Engineering an environmentally-friendly metered dose inhaler. This project aims to deliver a novel simulation framework to accurately predict the behaviour of metered dose inhaler sprays using advanced numerical methods for flash-evaporating turbulent flows developed by the investigators. The project expects to generate new knowledge of the complex physics which occur in these devices through a first of its kind combination of unsteady non-equilibrium thermodynamics, turbulence and spray models. ....Engineering an environmentally-friendly metered dose inhaler. This project aims to deliver a novel simulation framework to accurately predict the behaviour of metered dose inhaler sprays using advanced numerical methods for flash-evaporating turbulent flows developed by the investigators. The project expects to generate new knowledge of the complex physics which occur in these devices through a first of its kind combination of unsteady non-equilibrium thermodynamics, turbulence and spray models. Expected outcomes of this project include a novel ability to predict and optimise the performance of inhalers to suit environmentally-friendly replacement propellants. This will significantly benefit the pharmaceutical sector as it will accelerate the design of next-generation inhalers and propellants.Read moreRead less
Improving respiratory drug delivery through targeted nozzle design. The project aims to develop designs for inhaler components which significantly reduce the existing variability in the sprays they produce, as well as an enhanced capacity to predict inhaler performance through development of new empirical models. This project will combine recently developed synchrotron x-ray measurement techniques with traditional visible light diagnostics to develop a greater understanding of the link between t ....Improving respiratory drug delivery through targeted nozzle design. The project aims to develop designs for inhaler components which significantly reduce the existing variability in the sprays they produce, as well as an enhanced capacity to predict inhaler performance through development of new empirical models. This project will combine recently developed synchrotron x-ray measurement techniques with traditional visible light diagnostics to develop a greater understanding of the link between the geometry of pressurised, metered-dose inhaler components and the drug particles these devices produce. The long term benefit from this research will be improved delivery efficiency and shorter product development times, leading to reduced dose-rate costs. This understanding will enable the development of the next generation of treatment devices with enhanced efficiency in delivery of the drugs used to treat these diseases and reduced costs per dose.Read moreRead less
Enabling precise droplet control in hydrofluorocarbon free sprays. This project aims to investigate the use of blended propellants to replace hydrofluorocarbons in technical aerosols. This project expects to generate new knowledge in the area of multiphase fluid mechanics and aerosol science through a combination of modeling, optical and synchrotron X-ray measurement techniques. Expected outcomes of this project include a capacity to develop environmentally friendly technical aerosol formulation ....Enabling precise droplet control in hydrofluorocarbon free sprays. This project aims to investigate the use of blended propellants to replace hydrofluorocarbons in technical aerosols. This project expects to generate new knowledge in the area of multiphase fluid mechanics and aerosol science through a combination of modeling, optical and synchrotron X-ray measurement techniques. Expected outcomes of this project include a capacity to develop environmentally friendly technical aerosol formulations which can match and potentially outperform currently available hydrofluorocarbon based products. This should provide significant benefits to the pharmaceutical industry through the generation of new knowledge regarding the fundamental physics of multicomponent sprays.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100018
Funder
Australian Research Council
Funding Amount
$362,441.00
Summary
Engineering suspended particle sprays through controlled cavitation. This project aims to use cavitation to engineer particle size in sprays of micronised particles suspended in a propellant, and develop a physical mechanism for this process. Understanding how cavitation affects the size of agglomerates in the liquid phase and droplet size in a spray is critical to developing spray devices that require precise control over the final particle size. This will be achieved through high-resolution op ....Engineering suspended particle sprays through controlled cavitation. This project aims to use cavitation to engineer particle size in sprays of micronised particles suspended in a propellant, and develop a physical mechanism for this process. Understanding how cavitation affects the size of agglomerates in the liquid phase and droplet size in a spray is critical to developing spray devices that require precise control over the final particle size. This will be achieved through high-resolution optical imaging techniques and synchrotron X-ray diagnostics. This project is expected to provide physical insight with applications for inhaled and topical pharmaceutical sprays, and industry spray drying of food products.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100222
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Time-resolved tomographic particle image velocimetry facility. The experimental information gained from measurements provided by this infrastructure will lead to significant advances in understanding turbulent flows and the dynamics of solid structures, which will impact a broad range of engineering and geophysical fields. Some specific examples include the development of efficient turbulence control strategies for the reduction of skin-friction drag and improved combustion processes, resulting ....Time-resolved tomographic particle image velocimetry facility. The experimental information gained from measurements provided by this infrastructure will lead to significant advances in understanding turbulent flows and the dynamics of solid structures, which will impact a broad range of engineering and geophysical fields. Some specific examples include the development of efficient turbulence control strategies for the reduction of skin-friction drag and improved combustion processes, resulting in not only better fuel efficiency for vehicles but also reduced CO2 and pollutant emissions. Significant advances can also be made in understanding the dispersion of pollutants in the atmosphere, wind turbine design and the development of lighter and stronger intelligent materials with improved fatigue life.Read moreRead less
Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
Wake dynamics of oscillating cylinder in steady currents. This project aims at advancing knowledge in flow/structure interactions and developing improved methodology for predicting wave and current loading on marine structures, which are vital in many practical applications such as extraction of oil and gas resources and renewable energy from the ocean. The improved methodology and much-needed database of hydrodynamic force coefficients developed through this project for estimating hydrodynamic ....Wake dynamics of oscillating cylinder in steady currents. This project aims at advancing knowledge in flow/structure interactions and developing improved methodology for predicting wave and current loading on marine structures, which are vital in many practical applications such as extraction of oil and gas resources and renewable energy from the ocean. The improved methodology and much-needed database of hydrodynamic force coefficients developed through this project for estimating hydrodynamic loading on marine structures will significantly reduce the high, costly uncertainly levels that are being experienced in the design, construction and maintenance of marine structures (and facilities) and increase the competiveness of Australian relevant industries. Read moreRead less
Understanding and modifying vortex structures in wind turbine wakes. At a fundamental research level, Australia's active participation in this area of national priority and research strength will be advanced through our published research, which will increase our understanding of wind turbine wakes and their effects in wind farms. This understanding will then be used to produce improved methods of predicting wind turbine performance. Such methods are needed by wind energy designers to produce b ....Understanding and modifying vortex structures in wind turbine wakes. At a fundamental research level, Australia's active participation in this area of national priority and research strength will be advanced through our published research, which will increase our understanding of wind turbine wakes and their effects in wind farms. This understanding will then be used to produce improved methods of predicting wind turbine performance. Such methods are needed by wind energy designers to produce better wind farms. It will also be used to recommend how to improve the aerodynamic design of turbine components, such as the blades and hub. Numerical tools will be developed for industry use, and training will be provided to personnel, thereby increasing the capabilities of Australia's growing wind energy industry.Read moreRead less
Unravelling the scale interactions of wall turbulence: experiment, physical modelling, next-generation numerical simulation. Turbulent fluid flows near solid surfaces are present in many areas of everyday life: from the drag experienced on air, sea and road vehicles, to governing the mixing processes in combustion chambers, and in the transport of pollutants and particulates in our cities and towns. Unfortunately our understanding of these complex flows is limited, and hence so to is our ability ....Unravelling the scale interactions of wall turbulence: experiment, physical modelling, next-generation numerical simulation. Turbulent fluid flows near solid surfaces are present in many areas of everyday life: from the drag experienced on air, sea and road vehicles, to governing the mixing processes in combustion chambers, and in the transport of pollutants and particulates in our cities and towns. Unfortunately our understanding of these complex flows is limited, and hence so to is our ability to model or control them. This project addresses this problem with the goal of providing new physical insights and models that can be used for efficient and accurate numerical simulations. The simulations will not only compute the average statistics but also the time-varying properties, which are crucial in many engineering and environmental processes.Read moreRead less
Microdynamic modelling and analysis of gas fluidization of particle mixtures. The project aims to develop a comprehensive understanding of the mechanisms governing the particle-fluid flow in gas fluidization of mixtures of particles of different sizes. This will be achieved through detailed analysis of the particle-particle and particle-fluid interactions on the basis of the microdynamic or particle scale results generated by the newly developed discrete simulation technique. The microscopic fin ....Microdynamic modelling and analysis of gas fluidization of particle mixtures. The project aims to develop a comprehensive understanding of the mechanisms governing the particle-fluid flow in gas fluidization of mixtures of particles of different sizes. This will be achieved through detailed analysis of the particle-particle and particle-fluid interactions on the basis of the microdynamic or particle scale results generated by the newly developed discrete simulation technique. The microscopic findings will be implemented in the macroscopic, continuum-based modelling and tested by comparing numerical and experimental results. It will significantly enhance the present capability of modelling particle-fluid flow in gas fluidization which is widely used in mineral/chemical industries.Read moreRead less