Improving Oocyte Mitochondrial DNA Copy Number To Enhance Female Reproductive Capacity.
Funder
National Health and Medical Research Council
Funding Amount
$670,867.00
Summary
Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.
Discovery Early Career Researcher Award - Grant ID: DE160101394
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Early developmental influences on neocortical organisation. This project seeks to identify the influence of preceding developmental stages on the correct formation of the brain. Development is a sequence of transformations where every stage depends on the outcome of previous stages. The project intends to examine how the early sensory periphery, early-born brain circuits, and intrinsic neuronal interactions affect the subsequent organisation of the cerebral cortex – a mammal-specific brain regio ....Early developmental influences on neocortical organisation. This project seeks to identify the influence of preceding developmental stages on the correct formation of the brain. Development is a sequence of transformations where every stage depends on the outcome of previous stages. The project intends to examine how the early sensory periphery, early-born brain circuits, and intrinsic neuronal interactions affect the subsequent organisation of the cerebral cortex – a mammal-specific brain region responsible for perception, motor planning and cognition. It expects to provide novel mechanistic and conceptual insights into the process of normal brain development and more general biological phenomena, such as development and evolution. It may also provide insights into several genetic and non-genetic causes of brain malformations.Read moreRead less
Dissecting the impact of stress on reproduction: Novel peptide mediates inhibitory effects of stress on female reproduction. This research proposal offers a pioneering opportunity to develop treatments that overcome the negative impact of stress on reproduction. Specifically, knowledge generated in this project will be vital in the development of strategic defences against the impact of stress on reproduction. This project fundamentally addresses Research Priority 2: Promoting and maintaining go ....Dissecting the impact of stress on reproduction: Novel peptide mediates inhibitory effects of stress on female reproduction. This research proposal offers a pioneering opportunity to develop treatments that overcome the negative impact of stress on reproduction. Specifically, knowledge generated in this project will be vital in the development of strategic defences against the impact of stress on reproduction. This project fundamentally addresses Research Priority 2: Promoting and maintaining good health. Given that suppression of reproduction by stress occurs in all mammalian species including humans, domestic animals and wildlife, being able to prevent or overcome stress-induced reproductive dysfunction will generate significant health, social, economic and ecological benefits. Read moreRead less
Dynamic phased array antennas for terahertz detection and ranging. The project aims to create reciprocal electrically-tuneable phased array antennas for terahertz waves. The antennas will comprise varactor diodes, analogue phase shifters, and dielectric resonator arrays to rapidly transmit and receive beams with high directivity and performance. The intended outcome is an integrated platform for short-range terahertz detection and ranging. This platform could be used in personal radar and drone- ....Dynamic phased array antennas for terahertz detection and ranging. The project aims to create reciprocal electrically-tuneable phased array antennas for terahertz waves. The antennas will comprise varactor diodes, analogue phase shifters, and dielectric resonator arrays to rapidly transmit and receive beams with high directivity and performance. The intended outcome is an integrated platform for short-range terahertz detection and ranging. This platform could be used in personal radar and drone-based radar, and high-contrast standoff detection. The project could benefit public security and welfare.Read moreRead less
Hybrid cooling for coal fired power stations. Water shortage is a nation wide problem facing Australian industries. The project will directly benefit the Victorian power industry through water saving. If the new proposed hybrid cooling system concept is proved to be practically feasible, it will put the Australian power industry in a strong competitive position in terms of its efficiencies and waste heat recovery technology. Lowering the temperature of water into the cooling tower by 2 degree, b ....Hybrid cooling for coal fired power stations. Water shortage is a nation wide problem facing Australian industries. The project will directly benefit the Victorian power industry through water saving. If the new proposed hybrid cooling system concept is proved to be practically feasible, it will put the Australian power industry in a strong competitive position in terms of its efficiencies and waste heat recovery technology. Lowering the temperature of water into the cooling tower by 2 degree, by using the hybrid cooling system, it would save over 17,500,000 tons of makeup water per year for the Victorian power industry alone. At the same time, the waste heat recovered by the heat pump can be fed back to the power generation cycle. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561030
Funder
Australian Research Council
Funding Amount
$441,100.00
Summary
Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiative ....Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiatives in developmental and cellular biology. This large-scale, high-resolution expression profiling infrastructure is required to maintain international competitiveness and will dramatically improve our gene discovery, functional assessment and understanding of vertebrate development.Read moreRead less
Easing the Squeeze: Dynamic and Distributed Resource Allocation with Cognitive Radio. The radio spectrum is a scarce and valuable natural resource which is being squeezed by the rapid growth in wireless communications. Cognitive radios make efficient use of radio spectrum by dynamically reusing frequencies. This requires cognitive radios to sense the local environment and to control the interference caused to existing users of the spectrum. This project will design novel dynamic and distributed ....Easing the Squeeze: Dynamic and Distributed Resource Allocation with Cognitive Radio. The radio spectrum is a scarce and valuable natural resource which is being squeezed by the rapid growth in wireless communications. Cognitive radios make efficient use of radio spectrum by dynamically reusing frequencies. This requires cognitive radios to sense the local environment and to control the interference caused to existing users of the spectrum. This project will design novel dynamic and distributed resource allocation algorithms for cognitive radios in order to significantly improve their performance using techniques from extreme value theory, game theory and mechanism design and large random matrix theory. Read moreRead less
High performance conductive mesoporous carbon electrodes: a low energy desalination alternative. The high cost of existing desalination technology has limited its wider application. There is an urgent need for alternatives which require less energy than current methods. The proposed electrosorption process utilising porous carbon electrodes has the advantage of very low energy demand. Electrosorption therefore has the opportunity to become an alternative desalination option for application in a ....High performance conductive mesoporous carbon electrodes: a low energy desalination alternative. The high cost of existing desalination technology has limited its wider application. There is an urgent need for alternatives which require less energy than current methods. The proposed electrosorption process utilising porous carbon electrodes has the advantage of very low energy demand. Electrosorption therefore has the opportunity to become an alternative desalination option for application in a national and global water desalination market. Advancement in water desalination technology has the potential for a profound social, economical and environmental impact. This vital research is aligned with the National Research Priority 1, An Environmentally Sustainable Australia; Priority Goal: Water, A critical resource.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883078
Funder
Australian Research Council
Funding Amount
$356,000.00
Summary
Liquid Chromatography Tandem Mass Spectrometry Steroid Analysis Facility. This first of a new generation of ultra-sensitive analytical mass spectrometers for small molecules will be established as a national assay facility allowing all Australian researchers open access to a new dimension of highly accurate and simultaneous measurements of multiple bodily chemicals such as steroids, vitamins and hormones. It is crucial to developing new knowledge in basic, developmental and pathological cell bio ....Liquid Chromatography Tandem Mass Spectrometry Steroid Analysis Facility. This first of a new generation of ultra-sensitive analytical mass spectrometers for small molecules will be established as a national assay facility allowing all Australian researchers open access to a new dimension of highly accurate and simultaneous measurements of multiple bodily chemicals such as steroids, vitamins and hormones. It is crucial to developing new knowledge in basic, developmental and pathological cell biology and for underpinning commercial developments of new molecular targets for therapeutic drugs for many diseases including cancer, cardiovascular disease and reproductive disorders. This facility is pivotal to maintaining international competitiveness in many areas of biological research in national priority areas.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100048
Funder
Australian Research Council
Funding Amount
$466,097.00
Summary
Ammonium-selective membranes to shift water industry into circular economy. The project aims to develop ammonium-selective membranes which are urgently needed in Australian key industries for sustainable ammonia recovery. The project expects to construct the membranes to achieve desirable pore size and surface functionality for fast and selective ammonia transport. The developed membranes should make ammonia recovery from wastewater more effective and sustainable, leading to the healthy waterway ....Ammonium-selective membranes to shift water industry into circular economy. The project aims to develop ammonium-selective membranes which are urgently needed in Australian key industries for sustainable ammonia recovery. The project expects to construct the membranes to achieve desirable pore size and surface functionality for fast and selective ammonia transport. The developed membranes should make ammonia recovery from wastewater more effective and sustainable, leading to the healthy waterway and reduced energy for both ammonia production and removal. Recovered ammonia expects to produce valuable products, supporting agriculture industry and hydrogen economy. The developed membranes should enable water industry's shift into circular economy, providing significant economic and environmental benefits to Australia.Read moreRead less