Inferring Global Regulatory Architecture Of Human Gene Expression In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$47,427.00
Summary
Our genome encodes ~25,000 genes that shape out an individual from head to toe. Malfunction of a particular gene could cause fatal health problem or disease. Nonetheless, the mis-regulation of functioning genes can also result in serious diseases. In this study, we are going to use large-scale gene regulation information and advanced computing techniques to clarify the regulation network of human genome on a global level. Hence, helping us to understand more about diseases of gene transcription.
Computerised Surveillance Of Invasive Fungal Infections In Hospitals Using Existing Hospital Information Systems
Funder
National Health and Medical Research Council
Funding Amount
$123,453.00
Summary
Patients undergoing organ transplants or chemotherapy for cancer are susceptible to infections caused by fungi. Hospital outbreaks of fungal infections related to construction have occurred. Monitoring of these infections is required due to their considerable heath and economic costs. We aim to build a computerised system allowing for the real-time identification of fungal infections, leading to improved outcomes for patients, early recognition of hospital outbreaks and cost-savings.
Genomic Adaptation Of Pseudomonas Aeruginosa In The Cystic Fibrosis Airway
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Pseudomonas aeruginosa (Pa) is an important respiratory pathogen in Cystic Fibrosis (CF) which causes substantial morbidity and mortality. Its genetic versatility enables it to thrive in a wide diversity of environment. This study aims to assess the genomic adaptation of the common Pa strains among the Australian CF patients during chronic infection and during intravenous antibiotics therapy. The study results can lead to development of novel treatment options for Pa infection in CF.
Next Generation Sequencing Of Hepatitis C Virus To Detect Drug Resistance Mutations
Funder
National Health and Medical Research Council
Funding Amount
$39,497.00
Summary
Hepatitis C is the leading cause of liver cancer and liver failure requiring transplantation in Australia. New antiviral drugs set to revolutionise hepatitis C treatment by substantially improving cure rates could be challenged by the development of resistance mutations, which would make these drugs less effective. We aim to develop a practical test to be used routinely to guide clinicians in choosing appropriate anti-viral drugs for their patients.