Dynamic resilience and stability properties of marine systems: the importance of environment-engineer feedbacks in kelp forests. Kelp forests form complex habitats that support diverse, productive and economically important food-webs. This project will determine whether healthy kelp forests engineer their environment to make conditions more suitable for their continued recruitment and survivorship, thus increasing their stability and resilience in response to anthropogenic threats.
Identifying Rare Genetic Variants Conferring Susceptibility To Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$293,898.00
Summary
Recently there has been success in identifying common genetic variants that confer susceptibility to multiple sclerosis. The variants that have been discovered so far have modest effects on risk of disease, and only explain a small proportion of familial aggregation of disease. In this study we aim to identify rarer genetic variants that have stronger effects on risk of disease, using new statistical methods and new methods to sequence very large amounts of DNA.
Understanding And Ameliorating The Human Health Effects Of Exposure To Air Pollution: From Knowledge To Policy And Public Health Practice
Funder
National Health and Medical Research Council
Funding Amount
$2,584,848.00
Summary
Urban consolidation and sprawl, traffic congestion, mining, climate change, heating and cooling living environments, and power generation – these manifestations of modernity produce regular headlines. Air pollution and its effects on human health are the focus of much popular concern. This CRE will build an integrated research capacity in the field of air pollution and its effects on human health that will allow Australia to address these major challenges - now and in the future.
Energy Transitions, Air Pollution And Health In Australia
Funder
National Health and Medical Research Council
Funding Amount
$2,491,229.00
Summary
Emissions from burning biomass (including fossil fuels) are major features of our environment and are the 4th leading global risk factor for premature death. As countries shift their patterns of energy use in response to global warming, new challenges are emerging. Understanding this is crucial to our ability to maintain health and stability in uncertain times. This CRE will examine the health consequences of (1) fossil fuel combustion, (2) landscape fires and (3) alternatives to fossil fuels.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
Federalism and International Risk Management. The introduction of new quarantine disciplines with the World Trade Organisation agreements has given rise to tensions within the Australian Federation over the relationship between state and national quarantine measures. This project will review critically these developments in order to better understand and improve the process of risk assessment which is increasingly important after the Salmon case. The project will train a graduate student in ri ....Federalism and International Risk Management. The introduction of new quarantine disciplines with the World Trade Organisation agreements has given rise to tensions within the Australian Federation over the relationship between state and national quarantine measures. This project will review critically these developments in order to better understand and improve the process of risk assessment which is increasingly important after the Salmon case. The project will train a graduate student in risk assessment policy, produce several scholarly outputs and contribute to improved policy in an area of vital national importance.Read moreRead less
Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to ....Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to a broad suite of environmental perturbations (temperature, nutrients, contaminants), will generate stress-response data that can be incorporated alongside eukaryotic data in environmental assessments, greatly improving the ecological relevance and reliability of risk and vulnerability assessments.Read moreRead less
Maternal effects and sex allocation: an integrated approach. This project will produce research of a high international standard combining a number of key fields in evolution and ecology. The team we have assembled provides a link between Australian-based researchers and leading overseas theoreticians facilitating integration between evolutionary theory and empirical research on the unique Australian fauna. Furthermore, while climate change is identified as a priority area for research, Australi ....Maternal effects and sex allocation: an integrated approach. This project will produce research of a high international standard combining a number of key fields in evolution and ecology. The team we have assembled provides a link between Australian-based researchers and leading overseas theoreticians facilitating integration between evolutionary theory and empirical research on the unique Australian fauna. Furthermore, while climate change is identified as a priority area for research, Australia typically lacks the history of long-term phenological monitoring that is required to understand climate change impacts. This project takes an important step towards addressing this shortcoming.Read moreRead less
Epigenetic Biomarker Discovery For Cardiovascular Disease Risk Stratification Of Women Following Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$1,275,101.00
Summary
Those women whom have suffered from severe complications during pregnancy have an increased risk of developing heart disease. This increased risk may be due to epigenetic changes during pregnancy that alter the expression of specific genes. These epigenetic changes persist after birth and increase heart disease risk for these women. This project seeks to evaluate those epigenetic changes associated with severe pregnancy complications predicting heart disease in a large group of Australian women.
From developmental stability to organismic senility: Hox genes and telomere impact on life history evolution. Australia benefits from training researchers and technicians in new, break-through biotechnology and from applying this knowledge to relevant, cutting-edge questions in highly publicized research fields. This project contains both these ingredients. Our model species (a lizard) has a relatively high level of offspring malformations (ca 15%), which makes it much more likely to detect thei ....From developmental stability to organismic senility: Hox genes and telomere impact on life history evolution. Australia benefits from training researchers and technicians in new, break-through biotechnology and from applying this knowledge to relevant, cutting-edge questions in highly publicized research fields. This project contains both these ingredients. Our model species (a lizard) has a relatively high level of offspring malformations (ca 15%), which makes it much more likely to detect their underlying genetic mechanism. Furthermore, we can also assess how these animals survive and reproduce in relation to how quickly they age, which can be measured by assessing the shortening of telomeres per unit time. Thus, this collaboration provides an opportunity to train Australian researchers and in that process generate very high profile research.Read moreRead less