Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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Discovery Early Career Researcher Award - Grant ID: DE220100032
Funder
Australian Research Council
Funding Amount
$379,264.00
Summary
Banking on spermatogonial stem cells to safeguard Australian native fauna. Spermatogonial stem cells in the testis are an untapped resource for species conservation. This project aims to characterise metabolic pathways that control spermatogonial stem cell function, and define the conserved nature of these pathways between model species (mouse) and vulnerable Australian native fauna. Expected outcomes of this project include an enhanced capacity to culture koala spermatogonia in vitro, which wil ....Banking on spermatogonial stem cells to safeguard Australian native fauna. Spermatogonial stem cells in the testis are an untapped resource for species conservation. This project aims to characterise metabolic pathways that control spermatogonial stem cell function, and define the conserved nature of these pathways between model species (mouse) and vulnerable Australian native fauna. Expected outcomes of this project include an enhanced capacity to culture koala spermatogonia in vitro, which will be a first step towards using spermatogonial biobanking as a tool to maintain genetic diversity in this species. Outcomes from this study should provide significant benefits in safeguarding our unique Australian native species, which is of particular importance following the catastrophic 2019/20 bushfire season.Read moreRead less
Enabling wide area mm-wave mobile broadband networks. This project will define a new architecture and algorithms based around a network of access points with overlapping coverage that will support broadband, wide-area services to mobile users in mm-wave bands. The project will develop tools to characterise the information carrying capacity of this network, and tradeoffs between key parameters. The outcomes will be used by Mobile Network Operators in planning their deployments and developing thei ....Enabling wide area mm-wave mobile broadband networks. This project will define a new architecture and algorithms based around a network of access points with overlapping coverage that will support broadband, wide-area services to mobile users in mm-wave bands. The project will develop tools to characterise the information carrying capacity of this network, and tradeoffs between key parameters. The outcomes will be used by Mobile Network Operators in planning their deployments and developing their operations software to deliver diverse and flexible data services. The benefit will be an unlocking of radio spectrum beyond isolated hot spots, supporting vastly greater traffic densities and data rates worth billions of dollars to the economy.
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Novel inkjet-printed organic solvent nanofiltration membranes. The pharmaceutical industry is one of fastest growing industries in Australia. Manufacturing pharmaceutical products requires the use of hazardous and expensive organic solvents, which are toxic for the environment and expensive to recover due to the energy intensive thermal process required. This project aims to discover and manufacture a novel, low-cost, chemically robust nanomaterial-based membrane using an industry scalable inkje ....Novel inkjet-printed organic solvent nanofiltration membranes. The pharmaceutical industry is one of fastest growing industries in Australia. Manufacturing pharmaceutical products requires the use of hazardous and expensive organic solvents, which are toxic for the environment and expensive to recover due to the energy intensive thermal process required. This project aims to discover and manufacture a novel, low-cost, chemically robust nanomaterial-based membrane using an industry scalable inkjet printing process. The membrane will be resistant to organic solvents while efficiently recovering valuable and hazardous organic solvents with minimum environmental footprint. It will effectively provide for the future growth of the Australian pharmaceutical industry while also having global applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100016
Funder
Australian Research Council
Funding Amount
$432,572.00
Summary
Wireless Communications for Human-Machine Collaboration. Industry 5.0 is a new industry transformation vision where the focus lies on the interaction between humans and machines. Wireless human-machine collaboration (HMC) will play a central role in a wide range of industrial applications in Industry 5.0. This project aims to develop new fundamental theories of wireless HMC and enable novel wireless communications designs to accommodate the stringent and dynamic requirements of HMC with performa ....Wireless Communications for Human-Machine Collaboration. Industry 5.0 is a new industry transformation vision where the focus lies on the interaction between humans and machines. Wireless human-machine collaboration (HMC) will play a central role in a wide range of industrial applications in Industry 5.0. This project aims to develop new fundamental theories of wireless HMC and enable novel wireless communications designs to accommodate the stringent and dynamic requirements of HMC with performance guarantees. The project will provide innovative solutions to advanced manufacturing, remote healthcare, mining, and warehousing and will benefit Australia’s digital transformation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100103
Funder
Australian Research Council
Funding Amount
$459,674.00
Summary
Fortifying animal and plant germ cells against proteotoxic stress. Cellular stress is responsible for widespread inefficiencies in plant and animal reproduction. Using high resolution proteomics and cryo-electron microscopy, this project aims to investigate how plant and animal germ cells respond to environmental stresses that are known to disrupt fertility, and assess two novel strategies to decrease the sensitivity of cells to stress. This project is expected to generate new global knowledge i ....Fortifying animal and plant germ cells against proteotoxic stress. Cellular stress is responsible for widespread inefficiencies in plant and animal reproduction. Using high resolution proteomics and cryo-electron microscopy, this project aims to investigate how plant and animal germ cells respond to environmental stresses that are known to disrupt fertility, and assess two novel strategies to decrease the sensitivity of cells to stress. This project is expected to generate new global knowledge in the area of fertility regulation with the potential to improve the tolerance of crop species to heat stress, prevent economic losses and help to secure future food production. Further, this project has the intended benefit of improving the fertility of animal species that suffer from stress-induced infertility.
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Seeing the light: high-power visible-light generation using silicate fibre. Unlike their near-infrared counterparts, visible-light-emitting lasers are inefficient and complicated, impacting their broader deployment in industry, medicine, and telecommunications. To address this, we will create a new class of laser and amplifier based on an entirely new doped silicate glass fibre that will display low background loss and resilience to photodegradation from high-power visible light. This will solve ....Seeing the light: high-power visible-light generation using silicate fibre. Unlike their near-infrared counterparts, visible-light-emitting lasers are inefficient and complicated, impacting their broader deployment in industry, medicine, and telecommunications. To address this, we will create a new class of laser and amplifier based on an entirely new doped silicate glass fibre that will display low background loss and resilience to photodegradation from high-power visible light. This will solve one of the last important problems in fibre laser research. The primary outcome will be a series of high-power continuous-wave, ultrashort-pulse, all-fibre lasers emitting at yellow and red wavelengths, with significant benefits for space, defence, manufacturing, and human health.Read moreRead less
Multi-beam Transmitarrays for Unmanned Aerial Vehicle Communications. This project aims to develop fundamental technologies for multi-beam conformal transmitarrays with independent beam steering capabilities for unmanned aerial vehicle (UAV) communications. Compared to current UAV antennas, the proposed antennas can be flush mounted to the body of UAVs, improving aerodynamic performance while also achieving significantly higher data rates for wireless connectivity. This project is expected to ge ....Multi-beam Transmitarrays for Unmanned Aerial Vehicle Communications. This project aims to develop fundamental technologies for multi-beam conformal transmitarrays with independent beam steering capabilities for unmanned aerial vehicle (UAV) communications. Compared to current UAV antennas, the proposed antennas can be flush mounted to the body of UAVs, improving aerodynamic performance while also achieving significantly higher data rates for wireless connectivity. This project is expected to generate scientific breakthroughs in many aspects of antenna research and enable UAVs to leverage big data technologies by transmitting/receiving large amounts of data, thus serving as a powerful tool for emergency management and for transforming many industry sectors, such as agriculture, food and water.Read moreRead less
Digitally Assisted Power Amplifier Design with Enhanced Energy Efficiency. The project aims to advance design techniques for power amplifiers operating in the recently allocated spectrum for 5G New Radio, from approximately 24 GHz to 52 GHz. The intended outcome is a compact and high efficiency transmitter using digitally assisted power amplifier design techniques in low-cost Complementary Metal–Oxide–Semiconductor (CMOS) technology. Such innovation will have significant impacts on our daily lif ....Digitally Assisted Power Amplifier Design with Enhanced Energy Efficiency. The project aims to advance design techniques for power amplifiers operating in the recently allocated spectrum for 5G New Radio, from approximately 24 GHz to 52 GHz. The intended outcome is a compact and high efficiency transmitter using digitally assisted power amplifier design techniques in low-cost Complementary Metal–Oxide–Semiconductor (CMOS) technology. Such innovation will have significant impacts on our daily life, as it will build the hardware foundation for the next generation of wireless systems. Consequently, various emerging applications such as virtual/augmented reality will be supported, maintaining national leadership in the development of wireless technology, and providing economic benefits for Australian industries.Read moreRead less
Wireless Integrated Circuits for the Era of 6G: System-in-a-Package. The aim of this project is to build a hardware foundation for future wireless integrated circuits, using a combination of silicon and compound semiconductor technologies. The project will generate knowledge for circuit design and system integration to pivot towards the engineering of emerging 6G technology. Expected outcomes include a transceiver-in-package using multiple semiconductor technologies and the development of sovere ....Wireless Integrated Circuits for the Era of 6G: System-in-a-Package. The aim of this project is to build a hardware foundation for future wireless integrated circuits, using a combination of silicon and compound semiconductor technologies. The project will generate knowledge for circuit design and system integration to pivot towards the engineering of emerging 6G technology. Expected outcomes include a transceiver-in-package using multiple semiconductor technologies and the development of sovereign design capabilities. The results will constitute an important step towards implementing 6G. Benefits for Australia include the development of early career workers, generation of intellectual property, and securing social and economic benefits for Australians through application of this next-generation technology.Read moreRead less