New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and manageme ....New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and management that can reduce risk and improve patient survival.Read moreRead less
Reducing The Greatest Uncertainty In Radiotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$594,197.00
Summary
The weakest link in radiotherapy is defining treatment volumes (contouring). Lack of accuracy and consistency in clinical trial contouring has been shown to result in reduced patient outcomes. Manual review of contouring is resource intensive, expensive and for advanced treatments unachievable in a timely fashion. We will assess an automated approach to contouring assessment using 4 clinical trial datasets, changing practice for future studies and enabling consistent assessment in the clinic.
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100210
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
In-vivo, high-resolution, whole animal imaging . The purchase of state-of-the-art live-animal imaging equipment for use by researchers at The Australian National University and The University of New South Wales. This equipment will aid the study of many aspects of normal biology and disease including cancer, inflammation, autoimmune diseases and blood vessel disorders.
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of dri ....Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of driving fluid flow thorough the lithosphere, mineralisation phenomena, their datasets and geometries, and dynamic aspects of the processes driving mineral systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100087
Funder
Australian Research Council
Funding Amount
$1,100,000.00
Summary
Plasma-focused ion beam for nanoscale characterisation of materials. This project aims to enable research programmes in functional materials to characterise materials using xenon-plasma focused ion beam (FIB) instrumentation. The plasma FIB, with its fast milling speeds across large areas, will enable new three-dimensional imaging experiments and types of transmission electron microscopy samples. This will have applications in engineering, photovoltaics and environmental geosciences, which all n ....Plasma-focused ion beam for nanoscale characterisation of materials. This project aims to enable research programmes in functional materials to characterise materials using xenon-plasma focused ion beam (FIB) instrumentation. The plasma FIB, with its fast milling speeds across large areas, will enable new three-dimensional imaging experiments and types of transmission electron microscopy samples. This will have applications in engineering, photovoltaics and environmental geosciences, which all need to analyse materials on a nanometre scale.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100156
Funder
Australian Research Council
Funding Amount
$289,500.00
Summary
3D Two-Photon Nanoprinter for Advanced Multi-Functional Materials & Devices. The Nanoscribe Photonic Professional GT2 Two-Photon 3D Printer enables tailoring materials’ architecture at nanoscale. This results in unique optical, mechanical, electrical, chemical, biochemical, and acoustic properties enabling a wealth of cutting-edge research activities in variety of fields including mechanical/optical/electrical metamaterials, bioinspired hard/soft materials, biomaterials (e.g., structured cell-ti ....3D Two-Photon Nanoprinter for Advanced Multi-Functional Materials & Devices. The Nanoscribe Photonic Professional GT2 Two-Photon 3D Printer enables tailoring materials’ architecture at nanoscale. This results in unique optical, mechanical, electrical, chemical, biochemical, and acoustic properties enabling a wealth of cutting-edge research activities in variety of fields including mechanical/optical/electrical metamaterials, bioinspired hard/soft materials, biomaterials (e.g., structured cell-tissue interfaces), biomedical devices (implantable devices and drug-delivery systems), nanofluidics, and photonic crystals. In each of these fields, we will use GT2 to print variety of polymers, hydrogels, metals and ceramics, for example by printing polymer-derived nanoceramics that will be simultaneously strong and tough.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100160
Funder
Australian Research Council
Funding Amount
$297,463.00
Summary
Femtosecond laser micropyrolysis gas chromatograph-mass spectrometer. This project aims to build a femtosecond-laser, micropyrolysis gas-chromatographmass spectrometer. The facility will have the capability to selectively analyse very small petrographically-recognisable organic components, hence bridging the analytical gap between organic petrography and organic geochemistry. The project aims to understand the early evolution of life, the response of the biosphere to mass extinction, the migrati ....Femtosecond laser micropyrolysis gas chromatograph-mass spectrometer. This project aims to build a femtosecond-laser, micropyrolysis gas-chromatographmass spectrometer. The facility will have the capability to selectively analyse very small petrographically-recognisable organic components, hence bridging the analytical gap between organic petrography and organic geochemistry. The project aims to understand the early evolution of life, the response of the biosphere to mass extinction, the migration of fluids in petroleum reservoirs, the heterogeneity of organic matter in shale gas reservoirs, and the composition of macromolecules in biominerals and macerals. The facility will contribute to a broad range of Australia’s theoretical and applied problems in geoscience and geobiology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100063
Funder
Australian Research Council
Funding Amount
$1,900,000.00
Summary
Scanning Transmission Electron Microscope for Beam-Sensitive Materials. This project aims to establish a transmission electron microscopy facility for the high-throughput characterisation of delicate materials, at the atomic scale and a broad range of temperatures. Unique in Australia, this capability will enable the location and type of atoms critical to materials properties to be determined for materials as diverse as lithium-bearing minerals, next-generation solar cells and drug-delivery agen ....Scanning Transmission Electron Microscope for Beam-Sensitive Materials. This project aims to establish a transmission electron microscopy facility for the high-throughput characterisation of delicate materials, at the atomic scale and a broad range of temperatures. Unique in Australia, this capability will enable the location and type of atoms critical to materials properties to be determined for materials as diverse as lithium-bearing minerals, next-generation solar cells and drug-delivery agents. In this way it will foster the engineering of new materials for addressing current challenges in energy, environment, transport, health and manufacturing. This will be a national, open access facility for use by research institutions and industry, and for training the next generation of postgraduate students.Read moreRead less