Metabolic And Molecular Basis Of Embryo Signalling
Funder
National Health and Medical Research Council
Funding Amount
$409,836.00
Summary
Cells in the body are powered by mitochondria that essentially generate the energy required for development. This grant will determine how the environment affects the mitochondria in the developing embryo and determine the impacts to the embryo and pregnancy if a mitochondria is partially shut down.
Improving Oocyte Mitochondrial DNA Copy Number To Enhance Female Reproductive Capacity.
Funder
National Health and Medical Research Council
Funding Amount
$670,867.00
Summary
Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.
Health And Fertility Of Young Men Conceived Using Intra-cytoplasmic Sperm Injection
Funder
National Health and Medical Research Council
Funding Amount
$362,570.00
Summary
The injection of a single sperm into the egg (ICSI) has been the main IVF treatment for men with poor sperm quality since 1993 but is now often used for other types of infertility. Concern has been raised about the health of the children. We will approach >800 parents and their adult sons conceived using ICSI and will assess his general health and development, and fertility. This work will improve patient counselling and practice guidelines, and direct research into the safety of ICSI.
Clinical Review Of A Cohort Aged 22-33 Years Conceived Using Assisted Reproductive Technologies
Funder
National Health and Medical Research Council
Funding Amount
$946,454.00
Summary
In a recent study, using telephone-interviews, we compared the health and wellbeing of 547 singleton young adults born following assisted reproductive technologies (ART), with 549 matched controls. Reviewing their health when they are 22-33 years is possible because of their ongoing interest. We have a protocol in place to measure their cardiac and respiratory function and other aspects of growth and development. Our findings will fill a major knowledge gap about the longer term safety of ART.
Impact and Effectiveness of Personal Ventilation in Open Plan Offices: a study of the Task Air system. Centralised air-conditioning systems are the standard for commercial office buildings in Australia. These systems are energy intensive, typically accounting for around 50% of building energy use. However, lack of occupant control over set temperatures or air movement tends to reduce thermal comfort, which can adversely affect worker productivity. The benefit of this project is that it will qu ....Impact and Effectiveness of Personal Ventilation in Open Plan Offices: a study of the Task Air system. Centralised air-conditioning systems are the standard for commercial office buildings in Australia. These systems are energy intensive, typically accounting for around 50% of building energy use. However, lack of occupant control over set temperatures or air movement tends to reduce thermal comfort, which can adversely affect worker productivity. The benefit of this project is that it will quantify the improvements to occupant comfort and energy savings possible with a PV system. This study will enable PV systems to be evaluated as an alternative to traditional air-conditioning, thereby demonstrating their effectiveness as a means of improving the sustainability rating of commercial office buildings in Australia.Read moreRead less
Defining the pathways of developmental brain injury, for a healthy start to life. Injury to the developing brain, whether sustained during pregnancy or at birth, is the underlying cause of many cognitive and motor disabilities, including cerebral palsy. This project will identify the cellular pathways that cause developmental brain injury, arising from the three principal complications of pregnancy or birth; intrauterine growth restriction (IUGR), preterm birth with/without intrauterine infectio ....Defining the pathways of developmental brain injury, for a healthy start to life. Injury to the developing brain, whether sustained during pregnancy or at birth, is the underlying cause of many cognitive and motor disabilities, including cerebral palsy. This project will identify the cellular pathways that cause developmental brain injury, arising from the three principal complications of pregnancy or birth; intrauterine growth restriction (IUGR), preterm birth with/without intrauterine infection and birth asphyxia. This project will utilise this knowledge of the causal pathways leading to brain injury to implement targeted therapies to reduce injury or repair the brain. It will progress fundamental biomedical discoveries into clinical practice to decrease the incidence and severity of newborn brain injury and cerebral palsy.Read moreRead less
A Consumer-centred Intervention Designed To Improve Healthy Lifestyle Behaviours And Weight Management In Preconception Women
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Healthy weight before conception plays a crucial role in the health of future generations. Identifying unique preconception groups of women who are most likely to respond to and engage with health promotion programs will improve effectiveness of obesity prevention initiatives. This research will inform and develop a tailored preconception health promotion program that will address both individual and population needs- Australia’s first consumer-centred approach to preconception health promotion.
Is SPINT1 a key regulator of placental development? . The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and expansion o ....Is SPINT1 a key regulator of placental development? . The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and expansion of the placental exchange interface which is critical for offspring survival.
The project will increase understanding of placental development, enhance collaboration and research knowhow, and promote future applied projects in all species that reproduce via placental support.Read moreRead less
A Unified Grid Programming Methodology for Global e-Science. This project will contribute to the national benefit in three important ways. First, we will build a set of novel e-Science applications as demonstrator projects in areas of national priority. These will have enormous economic impact in areas ranging from environmental management to health. Second, we will build software infrastructure that will have both commercial and strategic value in its own right. Third, we shall build a critical ....A Unified Grid Programming Methodology for Global e-Science. This project will contribute to the national benefit in three important ways. First, we will build a set of novel e-Science applications as demonstrator projects in areas of national priority. These will have enormous economic impact in areas ranging from environmental management to health. Second, we will build software infrastructure that will have both commercial and strategic value in its own right. Third, we shall build a critical mass of expertise that bridges the physical sciences and computer science. The support provided to this proposal will allow multi-disciplinary teams to address scientific problems of significant scale.Read moreRead less
Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Austral ....Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Australian research is at the forefront in steel and composite structures, and this project will strengthen Australia's positioning in the discipline by developing transparent design and assessment procedures from an efficient algorithm that delivers hands-on guidance for engineering practitioners.Read moreRead less