Linking individual traits, the gut microbiome and parasite load in wildlife. This project aims to apply principles of community ecology to the gut microbiome of an urban exploiter – the common brushtail possum - to reveal how animal traits influence individual variation in the load of gut parasites that cause disease in both humans and wildlife. By combining assays defining the behavioural and physiological states of individuals with sophisticated analyses of their gut microbiome, our project wi ....Linking individual traits, the gut microbiome and parasite load in wildlife. This project aims to apply principles of community ecology to the gut microbiome of an urban exploiter – the common brushtail possum - to reveal how animal traits influence individual variation in the load of gut parasites that cause disease in both humans and wildlife. By combining assays defining the behavioural and physiological states of individuals with sophisticated analyses of their gut microbiome, our project will provide a new, yet crucial, perspective on how and why diseases spread. Our discoveries will help understand and manage the burden of infectious diseases from parasites in and beyond our cities and across the human-wildlife interface; essential for improving human and wildlife health in an increasingly urbanised Australia.Read moreRead less
Microbial community stability dynamics to environmental triggers. This project aims to advance our knowledge of the structural/functional dynamics of complex microbial communities by defining stability in response to environmental influences such as nutrient stress, pathogen invasion and antibiotics/chemicals. Using innovative microbial consortia modelling, to identify communities at risk of homeostatic disruption, we will develop and test pre-emptive microbial manipulation strategies for restor ....Microbial community stability dynamics to environmental triggers. This project aims to advance our knowledge of the structural/functional dynamics of complex microbial communities by defining stability in response to environmental influences such as nutrient stress, pathogen invasion and antibiotics/chemicals. Using innovative microbial consortia modelling, to identify communities at risk of homeostatic disruption, we will develop and test pre-emptive microbial manipulation strategies for restoring community stability. This project will yield significant global impact and economic/health benefit for humans and animals.Read moreRead less
Formation and stabilisation of coastal blue carbon. Blue carbon is organic carbon stored within coastal vegetated ecosystems. This project will examine the composition, formation and dynamics of blue carbon in a range of coastal ecosystems. Combining advanced analytical chemistry with environmental microbiology, we will discover how blue carbon is stabilised and destabilised, a critical factor in nature-based climate change mitigation strategies. Further, we will gain a quantitative understandin ....Formation and stabilisation of coastal blue carbon. Blue carbon is organic carbon stored within coastal vegetated ecosystems. This project will examine the composition, formation and dynamics of blue carbon in a range of coastal ecosystems. Combining advanced analytical chemistry with environmental microbiology, we will discover how blue carbon is stabilised and destabilised, a critical factor in nature-based climate change mitigation strategies. Further, we will gain a quantitative understanding of blue carbon contributions to carbon cycling, providing enhanced modeling and prediction of climate-cycle feedbacks in response to biotic and environmental change. This research will significantly benefit Australia’s effective management of coastal vegetated ecosystems for maximum carbon offsets.Read moreRead less
Biogeochemistry of ferruginous duricrusts. The project is focussed on the examination and application of microbial iron cycling in the formation of geologically stable, iron duricrusts in tropical regimes. The aim of the project is to develop a site-scale bioremediation strategy for iron ore mines by re-establishing canga, which are ‘ancient’ distinct ecosystems possessing unique plant species rarely found on Earth. This university-industry collaboration aims to produce economic benefits for the ....Biogeochemistry of ferruginous duricrusts. The project is focussed on the examination and application of microbial iron cycling in the formation of geologically stable, iron duricrusts in tropical regimes. The aim of the project is to develop a site-scale bioremediation strategy for iron ore mines by re-establishing canga, which are ‘ancient’ distinct ecosystems possessing unique plant species rarely found on Earth. This university-industry collaboration aims to produce economic benefits for the world’s iron mining industry through advanced training in mining-related research, and through the completion of the mining life cycle by site remediation, enhancing Australia’s position as a global leader in providing innovative solutions to today’s mining challenges.Read moreRead less
Molecular fossils, environmental genomics and the natural history of an Australian salt lake. Increasing salinity of lakes is a critical problem for sustainable water supply in Australia. To comprehend the consequences of human-induced salinization, it is crucial to understand salt lakes at their most fundamental level. This project develops pioneering technologies to elucidate the microbial ecology and geochemistry of salt lakes in unprecedented detail. It will open new pathways to unravel how ....Molecular fossils, environmental genomics and the natural history of an Australian salt lake. Increasing salinity of lakes is a critical problem for sustainable water supply in Australia. To comprehend the consequences of human-induced salinization, it is crucial to understand salt lakes at their most fundamental level. This project develops pioneering technologies to elucidate the microbial ecology and geochemistry of salt lakes in unprecedented detail. It will open new pathways to unravel how microbial ecosystems adapt to increasing salinization, and how they reacted to climate fluctuations in the past. Students will gain multidisciplinary skills in environmental genomics, proteomics and geochemistry, a unique combination that will become decisive for understanding and preserving ecosystems on our continent.Read moreRead less
Australia's ocean microbiome: how the diversity and functionality of microbes influence key oceanographic provinces. Every millilitre of seawater contains millions of microbes that maintain the health of our planet, but their identity and function in Australian waters is undefined. This project will identify the microbes inhabiting Australian marine systems, elucidate the services they provide, and predict how they will be affected by future environmental changes
The ecological dynamics of secreted bacteriocins and the evolution of multiple bacteriocin production in Escherichia coli. Bacteria produce compounds known as bacteriocins that are toxic to other microorganisms. The success of bacteria as bio-control agents and in probiotic formulations for the control microbial pathogens is, in part, due to bacteriocins. Bacteriocins may also have a role as replacements for traditional antibiotics and as natural food preservatives. The potential usefulness of b ....The ecological dynamics of secreted bacteriocins and the evolution of multiple bacteriocin production in Escherichia coli. Bacteria produce compounds known as bacteriocins that are toxic to other microorganisms. The success of bacteria as bio-control agents and in probiotic formulations for the control microbial pathogens is, in part, due to bacteriocins. Bacteriocins may also have a role as replacements for traditional antibiotics and as natural food preservatives. The potential usefulness of bacteriocins as the active agent in bio-control agents, as antibiotic replacements, as food preservatives, and as part of the repertoire of traits in probiotic formulations requires a sound understanding of the eco-evolutionary dynamics of bacteriocins. Understanding the ecology and evolution of bacteriocins is the goal of the proposed research.Read moreRead less
The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between ....The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between RRV strain and increased risk of RRV transmission and/or occurrence of more severe cases of human disease. It will help develop technologies that can lead towards the identification of viral markers, which could provide new avenues in the design of novel antiviral strategies.
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Incorporating new knowledge of phytoplankton diversity and nutrient utilisation into an ocean-climate model to improve forecasts of ocean function. Phytoplankton drives ocean biogeochemical cycles and regulate Earth’s climate yet are poorly represented in ocean-climate models. This project will use advanced cell sorting and analysis techniques and innovative selection experiments to gain a deeper understanding of phytoplankton diversity and nutrient utilisation under projected climate change. Th ....Incorporating new knowledge of phytoplankton diversity and nutrient utilisation into an ocean-climate model to improve forecasts of ocean function. Phytoplankton drives ocean biogeochemical cycles and regulate Earth’s climate yet are poorly represented in ocean-climate models. This project will use advanced cell sorting and analysis techniques and innovative selection experiments to gain a deeper understanding of phytoplankton diversity and nutrient utilisation under projected climate change. This new knowledge will be used to improve the biological structure of an existing coupled ocean-climate model and reduce key uncertainties in forecasts of ocean function. This research will provide managers and industry with more accurate insight into the effects of ongoing climate change on the delivery of ecosystem services in eastern Australian waters.Read moreRead less
Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme fun ....Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme functions in the koala’s gut, the investigators aims to reveal the role of microbes in detoxification of plant toxins and degradation of recalcitrant fibre fractions. The outcomes aim to facilitate the use of faecal transplants to improve digestive function for translocated and rehabilitated koalas, enhancing options for koala management and conservation.Read moreRead less