Bias and allostery at the calcium sensing receptor. This project aims to provide a mechanistic and dynamic picture of the structure, function and physiology of the human calcium sensing receptor (CaSR), which is critical for vertebrate life. By responding to chemicals in the body, it acts as a universal nutrient sensor to maintain extracellular calcium homeostasis and mediate biological functions, including neurotransmission, inflammation, digestion, blood pressure and development. However, it i ....Bias and allostery at the calcium sensing receptor. This project aims to provide a mechanistic and dynamic picture of the structure, function and physiology of the human calcium sensing receptor (CaSR), which is critical for vertebrate life. By responding to chemicals in the body, it acts as a universal nutrient sensor to maintain extracellular calcium homeostasis and mediate biological functions, including neurotransmission, inflammation, digestion, blood pressure and development. However, it is not known how this single receptor controls the actions of multiple ligands to mediate numerous functions. By elucidating the roles of the CaSR and its ligands, this project aims to better understand fundamental physiological processes.Read moreRead less
Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing an ....Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing and reduced-order state observer, supported by lab/plant experiments, and collaborating with two industry partners from coal and steel industries. The project outcomes including codes, models and raceway control strategies can help promote Australian metallurgical coal's global markets and ultimately the Australian economy.Read moreRead less
New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry suppl ....New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry supply and sales network. This project seeks to identify and harness the key material-product attributes required to develop and implement new, lead-free alloy alternatives that meet health-compliance, production and commercial viability, that offer benefits across the industry network and health benefits to society.Read moreRead less
Special Research Initiatives - Grant ID: SR180100005
Funder
Australian Research Council
Funding Amount
$1,225,000.00
Summary
Remediation of PFAS contaminated soil using soil washing and immobilisation. This project aims to assess the applicability of soil washing and immobilisation as cost-effective techniques for the remediation of per- and poly-fluroalkyl substance (PFAS) contaminated Australian soils. The project expects to establish the efficacy of the remediation of a range of PFASs, including many polyfluorinated precursors of perfluorinated, chemically-persistent legacy pollutants which are of concern. The proj ....Remediation of PFAS contaminated soil using soil washing and immobilisation. This project aims to assess the applicability of soil washing and immobilisation as cost-effective techniques for the remediation of per- and poly-fluroalkyl substance (PFAS) contaminated Australian soils. The project expects to establish the efficacy of the remediation of a range of PFASs, including many polyfluorinated precursors of perfluorinated, chemically-persistent legacy pollutants which are of concern. The project will provide a scientific basis for understanding the benefits and limitations associated with soil washing and immobilisation techniques and a more comprehensive understanding of future liabilities associated with formation of PFASs from precursors remaining in remediated soils. Collaboration with stakeholders will ensure benefits are captured both commercially and environmentally, as well as removing a potential and on-going health threat to communities exposed to these contaminants.Read moreRead less
Preparation and use of lignite-iron ore composite briquettes for ironmaking. Preparation and use of lignite-iron ore composite briquettes for ironmaking. This project aims to study the briquetting processes of fine powders, and the preparation and utilization of new brown coal (lignite)–iron ore composite briquettes in a blast furnace. Lignite is a low-cost and abundant resource, and could be used in an emerging carbon-iron ore composite briquette for low-cost ironmaking. This project will perfo ....Preparation and use of lignite-iron ore composite briquettes for ironmaking. Preparation and use of lignite-iron ore composite briquettes for ironmaking. This project aims to study the briquetting processes of fine powders, and the preparation and utilization of new brown coal (lignite)–iron ore composite briquettes in a blast furnace. Lignite is a low-cost and abundant resource, and could be used in an emerging carbon-iron ore composite briquette for low-cost ironmaking. This project will perform multi-scale numerical studies, supported by lab/industry-scale experiments, to produce models and control strategies. Anticipated outcomes include better design and control of briquette's preparation and utilization in ironmaking for further cost-cutting; a new market for brown coal; and a more competitive Australian economy.Read moreRead less
Oxytocin receptor PET ligands: imaging the love receptor’s engagement. This project aims to develop a positron emission tomography (PET) ligand for the oxytocin receptor. This novel platform is significant as it will allow the scientific community to answer questions about the role of the oxytocin receptor in the important process of social behaviour which underlies quality of life. This knowledge gap has remained unanswered for decades due to the lack of specific techniques to measure oxytocin ....Oxytocin receptor PET ligands: imaging the love receptor’s engagement. This project aims to develop a positron emission tomography (PET) ligand for the oxytocin receptor. This novel platform is significant as it will allow the scientific community to answer questions about the role of the oxytocin receptor in the important process of social behaviour which underlies quality of life. This knowledge gap has remained unanswered for decades due to the lack of specific techniques to measure oxytocin receptor engagement. It is also significant as it will equip Australian startup Kinoxis Therapeutics to progress their molecules to market, a process enabled by measuring oxytocin receptor engagement. Our dual expertise on the oxytocin receptor and PET ligand development uniquely situate us to generate this technology.Read moreRead less
Developing a novel carbon negative fertiliser . Food security is vital to support our growing population. However, our increasing reliance on intensive farming systems necessitates increased fertiliser use, leading to increased water pollution and soil degradation - threatening both the Australian environment and food security. Increasing carbon storage capacity by soil and decreasing fertiliser use are two of the primary pathways for restoring the bio-support capacity of soils and reducing farm ....Developing a novel carbon negative fertiliser . Food security is vital to support our growing population. However, our increasing reliance on intensive farming systems necessitates increased fertiliser use, leading to increased water pollution and soil degradation - threatening both the Australian environment and food security. Increasing carbon storage capacity by soil and decreasing fertiliser use are two of the primary pathways for restoring the bio-support capacity of soils and reducing farming footprints. This innovative and first-of-its-kind project aims to develop a cost-effective, carbon negative fertiliser that reduces fertiliser inputs and increases soil carbon storageRead moreRead less
A Data-Centric Mobile Edge Platform for Resilient Logistics & Supply Chain. This project aims to develop a secure mobile edge computing platform for resilient logistic and supply chain management. It consists of easy-used functions that help businesses realise low latency, high reliability, low cost, and high security in their logistics and supply chain system. To cope with the vast generated application data, we invent new data replication, placement, and deduplication techniques to optimise th ....A Data-Centric Mobile Edge Platform for Resilient Logistics & Supply Chain. This project aims to develop a secure mobile edge computing platform for resilient logistic and supply chain management. It consists of easy-used functions that help businesses realise low latency, high reliability, low cost, and high security in their logistics and supply chain system. To cope with the vast generated application data, we invent new data replication, placement, and deduplication techniques to optimise the mobile edge computing platform from the computation, storage, and network aspects. The invented mobile edge computing platform will enable more intelligent business applications for various industries, e.g., IT, manufacturing, and media, to appear, thus benefiting both the economy of Australia.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH230100010
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Smart Process Design and Control . ARC Research Hub for Smart Process Design and Control aims to develop and apply advanced computational technologies to model and optimise complex multiphase processes by integrating the novel multiscale and AI modelling approaches. The outcomes include theories, computer models and simulation techniques, advanced knowledge about process modelling and optimisation, innovative technologies and processes for low carbon operations, and tens of ....ARC Research Hub for Smart Process Design and Control . ARC Research Hub for Smart Process Design and Control aims to develop and apply advanced computational technologies to model and optimise complex multiphase processes by integrating the novel multiscale and AI modelling approaches. The outcomes include theories, computer models and simulation techniques, advanced knowledge about process modelling and optimisation, innovative technologies and processes for low carbon operations, and tens of postdoc and PhD students through academic, industrial and international collaboration. Their application will significantly improve energy/process efficiency and reduce CO2 emission. The Hub will generate a significant impact on the mineral and metallurgical industries which are important to Australia.Read moreRead less