Zonal Expression And Persistence Of RAAV Vectors Within The Hepatic Lobule: Towards Gene Therapy For Metabolic Disease.
Funder
National Health and Medical Research Council
Funding Amount
$84,173.00
Summary
In its most severe form the urea cycle disorder OTC deficiency has a high risk of death. Current therapy is liver transplantation which has significant shortcomings including lack of donor organs. Therefore, a need to provide a safer and more effective alternative treatment exists. Liver directed gene therapy with adeno-associated virus (AAV) can potentially provide this treatment. This project aims to optimise AAV2-8 vectors for liver gene therapy in the treatment of metabolic liver disease.
An Analysis Of Maternal Health Services For Remote Dwelling Aboriginal Women And Infants From The Top End Of Australia
Funder
National Health and Medical Research Council
Funding Amount
$153,222.00
Summary
Indigenous women demand changes in healthcare services. This project occurs at the instigation of women from two Top End remote communities. It will analyse the organization and delivery of maternal health care services for women and infants from Maningrida and Wadeye and identify how services could be improved. This project will help develop strategies for maternal health service redesign and assist in improving health outcomes for Indigenous mothers and infants from these remote communities.