Is SPINT1 a key regulator of placental development? . The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and expansion o ....Is SPINT1 a key regulator of placental development? . The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and expansion of the placental exchange interface which is critical for offspring survival.
The project will increase understanding of placental development, enhance collaboration and research knowhow, and promote future applied projects in all species that reproduce via placental support.Read moreRead less
Design and analysis of optimum space-frequency-time codes for multi-rate OFDM Systems. This research work contributes to the ones of the major national
research priorities, the frontier ICT technology. It addresses the issues of a frontier ICT technology. Output of the project will place the Australia in the map of 4-th generation mobile and wireless communications research. These results will also influence the implementation aspects of future mobile communication systems and
attract the att ....Design and analysis of optimum space-frequency-time codes for multi-rate OFDM Systems. This research work contributes to the ones of the major national
research priorities, the frontier ICT technology. It addresses the issues of a frontier ICT technology. Output of the project will place the Australia in the map of 4-th generation mobile and wireless communications research. These results will also influence the implementation aspects of future mobile communication systems and
attract the attention of the international community. Other major
national benefit of the project is the training of PhD students
and the production of potential researchers for 4G research.Read moreRead less
A neuromorphic binaural hearing sensor. A neuromorphic binaural hearing sensor will be created. The system includes two cochleae and targeted processing pathways in the auditory brainstem that aid in solving the Cocktail Party Problem: i.e. foreground-background sound separation, sound localisation, and sound recognition. The VLSI circuits will enable real-time implementation of complex auditory models. As we develop our VLSI binaural ear, we will experiment with afferent (feed forward) and ....A neuromorphic binaural hearing sensor. A neuromorphic binaural hearing sensor will be created. The system includes two cochleae and targeted processing pathways in the auditory brainstem that aid in solving the Cocktail Party Problem: i.e. foreground-background sound separation, sound localisation, and sound recognition. The VLSI circuits will enable real-time implementation of complex auditory models. As we develop our VLSI binaural ear, we will experiment with afferent (feed forward) and efferent (feed back) auditory signal processing that is similar to real auditory systems and that demonstrate efficient, effective, and low-power signal processing algorithms for binaural (two-sensor) hearing systems.Read moreRead less
Hydrogen production from the anaerobic digestion of organic waste using a novel membrane. Solid organic waste is a potentially large, decentralized and sustainable source of hydrogen. The potential hydrogen yield from the anaerobic digestion of solid organic waste in Sydney alone could power over 750,000 passenger vehicles. Hydrogen is always generated in the digestion of organic material, but under natural conditions it is scavenged by methanogens. Recently developed silica membranes are sel ....Hydrogen production from the anaerobic digestion of organic waste using a novel membrane. Solid organic waste is a potentially large, decentralized and sustainable source of hydrogen. The potential hydrogen yield from the anaerobic digestion of solid organic waste in Sydney alone could power over 750,000 passenger vehicles. Hydrogen is always generated in the digestion of organic material, but under natural conditions it is scavenged by methanogens. Recently developed silica membranes are selectively and highly permeable to hydrogen, and these can be used to draw hydrogen from the digester. The digester will be run at high temperatures (>65oC) because this favours organisms that produce hydrogen over methanogens. Anaerobic digesters are well established in Europe and at least 3 municipal plants already exist in Australia.Read moreRead less
Next-Generation Solvers for Complex Microwave Engineering Problems. This project aims to design a complementary physics-guided, data-driven method that can accurately solve complex microwave engineering problems in a timely manner. The primary bottleneck so far preventing that approach, which is the disparity between the trained theoretical model and reality, will be overcome using a multi-frequency complex-valued domain adaptation technique. The method will use deep neural networks to reliably ....Next-Generation Solvers for Complex Microwave Engineering Problems. This project aims to design a complementary physics-guided, data-driven method that can accurately solve complex microwave engineering problems in a timely manner. The primary bottleneck so far preventing that approach, which is the disparity between the trained theoretical model and reality, will be overcome using a multi-frequency complex-valued domain adaptation technique. The method will use deep neural networks to reliably learn the physical concepts of microwave engineering problems. This project will have significant economic and societal benefits, such as supporting the efficient design, installation and operation of communication systems, mining, infrastructure inspection, security, remote sensing, and microwave imaging. Read moreRead less
Design of Planar Microwave Components and Sub-systems for Wideband Applications. The present research proposal will support the development of the Australian wireless communication industries by providing them with new solutions of fully integrated low-profile and compact size wideband wireless sub-systems, as demanded by emerging wideband applications. This goal will be accomplished by applying a new technique to the design of planar microwave circuits. The proposed solution should lead to impr ....Design of Planar Microwave Components and Sub-systems for Wideband Applications. The present research proposal will support the development of the Australian wireless communication industries by providing them with new solutions of fully integrated low-profile and compact size wideband wireless sub-systems, as demanded by emerging wideband applications. This goal will be accomplished by applying a new technique to the design of planar microwave circuits. The proposed solution should lead to improved competitiveness of the Australian communication companies in a global wireless communications market.Read moreRead less
Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations t ....Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations that optimise plant yield and fitness will be defined and explored in other, more complex, cereals such as wheat. Expected outcomes will be fundamental breakthroughs in understanding how plants respond to, and buffer, the effects of heat to lead to translational breeding strategies that bolster grain yield.Read moreRead less
How do mammalian germ cells transition from mitosis to meiosis? This project aims to determine how germ cells are regulated in the mammalian embryo. Germ cells go on to form the sperm and eggs and are, therefore, critical for reproduction. In particular, this project expects to generate new knowledge about the process of meiosis, a cellular process that is specific to the germ cells. Expected outcomes will inform efforts to control fertility and infertility in livestock, humans and other mammali ....How do mammalian germ cells transition from mitosis to meiosis? This project aims to determine how germ cells are regulated in the mammalian embryo. Germ cells go on to form the sperm and eggs and are, therefore, critical for reproduction. In particular, this project expects to generate new knowledge about the process of meiosis, a cellular process that is specific to the germ cells. Expected outcomes will inform efforts to control fertility and infertility in livestock, humans and other mammalian animals (e.g. pets and endangered species). They are also likely to inform the discipline of stem cell biology in general.Read moreRead less
Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new know ....Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new knowledge that will challenge current concepts of mammalian growth control. The outcomes will enhance Australia's international reputation in the fields of physiology, immunology and developmental biology. Read moreRead less
Estrogen signalling in gonadotropes. Estrogen action is a normal prerequisite for cyclic function of reproduction in the female, but little is known about how this important hormone acts in the relevant cells of the pituitary gland (gonadotropes). In order to gain information on normal function, we will conduct studies on gonadotropes treated with estrogen in a range of paradigms. The information will be valuable in understanding normal reproduction, but will also form the basis of further studi ....Estrogen signalling in gonadotropes. Estrogen action is a normal prerequisite for cyclic function of reproduction in the female, but little is known about how this important hormone acts in the relevant cells of the pituitary gland (gonadotropes). In order to gain information on normal function, we will conduct studies on gonadotropes treated with estrogen in a range of paradigms. The information will be valuable in understanding normal reproduction, but will also form the basis of further studies to investigate the effects of drugs that affect estrogen action and environmental estrogens. Read moreRead less