Media Formulations To Enhance Embryo Formation In Assisted Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$660,133.00
Summary
The increasing age of parenthood has led to an explosion in the demand for assisted reproductive technologies such as in vitro fertilisation (IVF). This procedure has a poor success rate and is limited by the ability of fertilised eggs to mature into early embryos in the lab prior to being transferred into women. We will develop new compounds that improve embryo growth in the clinic, which will improve IVF success rates.
Nicotinamide Adenine Dinucleotide (NAD+)-raising Agents For Improving Oocyte Quality
Funder
National Health and Medical Research Council
Funding Amount
$445,827.00
Summary
Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.
Life-saving chemo/radio-therapy commonly renders women and girls who survivor cancer infertile or sterile. We have discovered a new means of preserving the fertility of female mice exposed to chemo/radio therapy. In this project we will apply these advances to human ovarian tissue/eggs for the first time. We have access to these rare tissues for research purposes. This project will develop new approaches to fertility preservation for cancer survivors.
Discovery Early Career Researcher Award - Grant ID: DE120100796
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Androgens and ovarian function. This innovative project aims to identify the role androgens play in the complex processes required for successful ovarian follicle development and ovulation. The project aims to identify androgen regulated pathways that orchestrate follicle development, which will have significance in the control of fertility and the advancement of reproductive technologies.
Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in thei ....Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in their mental health and significant cost savings to the community.Read moreRead less
Cross-comparison, Validation And Performance Of Computerised Neuropsychological Assessment Devices In The Evaluation Of Mild Cognitive Impairment And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$700,482.00
Summary
With an ageing population and associated increase in dementia there will be increased demand for neuropsychological assessment, with insufficient trained personnel and resources to meet this demand. Computerised tests offer excellent opportunities for large scale implementation of cognitive screening and monitoring of older adults. This is the first study to systematically evaluate and compare several popular computerised neuropsychological assessment devices in elders with and without dementia.
Age at first birth, mode of conception and adjustment to parenthood. The trend to delayed childbearing is well-established, multiply determined and unlikely to change in the short term. This study will provide contemporary Australian evidence on the experience of becoming a parent at different ages, naturally and through assisted conception, for Australian men and women. Both risk and protective factors for older first-time parents will be identified, thus informing policy and services that can ....Age at first birth, mode of conception and adjustment to parenthood. The trend to delayed childbearing is well-established, multiply determined and unlikely to change in the short term. This study will provide contemporary Australian evidence on the experience of becoming a parent at different ages, naturally and through assisted conception, for Australian men and women. Both risk and protective factors for older first-time parents will be identified, thus informing policy and services that can better support Australian families with planning and rearing children. A key outcome will be a Parenting Decision-Aid to provide evidence-based reader-friendly information about the positives and negatives of first-time parenthood at different ages.Read moreRead less
Development of a non-invasive diagnostic test of Embryo Viability. A successful outcome will:
. improve the cost effectiveness of assisted reproductive technologies resulting in reduced health care costs and allowing greater use of ART in animal production
. by greater cost-effectiveness, facilitate greater access to these advanced technologies in less well developed economies
. build the national capacity in development and validation of biotech diagnostics
. build collaborative relationsh ....Development of a non-invasive diagnostic test of Embryo Viability. A successful outcome will:
. improve the cost effectiveness of assisted reproductive technologies resulting in reduced health care costs and allowing greater use of ART in animal production
. by greater cost-effectiveness, facilitate greater access to these advanced technologies in less well developed economies
. build the national capacity in development and validation of biotech diagnostics
. build collaborative relationship between the CI, University of Sydney and a leading industry partner (Cook Australia)
. lead to significant new fundamental knowledge in embryology that will be of major International significance
Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100082
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
FACSAria III - Fluorescence activated cell sorter. Flow cytometry is a technique for counting and examining microscopic particles, such as cells and chromosomes, by suspending them in a stream of fluid and passing them by an electronic detection apparatus. The FACSAria III cell sorter will be used to establish a core facility for sorting cells. The outcomes from using this technology are a better understanding cellular and genetic understanding of cancer, respiratory diseases, reproduction and ....FACSAria III - Fluorescence activated cell sorter. Flow cytometry is a technique for counting and examining microscopic particles, such as cells and chromosomes, by suspending them in a stream of fluid and passing them by an electronic detection apparatus. The FACSAria III cell sorter will be used to establish a core facility for sorting cells. The outcomes from using this technology are a better understanding cellular and genetic understanding of cancer, respiratory diseases, reproduction and birth. Read moreRead less
Targeted Disruption Of Lipoxygenase Enzymes To Prevent Oxidative Stress-mediated Pathologies In The Male Germline
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
An estimated 80 million individuals suffer from infertility globally with at least 50% of these cases due to defects in sperm function. Unfortunately, due to a severe lack of knowledge surrounding sperm biology and dysfunction, no successful curative or preventative measures have been established. My project will study why sperm cells die and investigate new ways to limit cellular stress so we can develop new therapeutic strategies to mitigate the growing problems in male reproductive health.