Discovery and characterisation of novel spider-venom peptides targeting the human sodium ion channel Nav1.7. Drugs that selectively block the human sodium ion channel Nav1.7 are likely to be powerful analgesics for treating a wide variety of pain conditions. However, it has proved difficult to obtain selective blockers of this channel. The aim of this project is to determine whether spider-venoms might provide a source of highly selective Nav1.7 blockers.
Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing an ....Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing and reduced-order state observer, supported by lab/plant experiments, and collaborating with two industry partners from coal and steel industries. The project outcomes including codes, models and raceway control strategies can help promote Australian metallurgical coal's global markets and ultimately the Australian economy.Read moreRead less
New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry suppl ....New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry supply and sales network. This project seeks to identify and harness the key material-product attributes required to develop and implement new, lead-free alloy alternatives that meet health-compliance, production and commercial viability, that offer benefits across the industry network and health benefits to society.Read moreRead less
Strategic assessment of research performance indicators. The use of quantitative measures of research performance in higher education sends powerful messages to those being evaluated, because the choice of measures signals what is considered most important. However, little critical assessment has been undertaken on the use of performance indicators or their impact on research practice. This project will create a knowledge base on performance measures - their validity, fairness, transparency and ....Strategic assessment of research performance indicators. The use of quantitative measures of research performance in higher education sends powerful messages to those being evaluated, because the choice of measures signals what is considered most important. However, little critical assessment has been undertaken on the use of performance indicators or their impact on research practice. This project will create a knowledge base on performance measures - their validity, fairness, transparency and impact on research, and the cost of implementation. By assessing an extensive range of measures, it will provide Australian science management and science policy makers with rigorous information on which to base informed judgements on their utilisation.Read moreRead less
Evaluating the impact of neuromusculoskeletal impairment on athletic performance. Sufficient physical activity is required for good health. Competitive sport is a culturally significant physical activity in Australia and the prospect of participating in fair competition is known to drive participation. In Paralympic sport, fair competition is enabled by classification, which aims to minimise the impact of impairments on competition outcome. Unfortunately classification methods are not evidence-b ....Evaluating the impact of neuromusculoskeletal impairment on athletic performance. Sufficient physical activity is required for good health. Competitive sport is a culturally significant physical activity in Australia and the prospect of participating in fair competition is known to drive participation. In Paralympic sport, fair competition is enabled by classification, which aims to minimise the impact of impairments on competition outcome. Unfortunately classification methods are not evidence-based, reducing confidence in the process and discouraging participation. This project will inform the development of the first evidence-based classification system, creating the possibility that, in the future, the prospect of truly fair competition may motivate sports participation among Australians, regardless of disability.Read moreRead less
Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed g ....Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed global public response to challenges posed by genome editing. Research will test the effects of the deliberative documentary on viewers, examining benefits of communicating complex issues via the work of the GCA. Other benefits include improving public trust in governance and advancing the Australian film industry.
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Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and aga ....Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and again make Australian TID the international benchmark. Results will highlight the role of TID practices in improving recreational participation and maximising, attracting, developing and retaining sport talent. This will result in improved use of sports limited TID funding by providing greater understanding of factors that influence elite selection and sport development.Read moreRead less
Australia's Nuclear Choices. Australia's nuclear choices will be made in the context of a challenging and fluid international strategic environment characterised in Australia's immediate region by heightened global concerns regarding such transnational dilemmas as terrorism, energy security and nuclear proliferation. This project, through exploring the nature, evolution and consequences of contemporary strategic, military and civil nuclear developments impacting on the international non-prolifer ....Australia's Nuclear Choices. Australia's nuclear choices will be made in the context of a challenging and fluid international strategic environment characterised in Australia's immediate region by heightened global concerns regarding such transnational dilemmas as terrorism, energy security and nuclear proliferation. This project, through exploring the nature, evolution and consequences of contemporary strategic, military and civil nuclear developments impacting on the international non-proliferation regime will enable Australian policy-makers to better calibrate the costs and benefits of potential policy changes across these strategic, regime and market realms of Australia's nuclear interests.Read moreRead less
Cover crops that decrease phosphorus (P) transport from agricultural soils by increasing the efficiency of P fertiliser application. The aim of this project is to develop cover crop practices for the heavily fertilised potato cropping soils of the Robertson district that will minimise erosion and runoff of water potentially rich in phosphorus (P), thereby resulting in significant improvements in the environmental management of this sensitive catchment area. The cover crops will: (i) improve infi ....Cover crops that decrease phosphorus (P) transport from agricultural soils by increasing the efficiency of P fertiliser application. The aim of this project is to develop cover crop practices for the heavily fertilised potato cropping soils of the Robertson district that will minimise erosion and runoff of water potentially rich in phosphorus (P), thereby resulting in significant improvements in the environmental management of this sensitive catchment area. The cover crops will: (i) improve infiltration, decrease erosion, and off-site transport of P; (ii)increase access to accumulated soil P, making it available to a subsequent potato crop, thus decreasing the P loading of the soil; and (iii) have a biofumigation effect that will reduce the use of soil fumigants.
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High performance cast magnesium alloys. Reducing the weight of cars, particularly their engines, enables substantial reductions in fuel consumption and greenhouse gas emissions. A new generation of magnesium alloys will be developed by this project for the manufacture of considerably lighter components with improved mechanical performance for powertrain and structural applications.