Discrete particle simulation of powder dispersion in pharmaceutical aerosol inhalers. A successful completion of the project will i) greatly enhance the Australian R&D profile and capabilities of both computational modelling and pharmaceutical aerosol research in the world; ii) provide an improved delivery of therapeutic dose to patients via inhalers with better performance to enhance the therapeutic benefits; iii) enable wide availability of inexpensive and effective pharmaceutical inhalation p ....Discrete particle simulation of powder dispersion in pharmaceutical aerosol inhalers. A successful completion of the project will i) greatly enhance the Australian R&D profile and capabilities of both computational modelling and pharmaceutical aerosol research in the world; ii) provide an improved delivery of therapeutic dose to patients via inhalers with better performance to enhance the therapeutic benefits; iii) enable wide availability of inexpensive and effective pharmaceutical inhalation products to the Australian community for the treatment of asthma and other diseases, iv) facilitate environmentally friendly technology since powder aerosol delivery does not require any harmful organic solvents to operate.Read moreRead less
Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol a ....Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol administration. Successful development of the technology will not only gain new knowledge in the key area of nanotechnology, but also lead to better inhalation therapy to benefit patients.Read moreRead less
Developing novel aerosol inhalers for pulmonary drug delivery from the fundamental understanding of powder dispersion mechanisms. The project seeks to understand how powder aerosol inhalers can be significantly improved. The outcome will provide therapeutic benefits to the Australian community for better treatment of respiratory diseases and facilitate environmentally friendly technology since these inhalers do not require any harmful organic solvents to operate.
Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery. A successful conclusion of this project will enhance substantially the competitiveness of Australia's research in functional nanomaterials and advanced biomaterials. The Australian pharmaceutical industry will gain through the ability to develop proprietary pharmaceutical formulations targeted towards taking advantage of the novel process. Patients of asthma, lung inf ....Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery. A successful conclusion of this project will enhance substantially the competitiveness of Australia's research in functional nanomaterials and advanced biomaterials. The Australian pharmaceutical industry will gain through the ability to develop proprietary pharmaceutical formulations targeted towards taking advantage of the novel process. Patients of asthma, lung infection and other serious health problems will benefit from an improved delivery of therapeutic dose at a much reduced cost. The technology is environmentally friendly as powder aerosol delivery does not require any harmful organic solvent to operate.Read moreRead less
High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful developme ....High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful development of the technology will position both Australia and the industry partner to take a lead in the application of this novel technology in pharmaceutical aerosols, and provides better inhalation therapy to benefit patients.Read moreRead less
Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within th ....Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within the Designated Research Priority of Frontier Technologies for Building and Transforming Australian Industries. Read moreRead less
Establishing the relationship between water characteristics and fouling of membranes used in water reuse. The project will result in the following significant benefits to the Australian and international partners: a state-of-the-art laboratory and semi-pilot system from which a full-scale system could be developed and tested, funded by the water industry; an outstanding research project for postgraduate students at the University of Technology, Sydney (UTS), Gwangji Institute of Science and Tech ....Establishing the relationship between water characteristics and fouling of membranes used in water reuse. The project will result in the following significant benefits to the Australian and international partners: a state-of-the-art laboratory and semi-pilot system from which a full-scale system could be developed and tested, funded by the water industry; an outstanding research project for postgraduate students at the University of Technology, Sydney (UTS), Gwangji Institute of Science and Technology, Korea (GIST) and Yale University; and fostering a culture of innovation in the wastewater industry in Australia, Korea and USA and contributing to the commercialization of research by UTS, GIST and YU.Read moreRead less
Fluidised bed biosorption-flocculation granular activated carbon (FBBSF-GAC) for membrane filtration in wastewater reuse. Water resource is limited and has been continuously decreasing. The idea of recycling and reusing of wastewater has been adopted for irrigation, industry and other non-potable uses. In Australia, wastewater reuse is now considered a key strategy for conserving water at national, state and local level. In this study, the proposed treatment unit is to produce a superior effluen ....Fluidised bed biosorption-flocculation granular activated carbon (FBBSF-GAC) for membrane filtration in wastewater reuse. Water resource is limited and has been continuously decreasing. The idea of recycling and reusing of wastewater has been adopted for irrigation, industry and other non-potable uses. In Australia, wastewater reuse is now considered a key strategy for conserving water at national, state and local level. In this study, the proposed treatment unit is to produce a superior effluent quality for water reuse while minimize membrane fouling of the membrane filtration system. Hence, it will benefit water industries globally and communities in Australia. There will be a major export opportunity from Australia to supply efficient, low-cost and sustainable flocculant together with an improved treatment system worldwide.Read moreRead less
Advanced technology for production of foreign proteins in plant cell and organ cultures. The aim of this project is to develop new technology for in vitro production of pharmaceutical proteins using plant tissue culture. Animal proteins such as antibodies are currently being produced using recombinant plant systems in bioreactors; however, transient gene expression using genetically-modified viruses has a range of potential benefits for substantially increasing foreign protein titres. Because vi ....Advanced technology for production of foreign proteins in plant cell and organ cultures. The aim of this project is to develop new technology for in vitro production of pharmaceutical proteins using plant tissue culture. Animal proteins such as antibodies are currently being produced using recombinant plant systems in bioreactors; however, transient gene expression using genetically-modified viruses has a range of potential benefits for substantially increasing foreign protein titres. Because viruses rapidly infect plant tissues and can be amplified to extremely high levels, this new method for in vitro foreign protein synthesis has considerable promise. This project will extend the existing science of plant tissue culture into new areas with commercial potential.Read moreRead less
Hanging sponge aerobic bioreactor and membrane - adsorption hybrid system: a novel two stage system in wastewater reuse. A novel two-stage system consisting of a downflow hanging sponge biological reactor (DHS) and submerged membrane-adsorption hybrid system (SMAS) will be developed in this study. The DHS modified to incorporate solid separation and superior organics, and nitrogen removal will be an excellent pretreatment system that features minimum energy requirement and on sludge production. ....Hanging sponge aerobic bioreactor and membrane - adsorption hybrid system: a novel two stage system in wastewater reuse. A novel two-stage system consisting of a downflow hanging sponge biological reactor (DHS) and submerged membrane-adsorption hybrid system (SMAS) will be developed in this study. The DHS modified to incorporate solid separation and superior organics, and nitrogen removal will be an excellent pretreatment system that features minimum energy requirement and on sludge production. The post treatment of SMAS is to be studied to optimize aeration, biological activity on activated carbon will remove the remaining organics, solids, bacteria and majority of viruses. The developed hybrid system will be a cost- effective system in water reuse in small communities.Read moreRead less