagen, have achieved remarkable success in generating photorealistic images and hold promise to solve long-standing computer vision problems. However, 3D scene generation remains unexplored. This research project aims to bridge the gap by developing 3D diffusion models capable of generating complete 3D scenes. This will advance our theoretical understanding of diffusion in complex 3D environments and open up new possibilities for applications in fields such as virtual reality, architecture, and city planning. The proposed 3D diffusion models will also enhance the accuracy of computer vision tasks related to 3D scene understanding, such as object detection, tracking, and semantic segmentation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100235
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure wil ....Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure will accelerate the pace of surveillance research and development in Australia, enhancing the competitiveness of both Australia's researchers and the businesses that will commercialise these researchers' discoveries.Read moreRead less
Intelligent Virtual Human Companions. This research aims to develop intelligent virtual human companions that can seemingly integrate our immediate physical environment and understand their surroundings including people’s emotions, behaviours, actions and interactions. Such a technology will be enabled by leveraging recent advances in mixed/augmented reality technologies, and by developing innovative artificial intelligence and computer vision and graphics algorithms for dynamic real-world envir ....Intelligent Virtual Human Companions. This research aims to develop intelligent virtual human companions that can seemingly integrate our immediate physical environment and understand their surroundings including people’s emotions, behaviours, actions and interactions. Such a technology will be enabled by leveraging recent advances in mixed/augmented reality technologies, and by developing innovative artificial intelligence and computer vision and graphics algorithms for dynamic real-world environments. Unlike robots, the proposed technology will be low cost, readily deployable and customisable, and will not have any physical limitations or maintenance requirements. It will thus have a wide range of applications from elderly care, healthcare care to educational training.Read moreRead less