Transcriptional Regulation Of Gene Expression: Dietary Sialic Acid Interaction In Brain Cognitive Development
Funder
National Health and Medical Research Council
Funding Amount
$46,646.00
Summary
In 2004, 8.2% of Australian live births were preterm with poor long-term cognitive outcomes. Sialic acid (SA), a key component of both human milk oligosaccharides and neural tissues, plays a role in neuronal development. This study will examine the mechanisms of how dietary SA or active learning interacts with genes during brain development. It will benefit the neonatal care of all children, particularly those born premature and ultimately, the quality of life of many Australians.
A Cluster Randomised Trial To Test A Systems Based Collaborative For Type 2 Diabetes Among Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$1,855,936.00
Summary
Type 2 diabetes is a condition which contibutes significantly to Indigenous disability and premature death. Increasing numbers of Indigenous Australians are developing Type 2 diabetes. To date there has been limited research on systematic approaches to improving screening and managment outcomes for Type 2 diabetes. This important research will test the effectiveness of a systems based collaborative approach to improve health outcomes for people with Type 2 diabetes.
Perth Aboriginal Breast Feeding Study: Reasons For Not Breast Feeding And For The Early Cessation Of Breast Feeding.
Funder
National Health and Medical Research Council
Funding Amount
$207,237.00
Summary
Perth Aboriginal Breast Feeding Study : Reasons for not Breast Feeding and for the Early Cessation of Breast Feeding. Breastfeeding has many advantages for the nutrition and health of infants and mothers. Recent research has shown the importance of longitudinal studies of breast feeding and the importance of family support systems, especially the attitude of the baby's father. In urban Aboriginal families the rate of breast feeding is lower and the duration is shorter than for those living in ru ....Perth Aboriginal Breast Feeding Study : Reasons for not Breast Feeding and for the Early Cessation of Breast Feeding. Breastfeeding has many advantages for the nutrition and health of infants and mothers. Recent research has shown the importance of longitudinal studies of breast feeding and the importance of family support systems, especially the attitude of the baby's father. In urban Aboriginal families the rate of breast feeding is lower and the duration is shorter than for those living in rural areas. There have been no longitudinal studies exploring the factors involved in the initiation and the continuation of breast feeding by Aboriginal women. A sample of 440 Aboriginal women will be recruited from Perth maternity hospitals. After an initial interview the women will be followed up at monthly intervals to find out their progress with breast feeding. In addition a number of focus group discussions will explore attitudes of Aboriginal women and men to breast feeding. The outcome of the studies will be information to feed back to the community through Aboriginal organisations. It will provide the basis for specifically targeted health promotion programs to maintain and to improve breast feeding rates in the Aboriginal community.Read moreRead less
DCIS Management Since Publication Of Clinical Practice Recommendations: Surgeons' Practices And Women's Experiences
Funder
National Health and Medical Research Council
Funding Amount
$360,783.00
Summary
Ductal Carcinoma in Situ of the breast (DCIS) now represents 15% of all new cases of breast cancer. Although a benign disease, its diagnosis increases a woman's risk of developing invasive breast cancer and the goal of treatment is prevention of invasive disease. However the characteristics that predict this progression have not been clearly identified. Consequently women are confused about their diagnosis and both clinicians and women are faced with complex treatment decisions. The National Bre ....Ductal Carcinoma in Situ of the breast (DCIS) now represents 15% of all new cases of breast cancer. Although a benign disease, its diagnosis increases a woman's risk of developing invasive breast cancer and the goal of treatment is prevention of invasive disease. However the characteristics that predict this progression have not been clearly identified. Consequently women are confused about their diagnosis and both clinicians and women are faced with complex treatment decisions. The National Breast Cancer Centre (NBCC) published a set of eight clinical practice recommendations for the management of DCIS in September 2003 and a guide for consumers in 2004. Currently there is no information regarding how the treatment recommendations have been received by surgeons, the extent management of DCIS now follows these recommendations or the impact of the treatment recommendations on the medical experiences of women with DCIS. This project will fill this gap. The project aims to: 1. Examine the impact of clinical practice recommendations for the management of Ductal Carcinoma in Situ (DCIS) of the breast on clinical practice 2. Determine awareness of and attitudes towards the recommendations among surgeons treating DCIS and to examine the relationship between these attitudes and clinical practice 3. Examine women's experience of a DCIS diagnosis, their understanding of its prognosis and involvement in treatment decisions after release of a consumer guide in 2004 This research will determine whether the publication of the treatment recommendations in 2003 influenced the medical care women with DCIS recieve and identify the factors associated with surgeons and women that facilitate or prevent the uptake of these recommendations. This information will be used to develop strategies increase surgeons' adoption of the treatment recommendations in order to ensure that all women with DCIS have access to the best care possible.Read moreRead less