Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead ....Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead to a better understanding of the geological record of greenhouse-icehouse change. Knowledge of the nature of this change in the past is critical to predicting how our climate is going to behave in the future.Read moreRead less
MILLENIAL-SCALE INSTABILITY OF SEA LEVEL AND THE CLIMATE SYSTEM: NEW ANALYSIS OF CORAL TERRACES IN PAPUA NEW GUINEA. Northern hemisphere climates switched repeatedly and abruptly between cold and warm states during the ice ages. This unexplained finding poses uncertainties about future climate. The exact chronology of past sea level and climatic changes is a key to the problem: this project aims to establish precise chronology through re-analysis of coral terraces at Huon Peninsula, PNG. New U-s ....MILLENIAL-SCALE INSTABILITY OF SEA LEVEL AND THE CLIMATE SYSTEM: NEW ANALYSIS OF CORAL TERRACES IN PAPUA NEW GUINEA. Northern hemisphere climates switched repeatedly and abruptly between cold and warm states during the ice ages. This unexplained finding poses uncertainties about future climate. The exact chronology of past sea level and climatic changes is a key to the problem: this project aims to establish precise chronology through re-analysis of coral terraces at Huon Peninsula, PNG. New U-series dating methods will give an accurately-timed record of sea level changes, which will be tightly locked to marine-sediment records of climatic change, by using sharp changes in atmospheric radiocarbon as universal marker horizons.Read moreRead less
Apoptosis And Stem Cells In Cancer Development And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$22,852,198.00
Summary
To improve cancer therapy, we are studying two cancer hallmarks: enhanced cell survival and stem cell-like behaviour. As we discovered, cell death is often blocked in cancer cells. Hence, we are attempting to develop drugs that flip the natural ‘cell death switch’. Stem cells are rare cells that generate entire tissues, as we showed for the breast. Certain cancers may be driven by ‘rogue’ stem cells. If so, eradication of these rare cells within the bulk tumour may require novel therapies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
Read moreRead less
TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.
Alpha-2-Macroglobulin And The Transport And Uptake Of The Hormone, Hepcidin
Funder
National Health and Medical Research Council
Funding Amount
$533,541.00
Summary
Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.
Environmental Evolution of the Willandra Lakes World Heritage Area. The Willandra Lakes World Heritage Area ranks as the most significant area for documenting Australia TMs unique cultural and environmental history. Parts of this remarkable archive are being lost through erosion. This project is the basis for a strategic research alliance between the custodians and managers of the area and leading Australian research institutions to build a picture of the continent TMs human and environmental hi ....Environmental Evolution of the Willandra Lakes World Heritage Area. The Willandra Lakes World Heritage Area ranks as the most significant area for documenting Australia TMs unique cultural and environmental history. Parts of this remarkable archive are being lost through erosion. This project is the basis for a strategic research alliance between the custodians and managers of the area and leading Australian research institutions to build a picture of the continent TMs human and environmental history before this evidence is irretrievably lost. Lake Mungo is known to Australians as the site of the world TMs earliest cremation and a window into our remote past. We will provide novel insights into the evolution of the Australian landscape, its fragile environment and the history of its resilient inhabitants.Read moreRead less
Engineering planetary habitability: Earth’s first billion years. This project aims to establish the critical physical-chemical factors in the early surface environment and tectonic regime that supported early life and continuing habitability. Life was established on Earth within the first billion years of its 4.56-billion-year history. This project’s integrated geological and geochemical study will investigate this period’s rare sedimentary and volcanic record, including the oldest fossiliferous ....Engineering planetary habitability: Earth’s first billion years. This project aims to establish the critical physical-chemical factors in the early surface environment and tectonic regime that supported early life and continuing habitability. Life was established on Earth within the first billion years of its 4.56-billion-year history. This project’s integrated geological and geochemical study will investigate this period’s rare sedimentary and volcanic record, including the oldest fossiliferous sequences discovered recently, to show how the early Earth’s chemistry supported life and evolution. The project expects to enhance understanding of why life prospers on some habitable zone planets but not on others.Read moreRead less
Understanding The Acute And Cumulative Metabolic Effects Of Prolonged Sitting In Adults
Funder
National Health and Medical Research Council
Funding Amount
$416,597.00
Summary
Sedentary behaviour (sitting time) has been linked to an increased risk of chronic illnesses, including type 2 diabetes and obesity, but recent evidence suggests that light-intensity activity (non-exercise activities of daily living) is associated with reduced risk. These studies will examine whether breaking up sitting time with frequent short periods of activity can overcome the negative effects of prolonged sitting on blood glucose and blood fats in overweight older adults.
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less