Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Design and Optimisation of Novel Enthalpy Heat Exchangers. This project deals with the thermal design and optimisation of a novel type of latent energy heat exchanger. This new heat exchanger overcomes the practical implementation problems of previous latent energy heat exchangers such as heat-wheels. The main application of this innovative heat exchanger will be to improve the capacity and efficiency of air conditioning systems. As the new heat exchanger is very compact it will be ideally sui ....Design and Optimisation of Novel Enthalpy Heat Exchangers. This project deals with the thermal design and optimisation of a novel type of latent energy heat exchanger. This new heat exchanger overcomes the practical implementation problems of previous latent energy heat exchangers such as heat-wheels. The main application of this innovative heat exchanger will be to improve the capacity and efficiency of air conditioning systems. As the new heat exchanger is very compact it will be ideally suited for integration with air conditioning coils. Existing latent heat wheels are very bulky and are difficult to integrate into standard air conditioner installations.Read moreRead less
GENETIC PREDICTION OF FRACTURE IN A RISK-STRATIFIED POPULATION
Funder
National Health and Medical Research Council
Funding Amount
$363,000.00
Summary
Osteoporosis is a condition characterised by excessive bone loss and impaired bone quality, which ultimately results in fracture with minimal trauma. Osteoporosis affects 27% of women and 11% of men aged 60 years or above in the community, and costs Australia around $7 billion each year. Individuals with low bone mineral density (BMD) have a significantly higher risk of fracture than those with normal BMD. In the long-term (14-year) Dubbo Osteoporosis Epidemiology Study, more than half of indivi ....Osteoporosis is a condition characterised by excessive bone loss and impaired bone quality, which ultimately results in fracture with minimal trauma. Osteoporosis affects 27% of women and 11% of men aged 60 years or above in the community, and costs Australia around $7 billion each year. Individuals with low bone mineral density (BMD) have a significantly higher risk of fracture than those with normal BMD. In the long-term (14-year) Dubbo Osteoporosis Epidemiology Study, more than half of individuals with osteoporosis (e.g., low BMD) did not sustain a fracture, while approximately 60% of fracture cases had BMD above the high risk levels. Thus, BMD alone is not a good discriminant of fracture versus non-fracture cases. It is widely known that the liability to fracture is determined in part by genes. Previous studies, including from our group, have suggested a number of candidate genes that are associated with fracture risk. The fundamental issue that this study is concerned is that how and whether genetic markers could be used to facilitate case finding. It is proposed that common variations of certain genes are associated with fracture risk independent of BMD. That is, they can identify individuals at relatively high and low fracture risk after stratification for BMD. Hence, some markers may identify those individuals likely (and unlikely) to fracture even with low (osteoporotic) BMD. Similarly, some, possibly the same, markers may identify individuals at high risk of fracture despite relatively good (ie non-osteoporotic) BMD. It is further proposed that no single gene will achieve this outcome, but rather a small set of such gene polymorphisms will provide clinically useful risk information. This effect is entirely analogous to the use of clinical risk indicators (eg, age, weight, sex, family history, etc) to assess the risk of future fracture.Read moreRead less
Myeloma Plasma Cell Dormancy - 'Eradicating The Sleeping Giant'
Funder
National Health and Medical Research Council
Funding Amount
$834,428.00
Summary
Multiple myeloma is a fatal cancer that develops in the skeleton. Current therapies are initially effective, but patients develop resistance and the disease returns. This makes the search for drugs to overcome resistance a priority. Myeloma cells can hide in bone in a dormant state where they are insensitive to chemotherapy. We have identified new drug targets in dormant cells. We are investigating whether these new targets can be used eradicate myeloma cells and cure the disease.
Impact Of An Ivermectin Mass Drug Administration Program Against Endemic Scabies And Strongyloidiasis
Funder
National Health and Medical Research Council
Funding Amount
$1,289,786.00
Summary
Overseas studies suggest sustainable and long term benefits can be obtained through the use of ivermectin in mass drug administration programs to control parasitic infections. Our study will be a critical first step in establishing if such a program can be successful in a remote Indigenous community setting, where the disease burden from scabies and strongyloidiasis (threadworm infections) is very high.
The use of numerical and experimental techniques to develop energy efficient open refrigerated display cabinets. This project will provide knowledge for Australian industry to develop new energy efficient refrigerated display cabinets, putting Australia in the forefront of commercial refrigeration display cabinet technologies. This will have a significant impact on sustainability of our environment and will assist Australia to meet present and future international climate obligations by contrib ....The use of numerical and experimental techniques to develop energy efficient open refrigerated display cabinets. This project will provide knowledge for Australian industry to develop new energy efficient refrigerated display cabinets, putting Australia in the forefront of commercial refrigeration display cabinet technologies. This will have a significant impact on sustainability of our environment and will assist Australia to meet present and future international climate obligations by contributing to the reduction of greenhouse emissions. The Government has already introduced new MEPS levels, and are planning to increase these to more stringent levels in 2007. The development of the techniques proposed in this application will be essential for manufacturers if they are to economically meet these MEPS level requirements. Read moreRead less
Heat Transfer Enhancement Techniques for Air Conditioning and Refrigeration Equipment. The proposed Project will make significant contribution towards the both fundamental understanding of heat transfer enhancement using dimpled surfaces and the design of heat exchangers and, in particular to the application of dimpled surfaces in air conditioning and refrigeration industries. Unlike the previous CFD studies which have been made on the assumptions that the flow is steady and decoupled from the ....Heat Transfer Enhancement Techniques for Air Conditioning and Refrigeration Equipment. The proposed Project will make significant contribution towards the both fundamental understanding of heat transfer enhancement using dimpled surfaces and the design of heat exchangers and, in particular to the application of dimpled surfaces in air conditioning and refrigeration industries. Unlike the previous CFD studies which have been made on the assumptions that the flow is steady and decoupled from the heat transfer calculations in this Project the fully coupled problem will be solved, in which unsteady flows are allowed to occur over a dimpled surfaces. As a result we will be able to more accurately determine the resultant effects on the pressure drop and heat transfer. Read moreRead less
Stress During Pregnancy And The Developmental Origins Of Renal Disease In Aboriginal Australians
Funder
National Health and Medical Research Council
Funding Amount
$866,044.00
Summary
There is an epidemic of renal failure in Aboriginal people who also have high rates of premature birth of small babies. This project aims to understand the causes of kidney failure in Aboriginal people through testing if stress during pregnancy leads to the birth of preterm, small babies with small poorly formed kidneys that lead to kidney failure in later life. The effect of stressors impacting on pregnant women including infections, exposure to smoking and social stressors will be examined.
Analysis, simulation, fabrication and characterization of reliable, robust and scalable compact cooling elements based on semiconductor nanostructures. Modern electronic, microelectronic and optoelectronic devices generally work better when they are cooler. We aim to develop a semiconductor nanostructure cooling element which directly integrates into existing devices. The solid-state cooling element will be reliable, robust, scalable and operate in any orientation. The basis of operation is ....Analysis, simulation, fabrication and characterization of reliable, robust and scalable compact cooling elements based on semiconductor nanostructures. Modern electronic, microelectronic and optoelectronic devices generally work better when they are cooler. We aim to develop a semiconductor nanostructure cooling element which directly integrates into existing devices. The solid-state cooling element will be reliable, robust, scalable and operate in any orientation. The basis of operation is thermionic emission - electrons are the working fluid. Our project combines (1) analysis and simulation, (2) fabrication of nanostructures and (3) experimental test-benching using optical and electrical methods. The outcome of this research has the potential to revolutionize cooling of modern electronic and photonic systems, from computer motherboards to mobile phones.Read moreRead less
Novel methods for enhancing room temperature figure of merit of thermoelectric/thermionic materials for refrigeration applications. With global warming and an increased awareness of climate change, devices such as thermoelectric modules can be part of the solution, particularly if their relative power and efficiency can be increased. The aim of this project is to bring together theoreticians, experimentalists, materials scientists, and industrial partners with complementary expertise to develop ....Novel methods for enhancing room temperature figure of merit of thermoelectric/thermionic materials for refrigeration applications. With global warming and an increased awareness of climate change, devices such as thermoelectric modules can be part of the solution, particularly if their relative power and efficiency can be increased. The aim of this project is to bring together theoreticians, experimentalists, materials scientists, and industrial partners with complementary expertise to develop new techniques and methods for fabricating novel thermoelectric/thermionic materials with high figure of merit, ZT, for solid state refrigeration applications. The success of the project will lead to a 3 to 5 fold increase in the market share of thermoelectric cooler and will have a significant impact on the Australian economy and reduce greenhouse emissions and global warming. Read moreRead less