Restoration Of Cognitive Deficits Induced By Diabetes Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$261,251.00
Summary
Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's intern ....Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's international standing in the field of advanced medical imaging and have the potential to be commercialised within the Australian biotechnology sector. During the project, research students will receive high quality multidisciplinary training ensuring the supply of personnel with high-level technical expertise into the future.Read moreRead less
Dementia Associated To Diabetes: Prevention Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$719,770.00
Summary
Diabetic insulin resistance is reported to induce cognitive decline and dementia. An accumulating body of evidence suggest that compromised integrity of neurovascular unit and following changes in cerebral lipid homeostasis may be centrally involved in the neurodegeneration and cognitive deficits. Therefore, the project aims to prevent the insulin resistance-associated cognitive impairment by modulating the integrity of cerebrovasculature and lipid homeostasis.
The Effect Of Selected Nutraceuticals On Brain Blood Vessels And Memory.
Funder
National Health and Medical Research Council
Funding Amount
$445,206.00
Summary
The human brain receives 1000L of blood per day, distributed through minute vessels called capillaries. The integrity and function of brain capillaries is compromised with aging and this may contribute to memory disturbances. Our laboratory has identified several naturally occurring compounds that prevent age-associated defects of brain capillaries. The primary aim of this project is to explore if these agents are beneficial for restoring brain capillary function and memory.
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less