Generating multi-component scaffolding to influence the differentiation of embryonic stem cells. Nervous system diseases are debilitating and will develop in over 50 per cent of people at some time in their life. This project will develop strategies so that stem cells can be utilised to encourage brain repair for the treatment of Parkinson's disease. The technology developed will also be of benefit for the treatment of other nervous system disorders.
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Development of Model Systems to Investigate Blood Hydrodynamic Parameters Affecting Blood Cell Function: An Interdisciplinary Approach. National benefit will come through this research contributing to a better understanding of blood flow biology and pathology, both of which are of particular relevance to the aging Australian population. This benefit is well aligned with the 2008 National research priority 2: Promoting and Maintaining Good Health; Priority Goal 3. Preventative Health. The synthes ....Development of Model Systems to Investigate Blood Hydrodynamic Parameters Affecting Blood Cell Function: An Interdisciplinary Approach. National benefit will come through this research contributing to a better understanding of blood flow biology and pathology, both of which are of particular relevance to the aging Australian population. This benefit is well aligned with the 2008 National research priority 2: Promoting and Maintaining Good Health; Priority Goal 3. Preventative Health. The synthesis of both extensive expertise in platelet/cardiovascular research and bioengineering/rheology should provide a substantial platform from which fundamental new discoveries in this niche area can be made. The development of novel platelet analysis tools arising from this work may also ultimately lead to new intellectual property and attract industry based funding.Read moreRead less
Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preven ....Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preventative health perspective, the investigation of platelet calcium signalling will greatly accelerate the development of new pharmaceuticals to tackle acute and chronic cardiovascular diseases, such as stroke, heart attack and artherosclerosis. Read moreRead less
Engineering stable, efficient perovskite solar cells. This project aims to address and resolve a critical issue facing perovskite solar cells which have enormous potential as a future technology for the large-scale generation of cheap, clean electricity: their instability under actual operating conditions. The project is expected to make significant fundamental advances in compositional, structural and interface engineering. This project will benefit the environment by paving the way for the wi ....Engineering stable, efficient perovskite solar cells. This project aims to address and resolve a critical issue facing perovskite solar cells which have enormous potential as a future technology for the large-scale generation of cheap, clean electricity: their instability under actual operating conditions. The project is expected to make significant fundamental advances in compositional, structural and interface engineering. This project will benefit the environment by paving the way for the widespread adoption of cheaper and more efficient solar cells.Read moreRead less
Nanophotonics for strong absorption in extremely thin solar cells: moving beyond silicon. This project will lead to the development of extremely thin solar cells made of novel low-cost materials, which would likely reduce the cost of photovoltaic technology. If the cost of photovoltaics was sufficiently low then it could have a major impact on reducing greenhouse gas emissions and pollution in Australia and worldwide.
Transparent metal oxides, a window of opportunity for silicon solar cells. This project aims to develop novel silicon heterojunction solar cells based on transparent conductive metal oxides (TCOs). Thin layers of zinc, gallium and molybdenum oxides present negligible absorption losses, which leads to a high output current. The project will optimise them as surface passivating layers, to achieve a high output voltage. TCOs can also provide good lateral conductivity, to boost the fill factor. The ....Transparent metal oxides, a window of opportunity for silicon solar cells. This project aims to develop novel silicon heterojunction solar cells based on transparent conductive metal oxides (TCOs). Thin layers of zinc, gallium and molybdenum oxides present negligible absorption losses, which leads to a high output current. The project will optimise them as surface passivating layers, to achieve a high output voltage. TCOs can also provide good lateral conductivity, to boost the fill factor. The research proposes to create insight into the physical mechanisms of selective contacts for electrons and holes, paving the way for a range of innovative solar cell concepts. Transparent metal oxides open new windows of opportunity to increase the conversion efficiency of silicon solar cells using simpler fabrication processes.Read moreRead less
Doped metal perovskites for electrocatalysis. This project aims to discover and design perovskite metal-oxide electrocatalyst materials and develop electrocatalytic methods for efficiently driving the oxygen evolution reaction and the oxygen reduction reaction. These are the two most crucial reactions in sustainable energy cycles involving water, hydrogen and oxygen. The project’s anticipated advances in electrocatalysis efficiency for these two reactions will benefit sustainable energy technolo ....Doped metal perovskites for electrocatalysis. This project aims to discover and design perovskite metal-oxide electrocatalyst materials and develop electrocatalytic methods for efficiently driving the oxygen evolution reaction and the oxygen reduction reaction. These are the two most crucial reactions in sustainable energy cycles involving water, hydrogen and oxygen. The project’s anticipated advances in electrocatalysis efficiency for these two reactions will benefit sustainable energy technologies such as fuel cells, metal air batteries and water splitting.Read moreRead less
Nanowire quantum well infrared photodetectors. This project aims to demonstrate semiconductor nanowire based quantum well infrared (IR) photodetectors for applications in chemical analysis, remote sensing, thermal imaging, environmental monitoring, space ranging and communications. By utilising one-dimensional nanowire detector architecture, the project expects that improved sensitivity, functionality and reduced cost can be achieved surpassing the performance of current IR technologies. This pr ....Nanowire quantum well infrared photodetectors. This project aims to demonstrate semiconductor nanowire based quantum well infrared (IR) photodetectors for applications in chemical analysis, remote sensing, thermal imaging, environmental monitoring, space ranging and communications. By utilising one-dimensional nanowire detector architecture, the project expects that improved sensitivity, functionality and reduced cost can be achieved surpassing the performance of current IR technologies. This project will pave the way for a new research and development platform for next generation large scale, low cost, high performance IR systems with commercialisation opportunities accessible to both high-end defence sectors and broader civilian industries.Read moreRead less
Fundamental electronic transport in emerging one-dimensional nanoelectronic devices. This project aims to understand the mechanisms limiting electronic transport in one-dimensional nanoelectronic devices and structures at temperatures relevant for practical device operation. One-dimensional nanoelectronic devices will be the building blocks of future technological innovation. This project will use a characterisation approach, numerical modelling and simulation, which promise to deliver knowledge ....Fundamental electronic transport in emerging one-dimensional nanoelectronic devices. This project aims to understand the mechanisms limiting electronic transport in one-dimensional nanoelectronic devices and structures at temperatures relevant for practical device operation. One-dimensional nanoelectronic devices will be the building blocks of future technological innovation. This project will use a characterisation approach, numerical modelling and simulation, which promise to deliver knowledge and analysis tools for ongoing innovation and optimisation in semiconductor nanoelectronics.Read moreRead less