Genomics For Combating Antimicrobial Resistant Bacterial Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$2,027,364.00
Summary
Applying genomics to bacterial pathogens is revolutionising the way we understand infectious diseases and antimicrobial resistance (AMR). There is a major opportunity to now bring the technology into routine clinical and public health practice. This research program will investigate and deliver the technology of pathogen genomics directly into public health disease surveillance, outbreak detection and the diagnosis and response to infectious diseases and AMR in hospitalised patients.
Understanding The Development And Spread Of Pan Resistance In Acinetobacter Baumannii
Funder
National Health and Medical Research Council
Funding Amount
$2,339,215.00
Summary
Resistance to all antibiotics available for treatment of bacterial infections is a cause for global concern (Word Health Organization, US Centres for Disease Control) as it also compromises therapies relying on antibiotics such as transplantation and cancer chemotherapy. Extensively antibiotic resistant Acinetobacter baumannii, mainly causes hospital-acquired infections. This project will seek to track different types of these bacteria as they repeatedly spread around the world.
Improving Reproductive Health Through Infectious Diseases Research
Funder
National Health and Medical Research Council
Funding Amount
$1,957,108.00
Summary
Infectious diseases that impact upon reproductive health remain a major problem worldwide. This proposal will examine human papillomavirus infection, the role of the human microbiota in a number of conditions (necrotising enterocolitis, bacterial vaginosis, and human papillomavirus infection), and antibiotic resistance in sexually transmitted infections. The knowledge generated will be used to improve diagnostics.
Systems-based Study, Intervention, Diagnosis And Control Of Gastrointestinal Parasites
Funder
National Health and Medical Research Council
Funding Amount
$2,538,220.00
Summary
Gastrointestinal parasites cause billions of infections and hundreds of thousand of deaths globally each year. Even in developed countries, these parasites remain an important public health risk, through the cost of their control, the acute impacts of infection and their contribution to post-infectious irritable bowel syndrome and chronic fatigue. My team employs cutting-edge methods to improve their diagnosis, surveillance, treatment and control.
Structural Role Of The Host Cytoskeleton During Invasion Of Intracellular Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
During infection by bacteria, the 'skeleton' of cells plays critical roles in sensing the invading germs and destroying them. To counteract this, bacteria have evolved strategies to hijack the cell skeleton to promote their own survival, and spread. This intriguing molecular arms race is continuously co-evolving. Understanding this process in great details will have the potential to design novel therapeutics to counteract bacterial and viral infections.
Leaving No One Behind: Community-driven Approaches To Eliminate HIV In Australia
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
Eliminating HIV from Australia is possible with effective HIV prevention methods like treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP). However there are inequities in our HIV response with declines of new infections in Australian-born men who have sex with men but not in overseas-born Australian men. This program uses crowdsourcing (sharing solutions from the community to eliminate HIV) and evaluates the value of the proposed solutions, to inform HIV policy.