Special Research Initiatives - Grant ID: SR0567493
Funder
Australian Research Council
Funding Amount
$99,146.00
Summary
E-Services for Comparative Studies in Molecular Biology. The central challenge of post-genomic biology is to exploit the range of sequence and microarray data to yield greater understanding of biological processes. Large comparative studies are hamstrung by the inaccessibility of specialist comparative tools and the problem of managing large-scale disparate data. This project will provide portal and web services facilities to remove these obstacles, relying on robust and scalable business techno ....E-Services for Comparative Studies in Molecular Biology. The central challenge of post-genomic biology is to exploit the range of sequence and microarray data to yield greater understanding of biological processes. Large comparative studies are hamstrung by the inaccessibility of specialist comparative tools and the problem of managing large-scale disparate data. This project will provide portal and web services facilities to remove these obstacles, relying on robust and scalable business technologies to be made freely available. Our work will be driven by specific applications in bacterial genomics and cancer research, and will support research into prostate cancer and the pathogens Chlamydia and Bacillus anthracis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100150
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Beyond Proteomics: structure and function of protein modifications. The world's leading cancer therapeutics have come from the protein phosphorylation field, and glycomics has led to drugs that combat the flu and that stimulate red blood cell production in cancer patients. Thus there is a bright future for discovery of new medicines based on new knowledge in this area. Protein modifications are key to the understanding of disease mechanisms and for searching for new disease markers and new the ....Beyond Proteomics: structure and function of protein modifications. The world's leading cancer therapeutics have come from the protein phosphorylation field, and glycomics has led to drugs that combat the flu and that stimulate red blood cell production in cancer patients. Thus there is a bright future for discovery of new medicines based on new knowledge in this area. Protein modifications are key to the understanding of disease mechanisms and for searching for new disease markers and new therapeutics. In the hands of local experts the instruments will enable identification of these modifications and provide improved understanding of biology, increase the national competitiveness of Australia's scientists, and provide advanced technology training to the next generation of scientists.Read moreRead less
Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary geneti ....Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary genetics and dynamics of virus populations in order to understand how to control epidemics, develop vaccines and design drugs. The research program is designed to provide new computational modelling tools for this purpose, which may have wider applications as well.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100226
Funder
Australian Research Council
Funding Amount
$424,000.00
Summary
Advanced molecular discovery and characterisation facility. Natural product drug discovery in Australia requires access to high throughput functional assays to guide the separation and of novel bioactives with therapeutic potential. By establishing the advanced molecular discovery and characterisation facility in an academic environment across two institutions, research programs in early drug lead discovery and characterisation will be accelerated. It will provide unique capabilities not curren ....Advanced molecular discovery and characterisation facility. Natural product drug discovery in Australia requires access to high throughput functional assays to guide the separation and of novel bioactives with therapeutic potential. By establishing the advanced molecular discovery and characterisation facility in an academic environment across two institutions, research programs in early drug lead discovery and characterisation will be accelerated. It will provide unique capabilities not currently available in Australia, and help Australian researchers remain internationally competitive in breakthrough science and frontier technologies. The research enabled by this facility will lead to development of new drug candidates by the emerging Australian biotechnology industry.Read moreRead less