Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
Identification And Characterisation Of Novel Genes For Congenital Cataract
Funder
National Health and Medical Research Council
Funding Amount
$432,750.00
Summary
Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Au ....Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Australia over the past 5 years to determine the causative genes. A large number of families have been involved in the study and solid progress has been made in identifying mutations in cataract genes and understanding what effect these may have on the patient's prognosis. We have recently identified a new gene in a large Australian family with a syndrome of cataract, mental retardation and teeth problems. This syndrome, known as Nance-Horan syndrome was originally described in Australia 30 years ago and we have worked with the original family to find the exact gene responsible. We already know that this gene causes the same syndrome in other families and in this project we will examine whether it can cause cataract without the other features or mental retardation without cataract. We will perform a series of experiments to learn what this gene does and how it causes the disease. We have also selected 3 other very interesting families with congenital cataracts for further study as we either know already or strongly suspect that they will enable us to identify further new genes for cataract, and in one case mental retardation. Our work in other diseases indicates that understanding the genes in severe young onset cases can give valuable clues to the causes of age-related forms and may in the future enable new ways to prevent and treat the commonest cause of worldwide blindness.Read moreRead less
Evolution. Morphodynamics and History of the Younghusband Peninsula. This project will examine the history and evolution of the Sir Richard-Younghusband Peninsula (SRYP) complex barrier in SA. The aims are to derive a understanding of how the influences of relative sea-level changes, neotectonics, and sediment supply, can produce remarkably different responses in barrier development. No complex barrier (i.e. foredune ridges in one portion, transgressive dunefields in another) has ever been compr ....Evolution. Morphodynamics and History of the Younghusband Peninsula. This project will examine the history and evolution of the Sir Richard-Younghusband Peninsula (SRYP) complex barrier in SA. The aims are to derive a understanding of how the influences of relative sea-level changes, neotectonics, and sediment supply, can produce remarkably different responses in barrier development. No complex barrier (i.e. foredune ridges in one portion, transgressive dunefields in another) has ever been comprehensively drilled, dated, modelled, or examined in the context of indigenous occupation and oral histories in Australia. The study provides excellent analogues for barrier and dune response, and shoreline translation to varying rates of sea level rise, paralleling pressures facing all coastlines today.Read moreRead less
Clothes, fibres and filters that reduce pollution by micro and nano debris. This project aims to provide scientifically verified methods to avoid, intercept and redesign products that cause the most abundant type of marine plastic pollution – clothing fibres - which has increased by over 450% in 60 years. It will determine how natural and plastic fibres, clothing brands and washing machine filters, alter fibre emissions and ecological impacts. This will enable protocols to improve products and t ....Clothes, fibres and filters that reduce pollution by micro and nano debris. This project aims to provide scientifically verified methods to avoid, intercept and redesign products that cause the most abundant type of marine plastic pollution – clothing fibres - which has increased by over 450% in 60 years. It will determine how natural and plastic fibres, clothing brands and washing machine filters, alter fibre emissions and ecological impacts. This will enable protocols to improve products and the environment, and reduce health risks that will benefit the public, government regulation and companies in designing "eco-friendly" products.Read moreRead less
Fostering school attendance for students in Out-of-Home Care. This project aims to investigate why children and young people in Out-Of-Home-Care in Australia are absent from school far more than their peers. The project expects to generate new knowledge about the reasons for their absences and to develop solutions to improve attendance through: children’s own voices; detailed absence data; policy audit; and case studies of promising practice. Expected outcomes include a comprehensive conceptuali ....Fostering school attendance for students in Out-of-Home Care. This project aims to investigate why children and young people in Out-Of-Home-Care in Australia are absent from school far more than their peers. The project expects to generate new knowledge about the reasons for their absences and to develop solutions to improve attendance through: children’s own voices; detailed absence data; policy audit; and case studies of promising practice. Expected outcomes include a comprehensive conceptualisation of absences including those triggered by schools or the care context; and an evidence-informed, child-centred framework to enable attendance and, thereby, improved educational outcomes. This should provide significant social and economic benefits both for children in care and for the community. Read moreRead less
Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professiona ....Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professionals to identify early those youth at risk of having poor psychological, health, and employment prospects post-school. The project will inform the development of intervention programs for young people and maximise their overall adjustment and well-being several years later.Read moreRead less
The Great Exhibitions and their Lost Indigenous Objects . This project will rediscover the Australian Indigenous objects sent overseas to the Great Exhibitions of the nineteenth and early twentieth centuries. Such objects acted as powerful forms of cultural, political and economic display, and a form of imperial and colonial projection. It will excavate the hidden histories of Indigenous people involved in these events and the many objects lost to Australia. Through collaborative work at communi ....The Great Exhibitions and their Lost Indigenous Objects . This project will rediscover the Australian Indigenous objects sent overseas to the Great Exhibitions of the nineteenth and early twentieth centuries. Such objects acted as powerful forms of cultural, political and economic display, and a form of imperial and colonial projection. It will excavate the hidden histories of Indigenous people involved in these events and the many objects lost to Australia. Through collaborative work at community dialogues, the project will repatriate knowledge and remake connections between objects, museums, and Indigenous people. In doing so, it will bring contemporary Indigenous perspectives to global attention, generate new exhibition possibilities and influence international museum practice.Read moreRead less
Radicalisation, Counter-Radicalisation, and De-Radicalisation: Developing a New Understanding of Terrorism in the Australian Context. Concentrating on the unique drivers of extremism within Victoria (and Australia), the study will enhance counter terrorism stakeholders' understanding of domestic radicalization. This will assist in designing policies appropriate for Australian circumstances that can: 1. pre-empt, prevent and detect radicalisation without jeopardising social cohesion and 2. reduce ....Radicalisation, Counter-Radicalisation, and De-Radicalisation: Developing a New Understanding of Terrorism in the Australian Context. Concentrating on the unique drivers of extremism within Victoria (and Australia), the study will enhance counter terrorism stakeholders' understanding of domestic radicalization. This will assist in designing policies appropriate for Australian circumstances that can: 1. pre-empt, prevent and detect radicalisation without jeopardising social cohesion and 2. reduce Australia's reliance on overseas counter-radicalisation and de-radicalisation models, where practitioners confront different community dynamics. Working towards understanding what causes radicalization in Australia, the project offers to enhance national security and by addressing local circumstances carries the prospect of creating more cost-efficient counter terrorism practices.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882507
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
AustLit Phase Two: Research Infrastructure for Humanities and Education Researchers. The benefits of delivering a fully mature research and information facility to the education and research sectors and the general public will accrue over time by providing discovery and analysis opportunities to large numbers of enquirers. The capacity to reveal the wealth and diversity of a nation's cultural activities across its history is an inherent good and the resulting research activities will encourage a ....AustLit Phase Two: Research Infrastructure for Humanities and Education Researchers. The benefits of delivering a fully mature research and information facility to the education and research sectors and the general public will accrue over time by providing discovery and analysis opportunities to large numbers of enquirers. The capacity to reveal the wealth and diversity of a nation's cultural activities across its history is an inherent good and the resulting research activities will encourage a greater engagement with Australia's literary culture of the present and the past.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775619
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
AustLit: Phase Two - humanities research infrastructure development, augmentation and expansion. With ARC support, the university and library collaborators will deliver a unique national information service revealing the wealth of Australian's literary and cultural endeavours over time. Enquirers from across the research, education and library sectors will be able to access the results of decades of scholarship in Australian literary, theatre, critical and Indigenous culture. Senior and emerging ....AustLit: Phase Two - humanities research infrastructure development, augmentation and expansion. With ARC support, the university and library collaborators will deliver a unique national information service revealing the wealth of Australian's literary and cultural endeavours over time. Enquirers from across the research, education and library sectors will be able to access the results of decades of scholarship in Australian literary, theatre, critical and Indigenous culture. Senior and emerging researchers will be able to continue building AustLit over time, using the infrastructure as a source of existing information to interrogate, and as a repository for new data that can be analysed and enhanced as research in new areas is pursued. Read moreRead less