New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, ....New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, DNA damage and DNA repair using novel DNA biosensors. the novelty of the biosensor technology will be to use the modulation of charge transfer through DNA as a method for determining the structural changes that occur in DNA due to these events occurring.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989068
Funder
Australian Research Council
Funding Amount
$637,120.00
Summary
Equipment for Metastable Induced Electron Spectroscopy: surface analysis with excellent surface sensitivity. One of the major research strengths of Australia is surface science as it is important for both fundamental and industry related research. In many cases it is crucial to investigate the outermost layer of a material or mineral. Metastable Induced Electron Spectroscopy is an ideal technique as it is sensitive exclusively to the outermost layer of a broad range of samples. The information g ....Equipment for Metastable Induced Electron Spectroscopy: surface analysis with excellent surface sensitivity. One of the major research strengths of Australia is surface science as it is important for both fundamental and industry related research. In many cases it is crucial to investigate the outermost layer of a material or mineral. Metastable Induced Electron Spectroscopy is an ideal technique as it is sensitive exclusively to the outermost layer of a broad range of samples. The information gained is not accessible by any other method. The proposed equipment will be the first of this type in Australia and will complement existing surface science facilities. The project will enhance Australia's position in surface science internationally and a large number of projects will benefit from access to the equipment.Read moreRead less