Solving The Jigsaw! Understanding Biological And Environmental Effects On ADHD Through Discordant Mononozygotic Twins
Funder
National Health and Medical Research Council
Funding Amount
$557,500.00
Summary
The recent Child and Adolescent component of the National Mental Health Survey identified Attention Deficit Hyperactivity Disorder(ADHD) as the most common behavioural problem among Australian children. Since 1991 our Australian Twin ADHD Project (ATAP) has developed as one of the world's largest programs on the genetics of ADHD, and in 2001 we published the first text on this topic. In this grant we turn the focus onto environmental influences with the question Why can one identical twin have A ....The recent Child and Adolescent component of the National Mental Health Survey identified Attention Deficit Hyperactivity Disorder(ADHD) as the most common behavioural problem among Australian children. Since 1991 our Australian Twin ADHD Project (ATAP) has developed as one of the world's largest programs on the genetics of ADHD, and in 2001 we published the first text on this topic. In this grant we turn the focus onto environmental influences with the question Why can one identical twin have ADHD, while the other twin has no difficulties? Using the unique resources of the Australian Twin Registry and the WA Twin Child Health Study, we shall work across the country to find over 100 identical twin pairs who are very different in ADHD. In this way, each ADHD affected twin has an unaffected 'control twin', offering a powerful means for comparing the two. Such a study is really only possible in Australia, as no other country has such twin resources for research. The questions we want to consider with these children include the following 1- Twins have a more difficult time before and at birth. To what extent do these problems contribute to differences between the twins? 2- Are there differences in specific aspects of brain functioning? 3- Is it that one twin grows out of their ADHD but the other does not? If so, what distinguishes the children? 4- What is it like growing up with a twin who has ADHD, when you have no difficulties yourself? 5- When one twin has ADHD symptoms, is the family more likely to seek help, as they can see how different this child is form the other twin? Obviously identical twins in wehich only one has ADHD are a very unique group. By covering all aspects of development, from brain functioning to service utilisation, the hope is that this study will provide invaluable insights into this common condition which will help all children and families where the diagnosis of ADHD has been made.Read moreRead less
Imaging The Brain Connectome In Typical And Atypical Development
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
My project will investigate how connections in the brain change during the transition from childhood to adolescence. Advanced neuroimaging techniques will be used to understand how different parts of the brain are connected to one another, and how this changes over time. I will examine typically developing children, as well as those with attention deficit hyperactivity disorder (ADHD) in order to understand how neuropsychiatric disorders affect brain development.
Attention Deficit Hyperactivity Disorder: Genes, Cognition And Brain Activity
Funder
National Health and Medical Research Council
Funding Amount
$428,602.00
Summary
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder of childhood that is marked by age-inappropriate levels of inattention and-or hyperactivity-impulsivity. The disorder appears genetic with a number of different genes likely contributing risk for ADHD. I will use a multi-modal (genetic, cognitive, neurochemical, physiological) approach to increase our understanding of the biological mechanisms leading from gene to disorder in ADHD.
The Genetics Of Cognitive Deficits In Attention Deficit Hyperactivity Disorder (ADHD)
Funder
National Health and Medical Research Council
Funding Amount
$675,512.00
Summary
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder of childhood that is marked by age-inappropriate levels of inattention and-or hyperactivity-impulsivity. The disorder appears genetic with a number of different genes likely contributing risk for ADHD. This project takes an innovative approach by asking whether there are different genetic profiles associated with children with ADHD who do or do not have neurocognitive deficits.
Imaging Genetics Of Attention Deficit Hyperactivity Disorder (ADHD)
Funder
National Health and Medical Research Council
Funding Amount
$321,767.00
Summary
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder of childhood that is marked by age-inappropriate levels of inattention and-or hyperactivity-impulsivity. The disorder appears genetic with a number of different genes likely contributing risk for ADHD. This project takes an innovative approach by asking how risk genes for ADHD influence the brain activity of children with ADHD when they pay attention
Impact Of A Sleep Intervention In Children With ADHD: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$384,230.00
Summary
Attention deficit hyperactivity disorder (ADHD) affects up to 7.5% of Australian children. Between 50 and 70% of parents also report sleep problems (eg night waking, insomnia) in their child with ADHD. Such sleep problems are associated with poorer child behaviour, concentration, and school attendance as well as poorer parent mental health and work attendance. This randomised controlled trial will determine whether treating sleep problems in children with ADHD can improve these outcomes.
Attention deficit hyperactivity disorde(ADHD) is the most prevalent mental disorder of childhood affecting around 7.5% of Australian school age children. The disorder is strongly genetic and causes significant impairments in academic functioning, family and peer relations with sufferers at increased risk for drug abuse. Identification and characterisation of rare mutations will enhance our knowledge of the neurobiology and advance the search for next generation drug treatments for the disorder.
ADHD Grown-up: Genetic And Environmental Determinants Of The Adult Outcomes Of Childhood ADHD And Comorbid Conditions
Funder
National Health and Medical Research Council
Funding Amount
$289,542.00
Summary
ADHD remains a controversial issue especially in adulthood. There are many related behavioural problems including substance abuse, anxiety, depression, and personality disorders. Australia is such a focus for twin research that many twin families have taken part in several studies of different aspects of mental health over the years. This grant allows us to link the various datasets to create a unique longitudinal genetic resource and to examine the longterm outcomes.
Goal-directed Behaviour In Adolescent ADHD: Neural Connectivity And It’s Significance For Clinical Translation
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Impaired goal-directed decision-making leads to significant difficulties in adolescent attention deficit hyperactivity disorder (ADHD). This research will use novel imaging techniques to study individual-level impairments in brain connectivity in decision making circuits and the effects of common ADHD medications. As these medications are currently prescribed by trial and error, identifying specific connectivity brain signatures will make major contributions to personalised treatment selection.
Genetic Influence On Cognitive Function And Medication Response In Attention Deficit Hyperactivity Disorder (ADHD).
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
ADHD is one of the most common child mental health conditions, with cognitive deficits that impact everyday functioning, educational and social outcomes. Not all children with ADHD achieve equal benefit from medication. The disorder appears to be genetic with many genes contributing a small risk for the disorder. This project asks how DNA variation influences ADHD brain function and how they respond to medication. This project is important to improve the clinical diagnosis and outcome for ADHD.