Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importan ....Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importance on the regulatory function of miRNAs. Such information is critical in the future development of targeted therapeutics.Read moreRead less
Understanding the robustness and plasticity of metabolite concentrations. This project aims to further the understanding of how organisms mitigate the effects of changing environment by altering metabolite concentrations, important for food quality, energetics, and health. Through this understanding, the project provides the potential to precisely tailor metabolic intervention strategies, highly beneficial for applied sciences. The expected outcome of the project is a suite of computational appr ....Understanding the robustness and plasticity of metabolite concentrations. This project aims to further the understanding of how organisms mitigate the effects of changing environment by altering metabolite concentrations, important for food quality, energetics, and health. Through this understanding, the project provides the potential to precisely tailor metabolic intervention strategies, highly beneficial for applied sciences. The expected outcome of the project is a suite of computational approaches that allow for integration of large-scale data with networks to predict metabolite concentration ranges. This will provide significant benefit with the aim of maintaining outstanding research in Australia, and has clear potential for improved human health and enhanced food quality via metabolic reprogramming.Read moreRead less