Benefit Of 2D-strain Surveillance In Improving Cardiovascular Outcomes In Cancer Patients Undergoing Cardiotoxic Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$2,391,979.00
Summary
Cancer survivors are susceptible to heart failure (HF) caused by heart muscle damage from chemotherapy. The current testing for this problem is based on a measure that cannot identify minor changes of cardiac function. Cardiac strain is a sensitive new marker of cardiac function which is predictive of overt dysfunction & HF. This study seeks to identify whether strain can be used to assign treatments that lead to improved cardiac function and are eventually associated with a reduction in HF.
Dissolution of CaCO3 in sediments in an acidifying ocean. Dissolution of calcium carbonate (CaCO3) in sediments in the context of ocean acidification is poorly understood. This project will use in situ advective benthic chamber incubations and experimental manipulations under future ocean acidification scenarios to determine the controls on the dissolution of CaCO3 in sediments. This project is significant because changes in the dissolution of CaCO3 in sediments in an acidifying ocean are at lea ....Dissolution of CaCO3 in sediments in an acidifying ocean. Dissolution of calcium carbonate (CaCO3) in sediments in the context of ocean acidification is poorly understood. This project will use in situ advective benthic chamber incubations and experimental manipulations under future ocean acidification scenarios to determine the controls on the dissolution of CaCO3 in sediments. This project is significant because changes in the dissolution of CaCO3 in sediments in an acidifying ocean are at least as important, and potentially more important, than calcification to the future accretion and survival of carbonate ecosystems. It is expected that outcomes of this project will significantly advance our understanding of the drivers of the dissolution of CaCO3 in sediments and the functioning of globally important carbonate ecosystems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101290
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Unravelling the transformation pathways and fate of dissolved organic carbon and nitrogen in shallow coastal sediments. This project will significantly advance our understanding of the cycling of dissolved organic carbon and dissolved organic nitrogen in shallow coastal sediments, a potentially major part of global carbon and nitrogen cycles. This will have direct implications for the management and protection of Australian coastal systems and the world's oceans.
Linking phytoplankton to fisheries using zooplankton size spectra. This project aims to develop innovative numerical methods to understand the dynamics, carbon export, and trophic structure of zooplankton. The trophic links between phytoplankton, zooplankton and fisheries are unknown. The size- frequency distribution of zooplankton (size spectrum) is an innovative method for estimating their growth, predation and production as food for fish. Analysis of a global synthesis of zooplankton size dis ....Linking phytoplankton to fisheries using zooplankton size spectra. This project aims to develop innovative numerical methods to understand the dynamics, carbon export, and trophic structure of zooplankton. The trophic links between phytoplankton, zooplankton and fisheries are unknown. The size- frequency distribution of zooplankton (size spectrum) is an innovative method for estimating their growth, predation and production as food for fish. Analysis of a global synthesis of zooplankton size distributions from tropical to polar environments are expected to reveal these vital rates of pelagic ecosystems. The zooplankton rates will reveal, for the first time, the link between phytoplankton and fisheries, and will significantly improve ecosystem models and global assessments of environmental change.Read moreRead less
Seagrass denitrification: importance for global nitrogen budgets. The objective of this project is to use cutting-edge techniques to measure denitrification rates in communities dominated by different tropical and temperate seagrass species. Denitrification is a globally significant critical ecosystem process, but it is poorly understood in seagrass communities. This project is significant because of the potential importance of seagrass communities for nitrogen loss via denitrification in coasta ....Seagrass denitrification: importance for global nitrogen budgets. The objective of this project is to use cutting-edge techniques to measure denitrification rates in communities dominated by different tropical and temperate seagrass species. Denitrification is a globally significant critical ecosystem process, but it is poorly understood in seagrass communities. This project is significant because of the potential importance of seagrass communities for nitrogen loss via denitrification in coastal systems and the importance of coastal systems in the global nitrogen budget. The expected outcomes of this study may significantly advance our understanding of the functioning of coastal systems and global nitrogen budgets.Read moreRead less
Unravelling the drivers of greenhouse gas emissions in estuaries. The aim of this project is to understand and quantify the factors controlling the emission of carbon dioxide, methane and nitrous oxide from estuaries. Coastal systems play a disproportionately large role in the global emissions of greenhouse gases, but this is poorly quantified. The project plans to use a combination of continuous concentration and stable isotope measurements, process measurements and advanced numerical modelling ....Unravelling the drivers of greenhouse gas emissions in estuaries. The aim of this project is to understand and quantify the factors controlling the emission of carbon dioxide, methane and nitrous oxide from estuaries. Coastal systems play a disproportionately large role in the global emissions of greenhouse gases, but this is poorly quantified. The project plans to use a combination of continuous concentration and stable isotope measurements, process measurements and advanced numerical modelling across a range of undisturbed to disturbed systems. It is intended that this project will provide information for conceptualising, calibrating and verifying models, including green-house gas production. Good models, and the data that support them, such as that provided by this study, are critical for the efficient allocation of management resources in Australian coastal systems, including by our partners. The findings from this project will have direct implications to the management, rehabilitation and protection of waterways (including biodiversity) in Australia.Read moreRead less
Quantitative metrics for determining aquifer ecosystem state. Clean groundwater comes from dirty surface water by way of biological purification. This project will develop quantitative ways to assess groundwater ecosystems to ensure the sustainable extraction of water and maintenance of these crucial ecosystems.
Marine urban development: how can ecology inform the design of multifunctional artificial structures? This project aims to experimentally manipulate the design of artificial structures to achieve multipurpose ecological objectives. Artificial structures such as buildings and roads have featured in terrestrial urban landscapes for many years, but have only more recently begun encroaching on aquatic environments. Most marine artificial structures lack the innovative design solutions required to mi ....Marine urban development: how can ecology inform the design of multifunctional artificial structures? This project aims to experimentally manipulate the design of artificial structures to achieve multipurpose ecological objectives. Artificial structures such as buildings and roads have featured in terrestrial urban landscapes for many years, but have only more recently begun encroaching on aquatic environments. Most marine artificial structures lack the innovative design solutions required to mitigate their ecological impacts and provide essential ecosystem services such as pollution abatement. This project will investigate the efficacy of these designs with both classical measures of diversity and structure and novel measures of ecosystem function. The project aims to provide essential information to inform the design of future marine urban developments.Read moreRead less
The trophic ecosystem of a purpose-built, offshore artificial reef: do coastal currents supply sufficient nutrients for the local production of fish? Offshore artificial reefs may provide enhanced recreational fishing for an urbanized coast. This project will investigate the oceanographic and ecological processes around the new, design-specific, reefs off Sydney to determine if they actually produce fish, rather than simply attract fish. The project will influence the design of future reefs.
Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbi ....Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbial diversity patterns and organismal range in Australian marine systems. This is expected to be a crucial step for understanding the evolutionary and ecological processes that shape contemporary biodiversity.Read moreRead less