An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.
Effects Of Fast Versus Slow Weight Loss On Fat, Muscle And Bone In Postmenopausal Women
Funder
National Health and Medical Research Council
Funding Amount
$316,450.00
Summary
Very low energy diets (VLED) are increasingly used to treat obesity. Of concern is the fact that VLED induce adaptive responses that can inhibit loss of, and promote regain of, abdominal fat while decreasing lean body mass, muscle strength and bone density. This project will therefore determine whether VLEDs could have negative effects on body composition that increase the risk of metabolic disease, sarcopenia or osteoporosis, and if so, what mechanisms are involved.
GENETIC PREDICTION OF FRACTURE IN A RISK-STRATIFIED POPULATION
Funder
National Health and Medical Research Council
Funding Amount
$363,000.00
Summary
Osteoporosis is a condition characterised by excessive bone loss and impaired bone quality, which ultimately results in fracture with minimal trauma. Osteoporosis affects 27% of women and 11% of men aged 60 years or above in the community, and costs Australia around $7 billion each year. Individuals with low bone mineral density (BMD) have a significantly higher risk of fracture than those with normal BMD. In the long-term (14-year) Dubbo Osteoporosis Epidemiology Study, more than half of indivi ....Osteoporosis is a condition characterised by excessive bone loss and impaired bone quality, which ultimately results in fracture with minimal trauma. Osteoporosis affects 27% of women and 11% of men aged 60 years or above in the community, and costs Australia around $7 billion each year. Individuals with low bone mineral density (BMD) have a significantly higher risk of fracture than those with normal BMD. In the long-term (14-year) Dubbo Osteoporosis Epidemiology Study, more than half of individuals with osteoporosis (e.g., low BMD) did not sustain a fracture, while approximately 60% of fracture cases had BMD above the high risk levels. Thus, BMD alone is not a good discriminant of fracture versus non-fracture cases. It is widely known that the liability to fracture is determined in part by genes. Previous studies, including from our group, have suggested a number of candidate genes that are associated with fracture risk. The fundamental issue that this study is concerned is that how and whether genetic markers could be used to facilitate case finding. It is proposed that common variations of certain genes are associated with fracture risk independent of BMD. That is, they can identify individuals at relatively high and low fracture risk after stratification for BMD. Hence, some markers may identify those individuals likely (and unlikely) to fracture even with low (osteoporotic) BMD. Similarly, some, possibly the same, markers may identify individuals at high risk of fracture despite relatively good (ie non-osteoporotic) BMD. It is further proposed that no single gene will achieve this outcome, but rather a small set of such gene polymorphisms will provide clinically useful risk information. This effect is entirely analogous to the use of clinical risk indicators (eg, age, weight, sex, family history, etc) to assess the risk of future fracture.Read moreRead less
Myeloma Plasma Cell Dormancy - 'Eradicating The Sleeping Giant'
Funder
National Health and Medical Research Council
Funding Amount
$834,428.00
Summary
Multiple myeloma is a fatal cancer that develops in the skeleton. Current therapies are initially effective, but patients develop resistance and the disease returns. This makes the search for drugs to overcome resistance a priority. Myeloma cells can hide in bone in a dormant state where they are insensitive to chemotherapy. We have identified new drug targets in dormant cells. We are investigating whether these new targets can be used eradicate myeloma cells and cure the disease.
Industrial Transformation Research Hubs - Grant ID: IH130200004
Funder
Australian Research Council
Funding Amount
$3,966,350.00
Summary
ARC Research Hub for transforming the mining value chain. ARC Research Hub for transforming the mining value chain. This Research Hub aims to transform the mining value chain to make significant improvements to industry practices through enhancing ore deposit discovery, mineral processing, and environmental management of ores and waste materials. The Hub will bring together a team of world-class researchers, industry partners and research facilities to develop end-user driven solutions to improv ....ARC Research Hub for transforming the mining value chain. ARC Research Hub for transforming the mining value chain. This Research Hub aims to transform the mining value chain to make significant improvements to industry practices through enhancing ore deposit discovery, mineral processing, and environmental management of ores and waste materials. The Hub will bring together a team of world-class researchers, industry partners and research facilities to develop end-user driven solutions to improve profitability and productivity in Australia’s mining industry.Read moreRead less
Fibre-reinforced composites: Single-crystal mullite fibres from topaz. The project aims to develop the means of fabricating single-crystal mullite fibres from topaz that are suitable for reinforcement of metal and ceramic matrix composites. Single-crystal mullite is the most sought after fibrous additive, but is not available commercially. It is expected to attract an immediate clientele in laboratories and companies servicing the aviation industry and the military. This will allow large depos ....Fibre-reinforced composites: Single-crystal mullite fibres from topaz. The project aims to develop the means of fabricating single-crystal mullite fibres from topaz that are suitable for reinforcement of metal and ceramic matrix composites. Single-crystal mullite is the most sought after fibrous additive, but is not available commercially. It is expected to attract an immediate clientele in laboratories and companies servicing the aviation industry and the military. This will allow large deposit of topaz in Torrington, NSW to be used to develop a high-value niche product (fibres) and a large-volume, low-value product (fluoride). This will provide significant economic and environmental benefits and it addresses the research priorities - Resources and Advanced Manufacturing.Read moreRead less
Enhanced recovery and concentration of cenospheres from fly ash. The purpose of this project is to investigate the recovery of valuable particles, referred to as cenospheres, from the fly ash waste of coal fired power stations. An understanding of the complex gravitational settling behaviour of fly ash suspensions in inclined channels will lead to a new technology for recovering and concentrating the particles.
Long-term acid rock and tailings drainage mitigation through source control. Effective long-term management of acid rock drainage (ARD) from sulfidic mine wastes in current, exhausted and legacy mine sites is of critical importance to communities and for sustainable mining. An optimised geochemical and microbial multi-barrier approach to long-term reduction of ARD to environmentally acceptable rates will be developed by this project.
This study aims to elucidate central pathways which can be manipulated to drive the storage of excess energy away from fat and instead directing it into the production of bone mass. Having identified leptin-responsive NPY neurons as important in the control of energy partitioning, we will focus on manipulating these neurons in the hypothalamus using innovative technology to alter body composition. This research has the potential to result in novel treatments for obesity and osteoporosis.