Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing an ....Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing and reduced-order state observer, supported by lab/plant experiments, and collaborating with two industry partners from coal and steel industries. The project outcomes including codes, models and raceway control strategies can help promote Australian metallurgical coal's global markets and ultimately the Australian economy.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH200100005
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Australian Steel Innovation. The Hub’s overarching goal is to support the transition of Australia’s steel manufacturing industry to a more sustainable, competitive and resilient position based on the creation of new, higher value-added products and more advanced manufacturing processes. It anticipates delivering original, innovative research designed to enable a necessary technological shift in the supply chain through integrating advanced enabling technologies in large and ....ARC Research Hub for Australian Steel Innovation. The Hub’s overarching goal is to support the transition of Australia’s steel manufacturing industry to a more sustainable, competitive and resilient position based on the creation of new, higher value-added products and more advanced manufacturing processes. It anticipates delivering original, innovative research designed to enable a necessary technological shift in the supply chain through integrating advanced enabling technologies in large and small businesses, developing step-change performance in anti-corrosion treatments and coating lines, generating more functional and durable products, and increasing resource intensities. It expects to train a more skillful and diverse workforce that will be critical in achieving this transformation.Read moreRead less
New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry suppl ....New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry supply and sales network. This project seeks to identify and harness the key material-product attributes required to develop and implement new, lead-free alloy alternatives that meet health-compliance, production and commercial viability, that offer benefits across the industry network and health benefits to society.Read moreRead less
Mitochondrial Iron Overload And Friedreich's Ataxia: The Role Of Frataxin In Iron And Haem Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$285,990.00
Summary
Friedreich's ataxia (FA) is due to the lack of a protein known as frataxin. Recent studies using Baker's yeast have shown that the deletion of frataxin results in the accumulation of toxic iron in the mitochondrion. More recently, a variety of studies have shown that FA patients have iron loading within their cells. The iron build-up may cause severe damage. At present, the role of frataxin in mammalian mitochondrial iron metabolism is unknown. Our preliminary studies demonstrate that frataxin i ....Friedreich's ataxia (FA) is due to the lack of a protein known as frataxin. Recent studies using Baker's yeast have shown that the deletion of frataxin results in the accumulation of toxic iron in the mitochondrion. More recently, a variety of studies have shown that FA patients have iron loading within their cells. The iron build-up may cause severe damage. At present, the role of frataxin in mammalian mitochondrial iron metabolism is unknown. Our preliminary studies demonstrate that frataxin is down-regulated by either erythroid differentiation or the haem precursor protoporphyrin IX (Becker and Richardson, submitted). These data strongly suggest a role for frataxin in iron metabolism. In the present study we will continue to assess if frataxin plays a role in the way cells handle iron. Using a unique model of mitochondrial iron overload developed in my lab (Richardson et al. (1996) BLOOD 87:3477), we will extensively investigate the iron metabolism of the mitochondrion in order to determine the function of frataxin and its role in Friedreich's ataxia. In addition, we have developed a series of new drugs known as iron chelators that can enter the mitochondrion due to their high lipid solubility (Becker and Richardson 1999 J. Lab. Clin. Med. 134:510). These latter drugs are far more effective than the chelator currently used to treat iron overload, desferrioxamine (DFO). Indeed, our chelators have been designed to result in high iron chelation efficacy but low toxicity (see Becker and Richardson, 1999). This exciting research may be crucial in understanding the development of FA and in creating new therapies such as the use of iron chelators.Read moreRead less
Origin and impact of solute clustering in light alloys. This project is designed to provide a physical metallurgy platform for understanding and interpreting the role of clusters of micro-alloying elements in precipitation in light alloys and aiding new alloy development. Phase transformations play an important role in determining the mechanical properties of many engineering materials. Understanding the origin and impact of solute clustering in phase transformations is crucial for achieving unp ....Origin and impact of solute clustering in light alloys. This project is designed to provide a physical metallurgy platform for understanding and interpreting the role of clusters of micro-alloying elements in precipitation in light alloys and aiding new alloy development. Phase transformations play an important role in determining the mechanical properties of many engineering materials. Understanding the origin and impact of solute clustering in phase transformations is crucial for achieving unprecedented properties in these materials. This project plans to combine atomic-scale characterisation and multi-scale computation to reveal the geometry and energetics of solute clusters and cluster-assisted nucleation in light alloys based on aluminium and magnesium. Applications may include the development of stronger and less costly metallic materials for the aerospace, aircraft and automotive industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100071
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capabil ....In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capability and amongst the few available globally. Temperature is the single most important parameter in material processing. This facility will permit the assembled team to be among the first in the world to apply this technique to the development of new materials with superior processing performance in addition to enhanced behaviour in service.Read moreRead less
High performance cast magnesium alloys. Reducing the weight of cars, particularly their engines, enables substantial reductions in fuel consumption and greenhouse gas emissions. A new generation of magnesium alloys will be developed by this project for the manufacture of considerably lighter components with improved mechanical performance for powertrain and structural applications.
Development Of Iron Complexes For The Treatment Of FriedreichÍs Ataxia & The Role Of Frataxin In Iron Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$616,143.00
Summary
Friedreich's ataxia (FA) is a neuro- & cardio-degenerative disease where there is an accumulation of toxic iron (Fe) in the mitochondrion. Work from our current NHMRC grant showed iron plays a significant role in FA pathology In fact, the CIs dissected the mechanisms of mitochondrial iron-loading & have published 8 papers in high impact journals with 3 papers in PNAS USA in the last 2 yrs Understanding of this process has led to the design of rationalised drugs for FA This work in this Renewal c ....Friedreich's ataxia (FA) is a neuro- & cardio-degenerative disease where there is an accumulation of toxic iron (Fe) in the mitochondrion. Work from our current NHMRC grant showed iron plays a significant role in FA pathology In fact, the CIs dissected the mechanisms of mitochondrial iron-loading & have published 8 papers in high impact journals with 3 papers in PNAS USA in the last 2 yrs Understanding of this process has led to the design of rationalised drugs for FA This work in this Renewal could lead to novel therapies for FARead moreRead less
Unlocking the diverse property profile of ultra-lightweight magnesium alloys. This project aims to develop the theory behind why micro alloying contributes to the formation of surface film properties. The exemplar is a prototype Magnesium-Lithium (Mg-Li) base alloy, with high specific-strength and corrosion resistance. This project will lead to the development of a new processable ultra-lightweight, corrosion resistant Mg-Li alloy family that is stronger than the prototype alloy, and with, at le ....Unlocking the diverse property profile of ultra-lightweight magnesium alloys. This project aims to develop the theory behind why micro alloying contributes to the formation of surface film properties. The exemplar is a prototype Magnesium-Lithium (Mg-Li) base alloy, with high specific-strength and corrosion resistance. This project will lead to the development of a new processable ultra-lightweight, corrosion resistant Mg-Li alloy family that is stronger than the prototype alloy, and with, at least, comparable ductility and corrosion resistance. Not only will the outcomes of the work be a fundamental advance to the fields of metallurgy and corrosion science, they will lead to the identification of an optimised compositional window for creating our second generation Mg-Li alloy family capable of being manufactured into ultra-lightweight, corrosion resistant metal products.Read moreRead less
Examination Of The Molecular Pharmacology Of Anthracyclines Induced Via Their Interaction With Iron
Funder
National Health and Medical Research Council
Funding Amount
$618,401.00
Summary
Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and ....Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and haem synthesis. Hence, this effect probably contributes to the cytotoxic activity of anthracyclines on the heart. We showed that novel drugs developed in my lab that bind Fe called chelators show high activity in animals (DR4) and prevent anthracycline-mediated Fe accumulation in ferritin. Importantly, Fe chelators have been shown to inhibit anthracycline-mediated cardiotoxicity. Indeed, the clinically used cardioprotective agent, ICRF-187, is actually an Fe chelator (5, DR6). However, ICRF-187 is not totally successful in terms of its cardioprotective effects and can cause myelosuppression (5, DR6). While the clinically used chelator, desferrioxamine (DFO), can prevent anthracycline-mediated cardiotoxicity, its poor membrane permeability limits its effectiveness. Our chelators are highly permeable and overcome the disadvantages of DFO (DR4). Thus, they are vital to examine for preventing anthracycline-mediated cardiotoxicity. In this proposal we will examine the changes in Fe metabolism induced by anthracyclines and test the hypothesis that novel Fe chelators may prevent the cardiotoxicity of these agents. We also aim to be the first to assess if preparation of anthracyclines which cannot bind iron prevents their cardiotoxicity. This will be done by preparing metal complexes of these drugs which prevent Fe-binding eg. anthracycline-zinc complexes. These studies are important for the development of less cardiotoxic forms of these very useful anti-tumour agents.Read moreRead less